Clinical trials
Cryotherapy clinical trials
Below are recruiting cryotherapy clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06939374Recruiting
Freezing heart arteries to stabilize high-risk plaques
This study tests a special cooling balloon to freeze and stabilize dangerous plaques in heart arteries that are not the main cause of your current symptoms. It aims to prevent future heart attacks.
AalstAges 18 years+ - NCT07630337Recruiting
Cryotherapy to reduce pain medication after knee replacement
This study tests whether applying cold therapy (cryotherapy) after knee replacement surgery helps patients need fewer opioid pain medications than standard care alone. If cryotherapy works, it could help you manage pain more safely after surgery.
Buenos Aires, Buenos AiresAges 18 years+ - NCT06400849Recruiting
Cooling and compression to prevent nerve damage from chemo
This trial tests whether adding a cooling and compression treatment to your hands and feet during chemotherapy can help prevent nerve damage (neuropathy) caused by the drug paclitaxel. It may be a good option for people with breast cancer who are about to start this type of chemotherapy and want to reduce side effects.
NiceAges 18–99 - NCT05738187Recruiting
Cryotherapy for repeat head and neck cancer after prior radiation
This pilot study tests whether cooling treatment on the tumor area (cryotherapy) can control a repeat head/neck cancer that can’t be removed and has already been treated with radiation. It also checks safety, especially in areas that have received radiation before.
StrasbourgAges 18 years+ - NCT02381990Recruiting
MRI- and ultrasound-guided freezing treatment for low-risk prostate cancer
This trial tests using MRI and ultrasound together to guide freezing (cryoablation) treatment for prostate cancer. It may help target the tumor more precisely while avoiding areas that could cause side effects.
Miami Lakes, FloridaAges 55 years+ - NCT05199376Recruiting
Cryotherapy treatment for painful, hard-to-remove NF1 tumors
This trial tests whether freezing treatment done through the skin (cryotherapy) can reduce pain and discomfort from certain non-cancer NF1 tumors that can’t be safely removed. You may be able to join if you’re an adult with NF1, a painful or bothersome benign lesion, and can safely undergo procedures like MRI.
LyonAges 18 years+ - NCT07780955Recruiting
Cold therapy for nerve damage from paclitaxel chemotherapy
This study tests whether wearing cold gloves and socks during paclitaxel chemotherapy can prevent or reduce nerve damage in the hands and feet, a common side effect. If you are getting weekly paclitaxel for breast cancer, this might help keep your hands and feet more comfortable.
Bolzano, BolzanoAges 18–90 - NCT07603960Recruiting
Cold therapy to ease endometriosis pelvic pain
This study tests whether exposing your whole body to very cold air (below freezing) can reduce chronic pelvic pain from endometriosis and improve your quality of life. Endometriosis is a condition where tissue similar to the uterine lining grows outside the uterus, often causing pain.
Edinburgh, ScotlandAges 16 years+ - NCT07531056RecruitingEarly Phase 1
5-Fluorouracil injections with or without freezing for keloid scars
This trial tests two ways to treat keloids (thick, raised scars that grow beyond the original wound): injecting a medication called 5-fluorouracil alone, or combining it with cryotherapy (freezing). The goal is to see which approach works better for reducing pain, itching, and visible scarring.
Chak Four Hundred Fifty-fourAges 18–50 - NCT07517367RecruitingPhase 4
Cooling before numbing for tooth nerve pain
This study tests whether applying cold to your gum before a numbing injection helps the anesthetic work better for a severely painful lower front tooth. Researchers want to see if this simple cooling step reduces pain during the procedure.
Samsun, AtakumAges 18–60 - NCT07366736Recruiting
Cold and compression after knee replacement – a study
This study tests if a cooling and compression device applied to the knee after replacement surgery helps with pain and recovery. It compares the device to standard care in people having their first knee replacement.
ÉchirollesAges 18 years+ - NCT07336368RecruitingPhase 3
Cold therapy plus steroid injections for raised scars
This study tests whether adding a cold therapy treatment (cryotherapy) to standard steroid injections can improve keloids and hypertrophic scars. If you are already getting steroid shots for your scar, you may be able to join and get both treatments on different parts of one scar.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06772662Recruiting
Ice machine tubing placement study for knee surgery
This study looks at how teens prefer the tubing placement on their ice machine after knee surgery. It may help improve comfort during recovery.
