Clinical trials
Cystic Fibrosis clinical trials
Below are recruiting cystic fibrosis clinical trials, each written for real people, not researchers. We’re tracking 154 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06163482Recruiting
Meal Hormone Study in Cystic Fibrosis
This study looks at how the body processes a mixed meal in people with cystic fibrosis who are on CFTR modulator therapy. It may help researchers understand how these medications change hormone and blood sugar responses.
Cincinnati, OhioAges 18–45 - NCT06950892Recruiting
Remote sputum collection study for cystic fibrosis
This study tests if people with cystic fibrosis can collect sputum samples at home and mail them in, instead of coming to the clinic. It aims to make participation easier for patients.
Denver, ColoradoAges 18 years+ - NCT06560463Recruiting
CGM and glucose test for cystic fibrosis related diabetes
This study tests if a continuous glucose monitor (CGM) along with a standard glucose drink test can better detect diabetes in people with cystic fibrosis. It is for adults who do not yet have diabetes and are generally healthy.
Milwaukee, WisconsinAges 18 years+ - NCT07729787Recruiting
Autogenic drainage vs. chest percussion for kids with CF
This trial compares two breathing techniques to help clear mucus from the lungs of children with cystic fibrosis. It aims to see if one method (autogenic drainage) works better than another (mechanical percussion with a vest).
Multan Khurd, Punjab ProvinceAges 6–12 - NCT03670472Recruiting
Gene therapy for cystic fibrosis with specific CFTR mutations
This study looks at correcting “stop” mistakes (nonsense mutations) in the CFTR gene, which can cause cystic fibrosis. If your CFTR test shows the exact type of mutation the study needs, you may be able to take part.
AmiensAges 8 years+ - NCT03839992Recruiting
Checks for hidden small airways blockage in cystic fibrosis
This trial looks for early, “hidden” breathing test abnormalities in people with cystic fibrosis who have normal routine lung test results. It may help researchers find blockage in smaller airways before it shows up on standard tests.
Lakewood, CaliforniaAges 5–40 - NCT03921060RecruitingPhase 4
Check osteoporosis markers in people with cystic fibrosis
This study looks for signs (markers) of bone thinning—called osteoporosis—in people with cystic fibrosis. Your participation may help researchers understand how osteoporosis develops in CF and whether a bone-strengthening medicine like denosumab could help, since some participants may need that medication.
Dallas, TexasAges 18–64 - NCT04732910Recruiting
Study of CFTR-modulator effects using body samples
This study looks at how well CFTR-modulator medicines are working in people with cystic fibrosis, by checking specific “biomarkers” (measurable signals) in samples. Your care team may use the results to better understand how these medicines help, especially for certain CFTR changes.
Berlin, State of BerlinAges 6 months+ - NCT05099939Recruiting
Monitoring sugar changes in adults with cystic fibrosis
This study uses continuous glucose monitoring (a sensor that checks blood sugar trends) to understand how sugar handling changes over time in people with cystic fibrosis. It may help doctors spot early “pre-diabetes” or abnormal sugar patterns sooner.
Montreal, QuebecAges 18 years+ - NCT05248230RecruitingPhase 2
Study drug for adults with cystic fibrosis lung disease
This Phase 2 trial tests 4D-710 to improve lung health in adults with cystic fibrosis who either cannot take CFTR modulator medicines or are not doing well enough on them. You may be eligible if you have moderate lung function and stable oxygen levels, and you meet other safety and health requirements.
Birmingham, AlabamaAges 18 years+ - NCT05279040Recruiting
Trikafta plus exercise program for adults with cystic fibrosis
This study tests how starting Trikafta affects exercise ability and breathing in adults with cystic fibrosis. You may be asked to do supervised breathing and exercise tests to see if Trikafta helps your lung function and stamina.
Vancouver, British ColumbiaAges 19 years+ - NCT05504837RecruitingPhase 1
Test KB407 inhaled treatment for adults with cystic fibrosis
This Phase 1 study tests the safety of KB407 and how it works in adults with cystic fibrosis (CF). It may help researchers understand whether this inhaled treatment could become a future option for CF.
