Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07716098RecruitingPhase 3
Esketamine nasal spray for treatment-resistant depression
This study tests esketamine nasal spray versus a placebo in adults with depression that has not improved after trying at least two other antidepressants. It aims to see if the spray can help when standard pills have not worked.
Redlands, CaliforniaAges 18 years+ - NCT07721753Recruiting
Online exercise and therapy for breast cancer mood
This study tests an online program that combines fun video-game exercises with talk therapy to help breast cancer patients who feel depressed or anxious. It takes place in Malaysia and is for Chinese-speaking adults.
Xinxiang, HenanAges 18 years+ - NCT05644301RecruitingPhase 3
Blood-marker guided add-on treatment for major depression
This study tests whether doctors can choose the best add-on immune-related treatment for people with major depressive disorder by using inflammation blood tests. It’s meant for people whose depression has not improved enough with their current antidepressant.
Duffel, AntwerpenAges 18–65 - NCT06363981Recruiting
Brain stimulation for depression, sleep and memory problems
This study tests a non-invasive brain stimulation treatment (called rTMS) to help with depression, sleep problems, and memory or concentration issues. It's designed for people with moderate to severe depression who also have trouble sleeping and thinking clearly.
KrakowAges 18–65 - NCT06371352Recruiting
Brain stimulation for sleep and fatigue in depression
This study tests a noninvasive brain stimulation treatment (theta burst stimulation) to see if it can improve sleep, reduce daytime sleepiness, and ease fatigue in people with depression.
WarsawAges 18–65 - NCT06628986Recruiting
Mindfulness and NLP for postpartum mood and breastfeeding
This study tests whether combining mindfulness (MBSR) and a gentle brain-training method (NLP) can help new mothers feel better after childbirth and improve their breastfeeding experience. It may be a good fit if you are a first-time mom who had a C-section and is breastfeeding.
Sanliurfa, Eyalet/YerleşkeAges 19–35 - NCT07706478Recruiting
Ketamine and Talk Therapy for Tough Depression
This trial tests whether a combination of ketamine (given through an IV) and talk therapy can help people with depression that hasn't responded to other treatments. If you have tried multiple antidepressants and therapy without success, this study may offer a new option.
Doorn, UtrechtAges 18–70 - NCT05648175Recruiting
Test an AI coaching tool versus a care team for depression
This study compares an artificial intelligence (AI) decision-making approach with support from a multi-professional care team for treating depression. It aims to see which approach helps people make better treatment choices and manage symptoms.
Kingston, OntarioAges 18 years+ - NCT07694076Recruiting
Real-time brain feedback for depression
This trial uses a powerful MRI scanner to give you real-time feedback on brain activity linked to depression. You will learn to regulate that activity, which may reduce symptoms.
OxfordAges 18–65 - NCT07691749Recruiting
Psychobiotics plus antidepressants for Major Depression
This study tests whether adding psychobiotics (special probiotics for mental health) to your current antidepressant helps treat major depression better than the antidepressant alone. It may be an option if you have moderate to severe depression and are on a stable antidepressant dose.
Lahore, Punjab ProvinceAges 18–60 - NCT07682207Recruiting
Accelerated brain stimulation for PTSD and depression
This study tests an accelerated form of brain stimulation called iTBS to see if it can help people with both PTSD and depression. It may be a good option if you have not found enough relief from your current treatments.
London, OntarioAges 18 years+ - NCT07687940Recruiting
Baduanjin exercise and green tea for mood in older adults
This study tests if doing gentle Baduanjin exercises and drinking green tea together can help improve mood and quality of life in older adults. It also looks at how this program affects gut health.
Kwun TongAges 65–84 - NCT07685925Enrolling by invitation
Health study for 2026 medical interns
This study tracks medical interns during their first year using a smartphone app. It aims to understand how internship affects health.
Ann Arbor, MichiganAges 18 years+ - NCT06658795Recruiting
Can brain stimulation help older adults with depression and loneliness?
This study tests whether a gentle brain stimulation technique called tDCS (transcranial direct current stimulation) can reduce loneliness in older adults with depression. It involves wearing a headband during sessions and comparing results to a placebo group.
Guangzhou, GuangdongAges 60–80 - NCT05961306Recruiting
Testing a stepped screening plan during pregnancy and after birth
This study checks how well a step-by-step screening approach and its tools work for identifying issues during pregnancy (weeks 20–24) or in early postpartum (6–10 weeks after delivery). It may help doctors use more accurate screening to decide who needs further care.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06078007Recruiting
App for depression and anxiety in college students
This trial tests if a guided mobile app can help college students with mild to moderate depression or anxiety. You might benefit if you are not currently receiving mental health treatment and have a smartphone.
Palma de Mallorca, Balearic IslandsAges 18 years+ - NCT07679204Recruiting
Personality and life satisfaction in bipolar and depression
This study looks at how personality traits and life satisfaction affect people with bipolar II disorder or major depression. You will fill out questionnaires about your feelings and daily life.
ElâzığAges 18 years+ - NCT07676851Recruiting
Predicting dementia risk in older adults with depression
This study looks at whether certain health factors can predict the risk of dementia in older adults who have depression. Your medical records will be reviewed to help create a risk score.
Nanchang, JiangxiAges 50 years+ - NCT06675851RecruitingPhase 4
Dopamine changes in the brains of depressed and healthy people
This study uses brain scans to look at dopamine — a chemical messenger related to reward and mood — in people with depression and healthy volunteers. Researchers want to understand how dopamine changes in depression, which may lead to better treatments.
ViennaAges 18–65 - NCT07655232Recruiting
Behavioral program for depression in nursing homes
This study tests a behavioral program designed to help skilled nursing facility residents with depression. The program aims to improve mood and quality of life.
Boston, MassachusettsAges 18 years+ - NCT06398496Recruiting
Exercise, gut health, mood in depression
This trial studies whether a 12-week exercise program can improve gut bacteria, mood, and thinking in people with depression. It may help if you are looking for a non-medication way to support your mental health.
Cork, Cork CountyAges 18–59 - NCT06565936Recruiting
PET/MRI brain scans for understanding depression
This trial uses two special brain scans (DPA-714 and FDG PET/MRI) to look at inflammation and brain activity in people with first-episode or recurrent depression, and in healthy volunteers. It aims to find brain differences that could lead to better treatments.
Dalian, LiaoningAges 35–85 - NCT07653113Enrolling by invitation
Music therapy for depression and anxiety in men
This trial tests whether a special type of music therapy, based on Chinese five-element theory, can help men with depression and anxiety. It is designed for male inpatients who have not taken antidepressants recently.
Shanxi, ShanxiAges 18–44 - NCT07646834Recruiting
Brain-Gut Study of IBS with Anxiety and Depression
This study explores how stress and mood changes affect irritable bowel syndrome (IBS) using brain imaging. Researchers will scan your brain and collect health information to understand the connection between your gut and mental health.
Xi'an, ShaanxiAges 18–60
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,419 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.