Clinical trials
Cystic Fibrosis clinical trials
Below are recruiting cystic fibrosis clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06429176RecruitingPhase 2
SPL84 for cystic fibrosis with 3849+10kb mutation
This trial tests a new drug called SPL84 for people with cystic fibrosis who have a specific gene mutation (3849+10kb C->T). It aims to see if the drug is safe and can improve lung function. The study has two paths: one for people not taking certain CF drugs, and one for those who are already on Trikafta or Alyftrek.
Los Angeles, CaliforniaAges 18 years+ - NCT06216704Recruiting
Bone health and marrow study in teens with cystic fibrosis
This study looks at how cystic fibrosis affects bone health and bone marrow in teenagers. It uses a special MRI scan to measure bone strength and marrow composition, which may help doctors better understand and prevent bone problems in people with CF.
Boston, MassachusettsAges 13–20 - NCT06191640Recruiting
Study of sinus disease in young children with cystic fibrosis
This study looks at sinus problems in young children with cystic fibrosis. One group of children starts a new medicine called a highly effective modulator (like Trikafta), and the other group does not take this medicine. The goal is to see how the medicine affects sinus health over time.
Aurora, ColoradoAges 2–8 - NCT06163482Recruiting
Meal Hormone Study in Cystic Fibrosis
This study looks at how the body processes a mixed meal in people with cystic fibrosis who are on CFTR modulator therapy. It may help researchers understand how these medications change hormone and blood sugar responses.
Cincinnati, OhioAges 18–45 - NCT06057714Recruiting
MRI study of airway function in cystic fibrosis
This study uses a special MRI technique (19F MRI) to look at how well your lungs are working and where any blockages are. The goal is to understand airway problems in cystic fibrosis better.
Chapel Hill, North CarolinaAges 18–99 - NCT05766774Recruiting
Diet study for adults with cystic fibrosis and high sugar intake
This trial studies whether changing eating habits—especially added sugar intake—affects health in adults with cystic fibrosis. It may help by testing a diet approach aimed at better outcomes related to metabolism and overall health.
Atlanta, GeorgiaAges 18 years+ - NCT05504837RecruitingPhase 1
Test KB407 inhaled treatment for adults with cystic fibrosis
This Phase 1 study tests the safety of KB407 and how it works in adults with cystic fibrosis (CF). It may help researchers understand whether this inhaled treatment could become a future option for CF.
Gainesville, FloridaAges 18 years+ - NCT05548283RecruitingPhase 4
Standard IV antibiotic timing for cystic fibrosis lung flare-ups
This study standardizes how IV aminoglycoside antibiotics are given during a 14-day treatment for cystic fibrosis (CF) lung flare-ups. It may help make treatment more consistent and easier to manage for people who need IV antibiotics.
Birmingham, AlabamaAges 6 years+ - NCT05279040Recruiting
Trikafta plus exercise program for adults with cystic fibrosis
This study tests how starting Trikafta affects exercise ability and breathing in adults with cystic fibrosis. You may be asked to do supervised breathing and exercise tests to see if Trikafta helps your lung function and stamina.
Vancouver, British ColumbiaAges 19 years+ - NCT05248230RecruitingPhase 2
Study drug for adults with cystic fibrosis lung disease
This Phase 2 trial tests 4D-710 to improve lung health in adults with cystic fibrosis who either cannot take CFTR modulator medicines or are not doing well enough on them. You may be eligible if you have moderate lung function and stable oxygen levels, and you meet other safety and health requirements.
Birmingham, AlabamaAges 18 years+ - NCT04732910Recruiting
Study of CFTR-modulator effects using body samples
This study looks at how well CFTR-modulator medicines are working in people with cystic fibrosis, by checking specific “biomarkers” (measurable signals) in samples. Your care team may use the results to better understand how these medicines help, especially for certain CFTR changes.
