Clinical trials
Depression Disorders clinical trials
Below are recruiting depression disorders clinical trials, each written for real people, not researchers. We’re tracking 669 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06820723RecruitingPhase 2
Testing a single dose of CYB003 for depression and anxiety
This trial tests a single dose of an investigational drug (CYB003) in people with depression and anxiety who haven't gotten enough help from their current antidepressant. You would take a psilocybin-like medication and be monitored for how it affects your mood and anxiety.
Columbus, OhioAges 21–65 - NCT05800925Recruiting
Triage survey to check who can join psychiatry research
This study uses a short questionnaire to figure out who is eligible to join future psychiatry research. It may help people get routed into studies that match their situation and safety needs.
Boston, MassachusettsAges 18 years+ - NCT04996433Recruiting
Compare two talk therapy programs for treatment-resistant depression
This study compares two psychotherapy programs to help people who have ongoing, difficult-to-treat depression while in inpatient care. If you qualify, you’ll receive one of the therapy programs and be followed to see which approach helps depression symptoms more.
Berlin, State of BerlinAges 18–75 - NCT06005766Recruiting
Metacognitive skills training in forensic psychiatric care
This study tests if a specialized training program can help people with psychosis (like schizophrenia) who are in forensic psychiatric care. The training focuses on improving how you think about your own thoughts, which may help you manage symptoms better.
VaasaAges 18 years+ - NCT07255131Recruiting
Online talk therapy for cystic fibrosis
This study tests an online cognitive behavioral therapy (a type of talk therapy) program designed for people with cystic fibrosis. It aims to help improve mental health and coping skills through 13 video sessions.
AthensAges 18–70 - NCT06442423RecruitingPhase 1
Psilocybin study for people with psychiatric symptoms
This trial tests if psilocybin, a substance found in certain mushrooms, can help people with various mental health symptoms that affect daily life. You would take a single dose in a supervised setting and be monitored for changes in your mood and well-being.
New Haven, ConnecticutAges 18 years+ - NCT07373470Recruiting
Pharmacist help with depression meds using your DNA
This trial tests whether a pharmacist can use your genetic information to better manage your depression medications. It may help find the right drug or dose for you.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06740396Recruiting
Depression in heart disease patients in Baghdad
This study looks at how common depression is in people with coronary artery disease and how severe it is. If you have heart disease and are being treated at a hospital in Baghdad, you can help doctors understand the link between heart health and mental health.
BaghdadAges 18 years+ - NCT07127913Recruiting
Closed-loop brain stimulation for hard-to-treat bipolar depression
This trial tests a closed-loop deep brain stimulation system for people with bipolar II disorder whose depression has not responded to standard treatments. The device sends targeted electrical pulses to the brain based on real-time activity, aiming to reduce depression symptoms.
San Francisco, CaliforniaAges 22–70 - NCT05437588Recruiting
Blood-based biomarkers for suicide risk in teens with depression
This study looks at tiny blood particles (exosomes) and specific microRNAs to see if they can signal suicide risk and predict treatment outcomes in adolescents. If you qualify, your blood may be used to help researchers find better ways to understand and track suicidality and depression treatment response.
Birmingham, AlabamaAges 10–24 - NCT07876908Recruiting
Magnetic brain therapy for older adults with hard-to-treat depression
This trial tests a new intensive magnetic brain treatment (SAINT) for older adults whose depression has not improved with standard treatments. It aims to see if this treatment can also help with memory concerns, which are common in this group.
Costa Mesa, CaliforniaAges 65 years+ - NCT04685148RecruitingPhase 1/Phase 2
Study of mental health treatment during pregnancy
This trial studies a treatment aimed at improving maternal mental health during pregnancy. It focuses on people who have had depression around pregnancy before, and checks whether the approach is safe and helpful for them.
CopenhagenAges 18–45 - NCT06187454Recruiting
Brain stimulation for depression
This trial tests if a gentle brain stimulation called tDCS can help people with depression who haven't gotten better from antidepressants. It uses a small current on the scalp to try to improve mood.
TaipeiAges 60 years+ - NCT07819448Recruiting
Aerobic exercise added to depression treatment
This study tests whether adding aerobic exercise (like walking, jogging, or cycling) to your usual depression treatment helps improve your mood. It is for adults with moderate or severe depression who are not already exercising regularly.
Chak Four Hundred Fifty-four, Punjab ProvinceAges 18–55 - NCT07716098RecruitingPhase 3
Esketamine nasal spray for treatment-resistant depression
This study tests esketamine nasal spray versus a placebo in adults with depression that has not improved after trying at least two other antidepressants. It aims to see if the spray can help when standard pills have not worked.
Redlands, CaliforniaAges 18 years+ - NCT07691749Recruiting
Psychobiotics plus antidepressants for Major Depression
This study tests whether adding psychobiotics (special probiotics for mental health) to your current antidepressant helps treat major depression better than the antidepressant alone. It may be an option if you have moderate to severe depression and are on a stable antidepressant dose.
Lahore, Punjab ProvinceAges 18–60 - NCT06398496Recruiting
Exercise, gut health, mood in depression
This trial studies whether a 12-week exercise program can improve gut bacteria, mood, and thinking in people with depression. It may help if you are looking for a non-medication way to support your mental health.
Cork, Cork CountyAges 18–59 - NCT07333027Recruiting
Loneliness in depression treatment study
This study looks at how loneliness affects people hospitalized for depression. It may help researchers understand how to better support recovery.
Erlangen, BavariaAges 18 years+ - NCT07316803Recruiting
Group therapy for romantic relationships in young adults with mental illness
This study tests a group program to help young adults with serious mental health conditions build skills for romantic and social relationships. It may be a good fit if you are single, motivated to work on relationships, and have received mental health care recently.
Épinay-sur-Seine, Île-de-France RegionAges 18 years+ - NCT06728280Recruiting
DTMS for teens with depression: safety and effectiveness
This trial tests if a new type of brain stimulation called DTMS can safely help adolescents with major depression. It may be an option if you have tried other treatments and are looking for a non-medication approach.
Taiyuan, ShanxiAges 11–23 - NCT05076214Recruiting
Exercise group for teens with mild to moderate depression
This study compares a structured aerobic exercise group to a more relaxed leisure activity group for adolescents with mild to moderate depression. It aims to see whether exercise can help improve mood when earlier basic support didn’t work well enough.
HalmstadAges 13–17 - NCT07185815RecruitingPhase 1/Phase 2
Study of a long-acting cariprazine shot for mood and schizophrenia
This trial tests a monthly injection of cariprazine (a medication for mental health conditions) in people who could benefit from it. It aims to see if the shot is safe, tolerable, and effective compared to taking pills every day.
AhmedabadAges 18–64 - NCT03601026Recruiting
Genetic counseling for youth using cannabis safely
This study offers genetic counseling to help reduce mental health problems that can happen for some young people who use cannabis. You join if you are already part of the FORBOW study and fit their age and mental-health criteria.
Halifax, Nova ScotiaAges 12–21 - NCT04057378RecruitingPhase 4
Testing the best electrical settings for ECT for depression
This trial studies which electrical “pulse settings” work best during electroconvulsive therapy (ECT) for people with depression. It may help doctors personalize ECT so the treatment is safer and works as well as possible for you.
ÖrebroAges 18 years+
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Common questions
- Are there clinical trials for depression disorders?
- Yes. Clin2 currently lists 669 recruiting depression disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.