Orange, CaliforniaAges 10–18 - NCT06718192RecruitingPhase 1/Phase 2
Bleomycin vs. freezing for plantar warts
This study compares two treatments for plantar warts: a medicine called bleomycin and freezing (cryotherapy). It aims to see which works better and is safe. If you have a plantar wart, you may be able to join and get one of these treatments.
Yiwu, ZhejiangAges 18–65 - NCT07169799Recruiting
Freezing spray for GAVE stomach bleeding
This study tests a freezing spray (Tru-Freeze) to treat GAVE, a condition that causes stomach bleeding. It may help people who need blood transfusions because of GAVE and have had few or no prior endoscopic treatments.
Jacksonville, FloridaAges 18 years+ - NCT06955702Recruiting
Cryotherapy to Prevent Eyelash Loss from Chemo
This trial tests if cooling the eyelids during chemotherapy can prevent eyelash loss in women with newly diagnosed breast cancer. It is for those who have not yet started treatment.
Santander, CantabriaAges 18 years+ - NCT05091255Recruiting
Cold therapy for desmoid tumors in adults
This trial tests whether “cold therapy” (cryotherapy) can shrink or control desmoid tumors. It may help adults whose tumors are located in certain body areas where cryotherapy is considered safe.
Bologna, BOAges 18 years+ - NCT06569615Recruiting
Comparing shock wave, laser, and cold therapy for sacroiliitis pain
This trial compares three different treatments (shock wave therapy, laser therapy, and cold therapy) for people with sacroiliitis, a condition that causes pain in the lower back, buttocks, or hips. The goal is to see which treatment works best for reducing pain and improving movement.
Najran, Najran RegionAges 20–50 - NCT06461442Enrolling by invitationPhase 4
Freezing vs. cream for sun-damaged spots
This study compares two ways to treat sun-damaged spots called actinic keratoses: freezing them (cryotherapy) or applying a chemotherapy cream (5-fluorouracil). The goal is to see which works better and is safer for people with many spots on their head, neck, arms, or legs.
Sacramento, CaliforniaAges 18 years+ - NCT05665244Recruiting
Cryotherapy for long-lasting cough from nerve signals
This trial tests a cold-treatment procedure (cryotherapy) to treat a stubborn cough caused by nerve signaling (not infections or common allergy/acid problems). It may help people whose cough has lasted at least 8 weeks and who have already tried to rule out other causes.
Dallas, TexasAges 18 years+ - NCT05341141Recruiting
Cold therapy plus compression to prevent nerve damage from chemo
This trial tests whether using cold therapy (cryotherapy) together with compression can lower the chance of numbness, tingling, or pain in the hands and feet caused by chemotherapy. It may help people planning chemotherapy for breast cancer stay more comfortable and function better.
Beijing, Beijing MunicipalityAges 20–70 - NCT05928429Recruiting
Cold treatment to prevent nerve pain from weekly paclitaxel
This trial tests whether cryotherapy (cooling the hands/feet during chemo) can prevent or lessen nerve pain caused by paclitaxel in people with early breast cancer. It may help you stay more comfortable and function better during treatment.
CopenhagenAges 18 years+ - NCT01788410Recruiting
MRI-guided freezing treatment for neck, head, and spine pain
This trial studies an MRI-guided procedure that “freezes” targeted nerves or joints to reduce pain in the head, neck, or spine. It may help if your pain comes from a joint problem or a compressed/damaged nerve and you can safely have MRI scans before and after the treatment.
Boston, MassachusettsAges 18 years+ - NCT07771816Enrolling by invitation
Mouth rinse and cold therapy for lower molar pain
This study tests whether using different strengths of a disinfectant rinse inside the tooth, sometimes combined with cold therapy, can reduce pain after a type of root canal treatment for lower molars. It aims to find the most comfortable and effective approach for managing post-procedure pain.
Cairo, Cairo GovernorateAges 15–40
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Common questions
- Are there clinical trials for cryotherapy?
- Yes. Clin2 currently lists 46 recruiting cryotherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cryotherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cryotherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.