Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06651554Recruiting
Suicide prevention app study for teens in Bogota
This trial tests a digital platform designed to help prevent suicide among teenagers. It aims to make mental health support more accessible for students in Bogota schools.
Bogotá, ColombiaAges 14–19 - NCT05663034Recruiting
Compare CBT-I vs MBTI for sleep and trauma symptoms after TBI
This study compares two types of talk-based therapy to help veterans with long-lasting insomnia after a traumatic brain injury (TBI), and also looks at related post-trauma stress symptoms. It may help you improve sleep and reduce how much these symptoms affect daily life.
Eglin Air Force Base, FloridaAges 18 years+ - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Phoenix, ArizonaAges 18–85 - NCT05859204Enrolling by invitation
Exercise groups to improve mental health in hospital
This study tests whether joining structured exercise groups while you’re an inpatient in a psychiatric unit can improve mood, mental wellbeing, and overall comfort. It’s designed to be adjustable for different mobility needs and to be safe for participating patients.
Baltimore, MarylandAges 18 years+ - NCT04940585Recruiting
Study for pregnant women with stress or depression symptoms
This study supports pregnant people who are in their second trimester and have signs of stress, trauma, or depression. The goal is to learn whether the program can help improve emotional well-being during pregnancy.
New York, New YorkAges 18–100 - NCT04956016Recruiting
Compare two rTMS treatments for moderate to severe depression
This study tests whether a classic type of brain stimulation (rTMS) works better or the same as a deeper version for depression that keeps coming back or is ongoing. You may be offered one of the two stimulation options to see which helps reduce depressive symptoms.
PoitiersAges 18 years+ - NCT05004987RecruitingPhase 4
Study brain and blood changes in older adults with depression
This study looks at how a brain protein linked to Alzheimer’s disease changes over time in older adults who have major depression but no major memory problems. It involves brain scans, blood and urine tests, and a spinal fluid sample to better understand the connection between depression and brain aging.
New York, New YorkAges 60 years+ - NCT05009433Recruiting
Exercise plans in pregnancy and afterward for mom and baby health
This study compares two types of exercise—short, intense intervals versus moderate steady activity—during pregnancy and looks at effects on mothers and children. It also checks how participants do on health, fitness, and well-being tests before, during, and after pregnancy.
Gdansk, Pomeranian VoivodeshipAges 18–45 - NCT05066308RecruitingPhase 2
Cannabidiol to reduce inflammation in chronic low back pain
This Phase 2 study tests cannabidiol (CBD) to calm inflammation in the brain that may be linked to chronic low back pain. If you qualify, you’ll take study CBD and undergo brain imaging to see whether inflammation changes.
Boston, MassachusettsAges 18–75 - NCT05074901Recruiting
Using a health app in France with virtual support
This trial tests whether a digital health app (with “virtual agents,” like guided prompts/support) can improve people’s health outcomes. You may help the study by using the app and completing its questionnaires.
BordeauxAges 18 years+ - NCT05094297Recruiting
Study of muscle contraction training for veteran tiredness and pain
This study tests whether a guided exercise approach using focused muscle contractions can improve pain, fatigue, or low energy in U.S. Veterans. If you’re having trouble doing everyday activities, this program may help you feel better and function more easily.
Chicago, IllinoisAges 18 years+ - NCT05117255Recruiting
Online therapy study for anxiety in residential alcohol treatment
This study tests an internet-based, interactive version of cognitive behavioral therapy (CBT) for anxiety symptoms. It’s designed for people getting mainly alcohol-focused treatment in a residential program, to see if the online approach works and is feasible for you.
Minneapolis, MinnesotaAges 18–65 - NCT05156385Recruiting
Study of sexual problems in women with treated high blood pressure
This study looks at sexual dysfunction (sexual problems) in women who are being treated for high blood pressure. It may help researchers understand what causes these issues and what could improve them.
Toulouse, CHU de ToulouseAges 18 years+ - NCT05176392Recruiting
Stimulation treatment plus therapy for post-injury headaches
This study tests whether a noninvasive brain stimulation treatment combined with therapy can reduce long-lasting headaches after a mild brain injury. You might be a good candidate if your headaches started after the injury and have continued for months.
San Diego, CaliforniaAges 18–65 - NCT05232032RecruitingPhase 2
Brain scan and medication study for avoiding versus approaching
This Phase 2 study looks at how a medication affects brain activity and real-life mood or anxiety behaviors. It includes people with major depression or several anxiety disorders and also healthy volunteers, using questionnaires, a smartphone, and brain imaging.
Belmont, MassachusettsAges 18–45 - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT05268588Recruiting
Post-birth health texting study during late pregnancy
This study tests whether phone-based (mHealth) messages and support can improve health after you give birth. It may help you stay informed and get support during the weeks right after delivery.
Chandīgarh, HaryanaAges 18–49 - NCT05282277RecruitingPhase 4
Estradiol to improve brain and reward changes in midlife women
This study tests whether a hormone called estradiol (given as a patch and pill) changes how the brain and body respond to reward in some midlife women with low pleasure and/or psychosis symptoms during menopause transition. It may help researchers understand whether estrogen treatment can improve mood-related “reward” function in this group.
Chapel Hill, North CarolinaAges 45–55 - NCT05288140Recruiting
Using daily diaries for people in the intensive care unit
This study checks whether keeping a daily diary for people in the intensive care unit can help after an ICU stay. You may be eligible if you are in the ICU, are sedated and on a breathing machine for at least 24 hours, and can agree to follow-up visits.
BarcelonaAges 18–100 - NCT05306834Recruiting
Study to slow memory decline by targeting hidden small brain vessel disease
This trial looks at how to slow cognitive decline and early dementia in people with a specific kind of “silent” blood vessel damage in the brain seen on scans. It may help identify whether targeting this hidden condition can protect thinking and memory over time.
BordeauxAges 60–88 - NCT05322343Recruiting
Study biobank and brain health in people age 55–80
This study collects blood samples to build a biobank and learn how brain health changes with age. Some participants may also do an MRI scan to better understand brain changes and immune response.
Bordeaux, BordeauxAges 55–80 - NCT05323864Recruiting
Altitude exposure study for anxiety and low mood
This trial looks at what happens to people with anxiety and depressive symptoms after going to high altitude with low oxygen. It may help researchers understand whether altitude affects these symptoms and how it might be managed.
Innsbruck, TyrolAges 18–65 - NCT05327699RecruitingEarly Phase 1
Ketamine study for depression with reduced pleasure
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Atlanta, GeorgiaAges 18–65 - NCT05333627Recruiting
Online therapy program trial for student depression or anxiety
This trial tests an internet-based therapy program to help students with depression or anxiety. If you qualify, you’ll complete online sessions and assessments to see whether the program helps with symptoms and how long you prefer to use it.
Regina, SaskatchewanAges 18 years+
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,509 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.