Clinical trials
Cryotherapy clinical trials
Below are recruiting cryotherapy clinical trials, each written for real people, not researchers. We’re tracking 46 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07764666Enrolling by invitation
Cooling rinse for molar pain after root canal treatment
This study tests whether using a chilled saline rinse during a root canal treatment can reduce pain after the procedure. It compares two standard rinses, with and without cooling, to see which is more comfortable.
Cairo, Cairo GovernorateAges 15–40 - NCT06645262Recruiting
Ankle sprain rehab study
This study looks at therapies for a first-time mild ankle sprain (Grade I). It may help you recover faster and avoid future problems.
MostarAges 4 months+ - NCT06711081Recruiting
Laser and cold therapy for painful back tooth
This study tests whether using a low-level laser and cold therapy together helps heal a back tooth that has deep decay and is causing severe pain. The goal is to save the tooth and avoid a root canal.
TantaAges 15–60 - NCT07528482Recruiting
Reflexology and cold therapy for chest tube removal pain
This study tests whether foot massage (reflexology) and cold application can reduce pain when chest tubes are removed after heart bypass surgery. Researchers want to see if these complementary techniques help manage discomfort during this procedure.
AnkaraAges 18 years+ - NCT07431632Recruiting
Nerve freezing vs. epidural for pain after pectus excavatum repair
This study compares two ways to manage pain after pectus excavatum surgery: freezing the nerves during surgery (cryoanalgesia) versus an epidural block. The goal is to see which method provides better pain relief with fewer side effects.
São Paulo, São PauloAges 13 years+ - NCT07236398Enrolling by invitation
Modified left atrial maze procedure for atrial fibrillation
This trial tests a modified maze procedure to treat atrial fibrillation during heart surgery. It may help patients with AFib who are already scheduled for cardiac surgery.
Toulouse, French (France)Ages 18 years+ - NCT07222657RecruitingPhase 2
Freezing spray before chemo for esophageal cancer
This trial tests a freezing spray (cryotherapy) to shrink esophageal tumors before standard chemotherapy. It may help reduce tumor size and improve treatment outcomes.
Weston, FloridaAges 18 years+ - NCT07184957Recruiting
Cryotherapy for localized prostate cancer: a data study
This study tracks outcomes for men who choose cryotherapy (freezing cancer cells) to treat prostate cancer that hasn't spread. It helps doctors understand how well this treatment works.
New York, New YorkAges 40–85 - NCT07081620Recruiting
Freezing rib nerves before chest-wall repair
This study tests how the timing of a nerve-freezing procedure (cryoneurolysis) in the ribs affects recovery from pectus excavatum surgery. It may help reduce pain after the operation.
Bergamo, BGAges 12–40 - NCT06861387Recruiting
Cryo nerve block for lung surgery pain
This trial tests a freezing technique to numb nerves around the lungs during minimally invasive lung surgery. It may help reduce pain after surgery, so you need less pain medication.
Nieuwegein, UtrechtAges 18 years+ - NCT06761170RecruitingPhase 2
Spray Freezing for Non-Cancerous Airway Narrowing
This trial is testing a treatment called spray cryotherapy, which uses extreme cold to open up a narrowed airway. It may help people with non-cancerous (benign) narrowing of the windpipe or voice box area that is causing symptoms like trouble breathing.
Boston, MassachusettsAges Any age - NCT06456268Recruiting
VibraCool to reduce pain and opioid use after ACL surgery
This trial tests a device called VibraCool to see if it can reduce pain and the need for opioid painkillers after ACL reconstruction surgery.
New York, New YorkAges Any age - NCT06356831Recruiting
Registry for surgery or freezing of abdominal wall endometriosis
This study tracks women who have surgery or a freezing treatment for endometriosis in the abdominal wall. It aims to learn which treatment works best for pain, bleeding, or quality-of-life issues.
BordeauAges 18 years+ - NCT06178354Recruiting
Freezing or ultrasound for early prostate cancer
This trial is testing whether freezing (cryotherapy) or using high-frequency ultrasound (HIFU) to destroy only the cancer spots in the prostate is safe and effective for men with early-stage prostate cancer. It's a less invasive option that targets just the tumor, not the whole prostate.
Sacramento, CaliforniaAges 18 years+ - NCT06139458Recruiting
Cooling therapy to prevent nerve damage from chemo
This trial tests if cooling sleeves and gloves during chemotherapy can help prevent nerve damage (peripheral neuropathy) in people with gynecologic cancers. If you are receiving a common chemo drug called paclitaxel, this approach might reduce side effects like numbness or pain in your hands and feet.
Hartford, ConnecticutAges 18 years+ - NCT06085209RecruitingPhase 1
Cold spray treatment for non-cancerous airway narrowing
This trial tests a freezing spray (cryospray) to treat narrowing of the windpipe (trachea) that is not caused by cancer. It may be an option if you need a procedure to open your airway.
Richmond, VirginiaAges 18 years+ - NCT05922657Recruiting
Registry study for Cerene cryotherapy in everyday use
This registry collects real-world information from people who are planning to use the Cerene cryotherapy device. You may benefit by helping researchers understand how it works in routine care and by completing periodic surveys for up to 12 months.
West Orange, New JerseyAges 25 years+ - NCT04681417RecruitingPhase 2/Phase 3
Eye-sparing treatment options for children with retinoblastoma
This trial studies whether newer “save-the-eye” treatment plans can control retinoblastoma (eye cancer) while keeping vision as good as possible. It compares different conservative treatment strategies depending on how the tumor looks and where it is.
Saint-Denis, La RéunionAges 6 months–6 years - NCT05454488RecruitingPhase 2
Study focal freezing for intermediate-risk prostate cancer
This trial tests whether freezing only the cancer area in the prostate (focal cryotherapy) can control intermediate-risk prostate cancer. It aims to limit treatment to one tumor focus while closely checking results with targeted and follow-up testing.
Houston, TexasAges 18 years+ - NCT03492424Recruiting
Focal prostate cancer treatment study
This study looks at outcomes after “focal therapy,” a type of treatment that targets only part of the prostate, for people with newly diagnosed or returning prostate cancer. It may help researchers understand how well this targeted approach works and for whom.
New York, New YorkAges 18 years+ - NCT05095909Recruiting
Frozen compression at intervals vs regular icing after shoulder surgery
This trial tests whether using a special device that gives cold in pulses (intermittent cryo-compression) helps the shoulder feel better after arthroscopic rotator cuff repair compared with traditional icing. It may help with pain and recovery during the early healing period after surgery.
Plymouth, MinnesotaAges 18–70 - NCT04339218RecruitingPhase 3
Cryoablation plus pembrolizumab and chemotherapy for lung cancer spread
This trial studies whether freezing a small number of lung cancer spots (cryoablation) alongside standard immunotherapy (pembrolizumab) and chemotherapy can improve outcomes in people with metastatic lung adenocarcinoma. It’s meant for people who have measurable tumors that can be safely targeted with the freezing treatment.
Bordeaux, GirondeAges 18 years+
Hear when a new Cryotherapy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for cryotherapy?
- Yes. Clin2 currently lists 46 recruiting cryotherapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cryotherapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cryotherapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.