Gainesville, FloridaAges 18 years+ - NCT05723445Recruiting
Low glycemic diet test for diabetes and body changes in CF
This trial studies whether a low glycemic load (a specific way of choosing carbohydrates) improves blood sugar control and body composition in adults with cystic fibrosis–related diabetes. It may help reduce blood sugar problems and support healthier weight and body measurements.
Boston, MassachusettsAges 18–70 - NCT05766774Recruiting
Diet study for adults with cystic fibrosis and high sugar intake
This trial studies whether changing eating habits—especially added sugar intake—affects health in adults with cystic fibrosis. It may help by testing a diet approach aimed at better outcomes related to metabolism and overall health.
Atlanta, GeorgiaAges 18 years+ - NCT05802264RecruitingPhase 1
Inhaled amphotericin B for healthy volunteers and cystic fibrosis
This early-phase study tests how different doses of an inhaled medicine (amphotericin B) work and are tolerated. It includes healthy adults and people with cystic fibrosis (CF) to see if the dose schedule is safe and potentially beneficial.
Canberra, Australian Capital TerritoryAges 16 years+ - NCT06191640Recruiting
Study of sinus disease in young children with cystic fibrosis
This study looks at sinus problems in young children with cystic fibrosis. One group of children starts a new medicine called a highly effective modulator (like Trikafta), and the other group does not take this medicine. The goal is to see how the medicine affects sinus health over time.
Aurora, ColoradoAges 2–8 - NCT06216704Recruiting
Bone health and marrow study in teens with cystic fibrosis
This study looks at how cystic fibrosis affects bone health and bone marrow in teenagers. It uses a special MRI scan to measure bone strength and marrow composition, which may help doctors better understand and prevent bone problems in people with CF.
Boston, MassachusettsAges 13–20 - NCT06284577Recruiting
Quality of life and gut health in children with cystic fibrosis
This study looks at how a drug called ETI (a combination of three medicines) affects the quality of life and gut health of children with cystic fibrosis. If you or your child has the right type of CF and is between 2 and 18 years old, this trial may help us understand how treatment improves daily life and digestion.
OsloAges 2–18 - NCT06364176RecruitingPhase 2
Adding losartan to improve Trikafta response in CF
This study tests whether adding the blood pressure medication losartan can help the standard CF drug Trikafta work better by reducing inflammation. It's for people with CF who still have high sweat chloride levels despite taking Trikafta.
Kansas City, KansasAges 12 years+ - NCT06370962Recruiting
Sleep study for children with cystic fibrosis on Kaftrio-Kalydeco
This study looks at sleep and daily activity rhythms in children with cystic fibrosis who are taking a medication called Kaftrio-Kalydeco. It aims to understand if the medication affects sleep patterns and how to improve them.
BronAges 2–17 - NCT06429176RecruitingPhase 2
SPL84 for cystic fibrosis with 3849+10kb mutation
This trial tests a new drug called SPL84 for people with cystic fibrosis who have a specific gene mutation (3849+10kb C->T). It aims to see if the drug is safe and can improve lung function. The study has two paths: one for people not taking certain CF drugs, and one for those who are already on Trikafta or Alyftrek.
Los Angeles, CaliforniaAges 18 years+ - NCT06507956Recruiting
Physical activity and sitting habits in adults with cystic fibrosis
This study looks at how physically active and sedentary adults with cystic fibrosis are. It uses a device to measure your daily movement and asks you to fill out a few questionnaires. The goal is to better understand your activity patterns and find ways to help you stay healthy.
Pierre-BéniteAges 18–65 - NCT05548283RecruitingPhase 4
Standard IV antibiotic timing for cystic fibrosis lung flare-ups
This study standardizes how IV aminoglycoside antibiotics are given during a 14-day treatment for cystic fibrosis (CF) lung flare-ups. It may help make treatment more consistent and easier to manage for people who need IV antibiotics.
Birmingham, AlabamaAges 6 years+ - NCT06616857Recruiting
Smartphone app to boost activity in teens with CF
This study tests a personalized smartphone app to help teens and young adults with cystic fibrosis be more active. The app provides tailored tips and support to encourage daily physical activity.
Jacksonville, FloridaAges 13–25
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Cystic Fibrosis trials by city
Studies with a site in or near these metro areas.
Cystic Fibrosis trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cystic fibrosis?
- Yes. Clin2 currently lists 154 recruiting cystic fibrosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cystic fibrosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cystic fibrosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.