Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05366270Recruiting
Testing how mild heat affects depression symptoms and brain signals
This study tests whether controlled whole-body heat can change immune-related brain and body signals in people with major depressive disorder. It may help researchers understand why heat affects mood and who might benefit, while closely monitoring safety.
Boston, MassachusettsAges 18–65 - NCT05369195Recruiting
Protecting the brain during a heart procedure for atrial fibrillation
This trial studies a way to help protect the brain during a catheter procedure that closes the left atrial appendage (a small heart pouch) in people with atrial fibrillation. It may help lower the risk of stroke-related brain injury for patients who can’t safely take blood thinners.
KatowiceAges 18 years+ - NCT05369429Recruiting
Stress and mood support program for adults with cancer
This trial tests a new online “wellbeing guide” to help manage stress and improve quality of life. It focuses on adults with cancer who also have higher-than-usual depressive symptoms.
Chicago, IllinoisAges 18 years+ - NCT05379673Recruiting
Breathing changes with extra oxygen after surgery
This study looks at whether giving extra oxygen during recovery from general anesthesia changes how you breathe after surgery. You may be offered different oxygen levels around the time you wake up to see what helps your breathing most comfortably.
Stanford, CaliforniaAges 18–70 - NCT05384158Recruiting
Testing a computer game for low mood, low pleasure, or anxiety
This trial looks at how a computer-based task performs when someone is dealing with depression-like symptoms, such as low mood, low interest/pleasure, or anxiety that affects daily functioning. You might find it helpful if you fit their symptom and safety requirements and are comfortable with computer tasks and (for some parts) MRI scanning.
Roanoke, VirginiaAges 25–50 - NCT05388461Recruiting
Follow-up after ECT for major depression
This study checks how well electroconvulsive therapy (ECT) works for people with major depression right after treatment and again 6 months later. You may be able to take part if you had ECT for major depression at the specified hospitals and agree to be included in a neurostimulation follow-up registry.
BergenAges 18 years+ - NCT05409794Recruiting
Testing blood lithium levels in people with depression and suicidality
This study checks how much lithium is naturally present in the blood and whether that relates to suicidal thoughts or attempts in people with a current major depressive episode. It may help researchers understand biological factors linked to suicide risk and improve future prevention.
MontpellierAges 18 years+ - NCT05418894Recruiting
Study brain signals and improve treatment-resistant depression
This trial studies how brain activity relates to feelings and depression, using brain electrodes to measure signals. It’s meant for people with long-lasting, treatment-resistant major depression who may need stimulation while continuing psychiatric care.
Houston, TexasAges 22–70 - NCT05434130RecruitingPhase 2
Testing the right exercise amount to help concussion recovery
This study tests whether adjusting how much exercise you do can improve recovery after a concussion. You may be screened to make sure symptoms are still present, and then assigned to an exercise plan that matches the study’s goals.
Aurora, ColoradoAges 13–18 - NCT05437705Recruiting
Brain scan and stimulation study for low mood
This study uses brain imaging (MRI) and a brain-stimulation method (TMS) to understand and possibly change brain patterns linked with low mood. You may be eligible if you have moderate to severe depression symptoms and can safely complete the scans and stimulation sessions.
Philadelphia, PennsylvaniaAges 18–65 - NCT05447689Recruiting
Group mind-body skills for anxious graduate students
This trial offers a weekly group program teaching mind-body skills to help reduce anxiety. It’s for graduate students who screen as having moderate or higher anxiety and can attend meetings regularly.
White Plains, New YorkAges 18 years+ - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT05461092RecruitingEarly Phase 1
Nerve blocks to improve pain control after spinal fusion
This early-stage study tests whether a regional nerve block can improve pain control and recovery for older adults having elective lumbar spinal fusion. If you qualify, you may receive a special pain-control injection during surgery to reduce opioid needs and improve recovery comfort.
Iowa City, IowaAges 65 years+ - NCT05474846RecruitingPhase 2/Phase 3
Combination treatment to improve sleep in advanced cancer
This trial tests a combination approach to improve poor sleep in people with advanced cancer. If you qualify, you would answer sleep and symptom questions and may do a structured therapy (CBT) plus follow-up visits.
Houston, TexasAges 18 years+ - NCT05480150Recruiting
Study of brain and mood in people with depression or bipolar disorder
This study is following and assessing people with major depression or bipolar disorder to better understand the condition and how the brain relates to symptoms. It may help researchers develop more targeted support by comparing brain and health information over time.
Hangzhou, ZhejiangAges 16–65 - NCT05480826Recruiting
Family genetic study for mood, thinking, and autism conditions
This study looks at genetic changes found in people with conditions like bipolar disorder, schizophrenia, depression, or autism, and compares how those genetic differences may function. It may help researchers understand the causes of these conditions using information from patients and their relatives.
CréteilAges 18 years+ - NCT05485701Recruiting
Study of perinatal mental health in India
This study looks at mental health during pregnancy and after birth, and may help improve how these concerns are understood and assessed. You may be interviewed or asked to complete surveys across a few visits, depending on which part of the study you join.
Kangra, Himachal PradeshAges 18–45 - NCT05489042Recruiting
Brain scan and rTMS study for suicidal thoughts in opioid users
This study looks at brain connectivity using an MRI scan and then treats some people with rTMS (a non-surgical brain stimulation). It’s designed for adults who use opioids and currently have active suicidal thoughts, to better understand and help those symptoms.
Houston, TexasAges 18–64 - NCT05491538Recruiting
Work skills training for Veterans living with serious mental illness
This study tests whether a social-skills training program designed for work goals is doable and helpful for Veterans with serious mental illness. It focuses on improving work-related coping and interactions while you receive supported services through the VA.
Minneapolis, MinnesotaAges 18 years+ - NCT05497115Recruiting
Care model to improve access to mental health after trauma
This trial tests a practical care plan to help people get mental health support after a traumatic injury, especially if screening suggests risk for PTSD or depression. It may help you connect faster to the right kind of treatment after your injury.
Washington, VirginiaAges 16 years+ - NCT05527509Recruiting
Study of risk and resilience in new RCMP cadets
This study follows people as they start RCMP Cadet Training to learn what factors affect “risk” and “resilience” (how well someone adapts under stress). It may help improve support for cadets during training.
Regina, SaskatchewanAges 19–57 - NCT05538910Recruiting
Study brain links between depression and substance use
This study uses brain imaging and questionnaires to understand how substance use and depression are connected in the brain. It may help researchers identify biological patterns that could guide better treatments in the future.
Baltimore, MarylandAges 18–60 - NCT05555875Recruiting
Study how people engage with digital mental health tools
This study looks at what helps (or prevents) people from using digital mental health programs. You may join if you have meaningful depression and/or anxiety symptoms and you can use a smartphone for the study apps.
Boston, MassachusettsAges 18–75 - NCT05563805Recruiting
Virtual reality adventure training for movement and fitness
This study uses a virtual reality “adventure” game that gets you moving to train exercise skills and coordination. It’s designed for U.S. military veterans who can walk on their own and don’t have certain vision, balance, or medical limits.
Arlington, TexasAges 18–45
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,509 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.