Clinical trials
Crohn's Disease, Active clinical trials
Below are recruiting crohn's disease, active clinical trials, each written for real people, not researchers. We’re tracking 198 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07310095RecruitingPhase 4
Study of ustekinumab for Crohn's disease with loss of response
This study tests a new treatment for people with Crohn's disease who have lost response to ustekinumab (Stelara). It aims to see if a different dosing or additional treatment can help regain control of symptoms.
GuangzhouAges 18 years+ - NCT06925594RecruitingPhase 3
Cell injection for Crohn's-related anal fistulas
This trial tests a new cell injection (TH-SC01) to treat anal fistulas caused by Crohn's disease. It aims to see if the injection can heal fistulas and lower infection risk.
Nanjing, JiangsuAges 18–70 - NCT06958159Recruiting
Comparing treatments for short Crohn's strictures
This trial tests a new approach that combines two procedures (stricturotomy and balloon dilation) against stricturotomy alone to treat short narrowed areas (strictures) caused by Crohn's disease. The goal is to see which method works better for keeping the bowel open longer.
Hyderabad, TelanganaAges 18–65 - NCT06203782Recruiting
Comparing two treatments for Crohn's disease strictures
This trial compares two ways to treat narrowed areas (strictures) in the gut caused by Crohn's disease: endoscopic strictureplasty versus balloon dilation. It aims to see which method works better for people whose strictures are manageable with a scope.
Hangzhou, HangzhouAges 18–75 - NCT06647615Recruiting
Virtual reality for stomach pain in Crohn's disease
This study tests if using a virtual reality (VR) program can help reduce stomach pain in people with Crohn's disease that is not currently active. You will try the VR experience and report how your pain changes.
Jacksonville, FloridaAges 18–70 - NCT06512597Recruiting
Behavioral therapy for active Crohn's disease
This study tests whether a behavioral therapy program can help people with active Crohn's disease feel better when they start a new biologic medication. You'll get extra support to manage stress and symptoms while you and your doctor adjust your treatment.
New York, New YorkAges 18–65 - NCT06227910RecruitingPhase 3
Study of vedolizumab with or without upadacitinib for Crohn's disease
This trial tests combining two medicines, vedolizumab and upadacitinib, to see if they work better together than vedolizumab alone for people with moderate to severe Crohn's disease that hasn't responded well to other treatments.
La Jolla, CaliforniaAges 18–65 - NCT06006039Recruiting
Study on immune cells and Crohn's disease recurrence after surgery
This study looks at how certain immune cells relate to Crohn's disease coming back after bowel surgery. The goal is to better understand why some patients have a recurrence, which could help improve future treatments.
Toronto, OntarioAges 18 years+ - NCT05837897RecruitingPhase 3
Vedolizumab for adults with moderate-to-severe Crohn’s
This Phase 3 study tests whether vedolizumab can better control moderate-to-severe Crohn’s disease in adults whose symptoms haven’t improved enough with other treatments. You’d need to meet specific symptom scores, recent colonoscopy findings, and safety checks (including infections and vaccination status).
Hefei, AnhuiAges 18–80 - NCT06045754RecruitingPhase 4
Study of vedolizumab with other drugs for Crohn's disease
This trial tests whether combining vedolizumab with adalimumab or ustekinumab helps people with moderate to severe Crohn's disease who haven't responded to other treatments. It aims to find better ways to manage symptoms and improve quality of life.
Dothan, AlabamaAges 18–70 - NCT05906576RecruitingPhase 4
Infliximab monitoring study for children with Crohn’s disease
This study keeps track of how infliximab works and how safe it is in Chinese children with moderate-to-severe active Crohn’s disease. You may be eligible if this is the first time your child is starting infliximab and you agree to provide study information.
BeijingAges 6–17 - NCT05849012Recruiting
Low-sulfur diet study for Crohn’s symptoms when disease is quiet
This pilot study tests whether a low-sulfur diet can improve ongoing belly pain and/or diarrhea symptoms in people with Crohn’s disease that looks “quiet” on tests. If you still feel symptoms even though inflammation is not active, this could help by targeting diet-related triggers.