Berlin, State of BerlinAges 6 months+ - NCT01851694Recruiting
Study incretin hormone response in adults with cystic fibrosis
This study tests how the body’s “incretin” hormones affect insulin (sugar control) in adults with cystic fibrosis and certain blood sugar patterns. It may help explain what drives diabetes risk in cystic fibrosis and how the body responds to these hormone signals.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03921060RecruitingPhase 4
Check osteoporosis markers in people with cystic fibrosis
This study looks for signs (markers) of bone thinning—called osteoporosis—in people with cystic fibrosis. Your participation may help researchers understand how osteoporosis develops in CF and whether a bone-strengthening medicine like denosumab could help, since some participants may need that medication.
Dallas, TexasAges 18–64 - NCT03670472Recruiting
Gene therapy for cystic fibrosis with specific CFTR mutations
This study looks at correcting “stop” mistakes (nonsense mutations) in the CFTR gene, which can cause cystic fibrosis. If your CFTR test shows the exact type of mutation the study needs, you may be able to take part.
AmiensAges 8 years+ - NCT01852448Recruiting
Study genes affecting insulin in people with cystic fibrosis
This study looks at how genes may affect insulin and “incretin” hormones in people with cystic fibrosis. It may help researchers understand why some people develop blood-sugar problems and how to predict or prevent them.
Philadelphia, PennsylvaniaAges 2 years+ - NCT02965326Recruiting
Testing blood and swab markers to track new cystic fibrosis treatments
This study looks for simple signals (markers) that may show whether cystic fibrosis treatments are working. It includes people who take CF “modulator” medicines like ivacaftor, people who don’t, and people whose cystic fibrosis was ruled out after testing.
ParisAges Any age - NCT04700358Recruiting
Study of antibacterial antibodies in adults with cystic fibrosis
This study looks at how your body’s antibacterial antibodies work in people with cystic fibrosis. It may help researchers understand immune responses in cystic fibrosis and guide better future treatments.
CologneAges 18 years+ - NCT06526923RecruitingPhase 1/Phase 2
Testing SP-101 gene therapy for cystic fibrosis
This trial tests a new gene therapy called SP-101 for cystic fibrosis. It aims to see if SP-101 is safe and effective for improving lung function.
Kansas City, KansasAges 18–65 - NCT06313827Recruiting
Online program to prevent flare-ups in cystic fibrosis
This trial tests an online program designed to help people with cystic fibrosis avoid exacerbations (sudden worsening of symptoms). You participate from home using a device with internet, camera, and microphone.
ValenciaAges 6 years+ - NCT07369414Recruiting
NTM Germs in CF Homes: A Household Study
This study looks at whether people with cystic fibrosis (CF) can pick up nontuberculous mycobacteria (NTM) from their home environment. It compares homes of people with CF who have NTM to those who don't, to see where germs might be hiding.
Borstel, Schleswig-HolsteinAges Any age - NCT06915961Recruiting
HE4 Protein and Lung Function in Cystic Fibrosis
This study looks at a protein in the blood (HE4) and how it relates to lung function in children with cystic fibrosis. It also tests a quality improvement plan to help manage CF. The goal is to find better ways to track and treat the disease.
Cairo, AbbasiaAges 6 years+ - NCT07031323Recruiting
OnTrackCF: Using a smartphone app to help manage CF treatment
This study tests a smartphone app designed to help people with cystic fibrosis stay on track with their twice-daily CFTR modulator medication. Researchers want to see if the app is easy to use and helpful.
Birmingham, AlabamaAges 18 years+ - NCT05982795Recruiting
How CF modulators affect lung bacteria
This study looks at how highly effective CF modulator therapies change the bacteria living in the lungs of people with cystic fibrosis. Understanding these changes may help improve future treatments.
Lebanon, New HampshireAges 18–99 - NCT05998629Recruiting
Sweat sensor test for cystic fibrosis
This trial tests a new skin sensor that measures sweat to help diagnose cystic fibrosis. It compares results from people with CF and healthy volunteers to see if the device works accurately.
Hershey, PennsylvaniaAges 18–80
Hear when a new Cystic Fibrosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for cystic fibrosis?
- Yes. Clin2 currently lists 148 recruiting cystic fibrosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cystic fibrosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cystic fibrosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.