Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,420 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07639606Recruiting
Mobile therapy app for mood after recent stroke
This study tests whether using a smartphone or tablet app for cognitive behavioral therapy (a type of talk therapy you do on your device) can help with anxiety and depression in the first month after a stroke. The goal is to see if this convenient, at-home approach improves how you feel during early recovery.
New York, New YorkAges 18–79 - NCT07645157RecruitingPhase 2
Sertraline and Probiotics for Teen Depression
This study tests whether combining an antidepressant medication (sertraline) with special bacteria supplements (probiotics) can help treat depression in teenagers ages 12–18. Researchers believe the probiotics may help the medication work better by improving gut health.
Chongqing, YuzhongAges 12–18 - NCT07638553RecruitingPhase 3
Psilocybin to prevent alcohol relapse with depression
This study tests whether psilocybin (a psychedelic compound) can help people with severe alcohol use disorder stay sober longer, especially if they also have depression. Participants receive guided psilocybin sessions alongside counseling to reduce the risk of returning to heavy drinking.
BayonneAges 18 years+ - NCT07634705Recruiting
Digital app to help manage depression in primary care
This study tests a smartphone app called Moodivate that helps treat depression through your regular doctor's office using video visits. It's designed for people with mild-to-moderate depression who want a flexible, technology-based treatment option.
Charleston, South CarolinaAges 18 years+ - NCT07636694Recruiting
Brain Stimulation and Thinking Pattern Training for Depression
This study tests whether combining two treatments—magnetic brain stimulation (rTMS) and a computer program that helps retrain thought patterns—can reduce depression symptoms. You'll receive these treatments either together or one after the other to see which approach works best.
Quarry Bay, Hong Kong IslandAges Any age - NCT07633080Recruiting
Magnesium supplement added to antidepressants for depression
This study tests whether adding magnesium bisglycinate (a mineral supplement) to your current antidepressant medication can help improve depression symptoms. Researchers want to see if this combination works better than antidepressant alone.
Bhubaneswar, OdishaAges 18–65 - NCT07637773Recruiting
Brain Stimulation for Depression and Loss of Interest in Older Adults
This trial tests a new brain stimulation technique called tACS (transcranial alternating current stimulation) to treat depression in people aged 60 and older, especially the symptom of losing interest in things you once enjoyed. Researchers believe this targeted stimulation may help improve mood and motivation.
Tianjin, Tianjin MunicipalityAges 60 years+ - NCT06138678Recruiting
Accelerated TMS for severe depression
This trial tests an accelerated form of TMS (a treatment that uses magnetic pulses to stimulate the brain) for people with severe depression who have recently been in a psychiatric hospital. It aims to see if a faster schedule of TMS can help improve symptoms quickly.
KungälvAges 18 years+ - NCT07619092Recruiting
Flumazenil to reverse sedation during depression treatment
This trial tests whether flumazenil (a medication that reverses sedation from anti-anxiety drugs) can safely help patients wake up faster after electroconvulsive therapy (ECT), a treatment for severe depression. The goal is to see if it improves recovery time without causing problems.
Frederiksberg, Capital RegionAges 18 years+ - NCT05432362Recruiting
Energy sensing brain study in depression and weight groups
This study tests how the brain and body respond to “energy sensing” in people with depression and in people with different body weights. You may be asked to do assessments and follow specific health and diet rules so the researchers can compare groups.
Graz, StyriaAges 18–40 - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
Phoenix, ArizonaAges 18–75 - NCT07608796RecruitingPhase 2
JAK inhibitor for depression in male football players
This study tests a new medication (a JAK inhibitor) that may reduce brain inflammation and improve depression and thinking in male football players. It aims to see if this treatment helps with mood and cognitive function.
Atlanta, GeorgiaAges 30–55 - NCT07610369RecruitingPhase 2
Psilocybin therapy for depression in Parkinson's disease
This study tests whether psilocybin (a psychedelic compound) combined with therapy can reduce depression in people with Parkinson's disease. If you have moderate-to-severe depression and Parkinson's, this trial may offer a new treatment option.
New Haven, ConnecticutAges 40–80 - NCT07607613Recruiting
Support for LGBTQ+ Parents with Depression Risk
This study offers group support sessions for LGBTQ+ parents who are pregnant or recently had a baby and are experiencing mild depression or worry about postpartum depression. The goal is to help prevent depression from getting worse and improve emotional well-being during this important life transition.
Chicago, IllinoisAges 18 years+ - NCT07610655Recruiting
Nerve Stimulation to Aid Recovery After Spine Surgery
This study tests whether a small device that gently stimulates a nerve in your neck can help you recover better after lumbar spine surgery. The device may help reduce confusion, depression, and other thinking problems that sometimes occur after surgery.
Chicago, IllinoisAges 18 years+ - NCT06358495Recruiting
Sleep improvement to prevent depression and anxiety in teens
This study tests if improving sleep can help prevent depression and anxiety in teens who are at higher risk because a parent has had depression or anxiety. It's for teens who have trouble sleeping but don't have a history of depression or anxiety themselves.
Calgary, AlbertaAges 12–18 - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
Little Rock, ArkansasAges 18–74 - NCT07594743Recruiting
Digital app to prevent depression in new fathers
This study tests a smartphone app designed to help fathers manage stress and mood after their baby is born. Researchers want to see if fathers find the app helpful and easy to use during this major life change.
Providence, Rhode IslandAges 18 years+ - NCT05423275Recruiting
Light treatment to help you stop antidepressants safely
This study tests whether a “light and ion” treatment can help people with major depression (MDD) who are doing well on antidepressants safely reduce or stop them. You must be in remission and be willing to discontinue for reasons like side effects or personal preference.
Vancouver, British ColumbiaAges 19–65 - NCT07579481Recruiting
Vortioxetine for Depression with Migraine
This study tests whether vortioxetine, a depression medication, can help people who have both depression and episodic migraine (recurring headaches). You'd take vortioxetine for depression while researchers track how it affects both your mood and migraine symptoms.
Rome, LazioAges 18 years+ - NCT07579078Enrolling by invitation
Vitamin D and Brain Activity in Women With Depression
This study tests whether vitamin D supplements can improve brain wave patterns in women diagnosed with depression who have low vitamin D levels. Researchers will measure brain activity using EEG (a non-invasive test that records electrical signals from the brain) before and after vitamin D treatment.
DhakaAges 20–40 - NCT07573150Recruiting
Pupil Measurements to Predict Breathing Problems After Surgery in Children
This study tests whether measuring how a child's pupils (the dark circles in the eyes) respond to light can predict which children might have breathing problems after receiving pain medication during tonsil surgery. The goal is to help doctors catch and prevent serious breathing issues before they happen.
San Francisco, CaliforniaAges 3–17 - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Bryant, ArkansasAges 18–74 - NCT07574060RecruitingPhase 2/Phase 3
Allopurinol as an Add-On Treatment for Depression
This trial tests whether allopurinol, a medication typically used for gout, might help reduce depression symptoms when added to standard depression treatment. Researchers believe it may work by reducing inflammation in the brain that contributes to depression.
TantaAges 18–60
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,420 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.