Ann Arbor, MichiganAges 18 years+ - NCT05509777RecruitingPhase 3
Mirikizumab for children with active Crohn’s disease
This study tests mirikizumab to reduce inflammation and symptoms in children with Crohn’s disease that is currently active. It may help if your Crohn’s has not improved enough (or stopped working) with at least one other Crohn’s medicine.
Los Angeles, CaliforniaAges 2–17 - NCT00692939RecruitingPhase 1/Phase 2
Stem cell transplant for people with Crohn’s who need new options
This trial studies whether an “autologous” stem cell transplant (using your own cells) can improve Crohn’s disease that has not responded to standard treatments. It may help people who have ongoing, hard-to-control Crohn’s even after medicines and/or who have complications that make surgery risky.
Pittsburgh, PennsylvaniaAges 10–60 - NCT07191106Recruiting
Remote exercise program for inflammatory bowel disease
This study tests whether a remote exercise program, done at home using an app, can improve quality of life for people with inflammatory bowel disease (IBD). It may help if you are motivated to start a gentle physical activity routine and have internet access.
MontfermeilAges 18 years+ - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT07683325RecruitingPhase 2
Study of ontunisertib for fibrostenosing Crohn's disease
This trial tests an investigational drug called ontunisertib versus a placebo in people with Crohn's disease that has caused narrowing (strictures) in the small intestine. It aims to see if the drug can help without needing surgery or other procedures.
Bradenton, FloridaAges 18 years+ - NCT07556718RecruitingPhase 2
Amitriptyline for IBS-like Symptoms in Stable Crohn's Disease
This study tests whether a medication called amitriptyline can help reduce belly pain and bowel problems in people whose Crohn's disease is well-controlled. Amitriptyline is an older antidepressant that may help with pain and bowel symptoms even when inflammation is quiet.
Ann Arbor, MichiganAges 18–65 - NCT07522528Recruiting
Biologics and Nutrition Treatment for Active Crohn's in Young People
This study tests whether combining biologic medicines (TNF-alpha inhibitors like infliximab or adalimumab) with a special nutrition plan helps young people with active Crohn's disease feel better. The nutrition plan may include drinking special formula drinks instead of regular food (or alongside some regular food).
AberdeenAges 6–18 - NCT07246460Recruiting
Ultrasound and protein tests to see if guselkumab works for Crohn's
This study tests whether guselkumab (a targeted drug) can effectively treat Crohn's disease in the ileum (last part of the small intestine). You will have ultrasound scans and blood tests to measure your response, which may help find the right dose and monitor for bowel healing.
Calgary, AlbertaAges Up to 80 years - NCT04779320RecruitingPhase 3
Vedolizumab for teens with moderate to severe Crohn's
This trial tests vedolizumab to treat children and teens with moderate to severe Crohn’s disease when standard treatments haven’t worked or caused side effects. It may help reduce gut inflammation and symptoms and help some patients stay healthier over time.
Phoenix, ArizonaAges 2–17 - NCT07483073RecruitingPhase 2
Study of new drugs for moderate to severe ulcerative colitis or Crohn's disease
This trial is testing multiple new drugs for people with moderate to severe ulcerative colitis or Crohn's disease who have not had success with at least one standard treatment. The goal is to find a better option that can help control symptoms and inflammation.
Scottsdale, ArizonaAges 18–80 - NCT07111715Recruiting
AI vs. standard reading for suspected Crohn disease
This study tests whether an artificial intelligence (AI) system can help doctors find signs of Crohn's disease better than standard reading of capsule endoscopy images. It is for people who have symptoms that might be Crohn's but whose colonoscopy didn't clearly show the problem.
Brescia, BresciaAges 18–75 - NCT04740541Recruiting
Diet study for adult men with Crohn’s disease
This study looks at how a specific amino-acid (threonine) diet affects adults with Crohn’s disease and signs of intestinal inflammation. It may help researchers understand what dietary protein needs could support more stable disease.
Toronto, OntarioAges 18–49
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Common questions
- Are there clinical trials for crohn's disease, active?
- Yes. Clin2 currently lists 198 recruiting crohn's disease, active studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a crohn's disease, active trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a crohn's disease, active trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.