Clinical trials
Depression Disorders clinical trials
Below are recruiting depression disorders clinical trials, each written for real people, not researchers. We’re tracking 689 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07500714Recruiting
Digital therapy for depression using AI
This study uses a smartphone app and artificial intelligence to deliver a special type of talk therapy for people with moderate to severe depression. It aims to provide personalized care without needing to change your current treatment.
Taichung, TaichungAges 18–75 - NCT06542094Recruiting
Brain stimulation for severe depression that hasn't improved with other treatments
This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
Chengdu, SichuanAges 18–65 - NCT05480826Recruiting
Family genetic study for mood, thinking, and autism conditions
This study looks at genetic changes found in people with conditions like bipolar disorder, schizophrenia, depression, or autism, and compares how those genetic differences may function. It may help researchers understand the causes of these conditions using information from patients and their relatives.
CréteilAges 18 years+ - NCT07247344Recruiting
Depression in hospitalized teens: a brain study
This study looks at brain and behavior in teens aged 10–20 who are hospitalized for depression or bipolar disorder. It aims to better understand the condition and may help guide future treatments.
Nanjing, JiangsuAges 10–20 - NCT06529029RecruitingPhase 2/Phase 3
Comparing new low-pulse ECT to standard ECT for depression
This trial tests a new type of seizure therapy (low amplitude pulse seizure therapy) against the standard ultra-brief right unilateral ECT for people with severe depression, including those with suicidal thoughts. The goal is to see which treatment works better.
Grand Rapids, MichiganAges 18–90 - NCT06038721Recruiting
Unified Protocol for kids with emotional concerns
This trial tests a program called Unified Protocol for children ages 7–17 who have emotional difficulties like anxiety, depression, trauma, or obsessive-compulsive symptoms. It aims to help kids and their parents learn skills to manage these feelings together.
Coral Gables, FloridaAges 7–17 - NCT07211217Recruiting
Time-restricted eating for bipolar depression
This study tests if eating only during a specific daily window can help with weight loss and mood in people with bipolar disorder who are currently depressed and overweight.
Boston, MassachusettsAges 18–65 - NCT00762866Enrolling by invitation
Study of mental health traits using genetic and brain measurements
This study collects information about mental health symptoms and body/genetic samples to better understand how different mental health conditions are related. Some people may also have brain scans (PET or MRI) if they can safely complete them.
Nashville, TennesseeAges 16–65 - NCT07234851Enrolling by invitation
Brain tissue study of synaptic loss in mental and brain diseases
This study looks at how brain connections break down in people with psychiatric disorders (like schizophrenia, depression, or bipolar disorder) or neurodegenerative diseases (like Alzheimer's or frontotemporal dementia). It uses donated brain tissue after death to understand why symptoms occur.
BarcelonaAges 40 years+ - NCT05553353Recruiting
Repeated brain stimulation for depression after spinal cord injury
This study tests a non-drug treatment called repeated transcranial magnetic stimulation (rTMS) to reduce depression symptoms in people with depression after a spinal cord injury. You might be eligible if you have ongoing major depression and can safely receive magnetic pulses to the head.
Charleston, South CarolinaAges 18–60 - NCT06086366Recruiting
Brain scan study for depression after COVID-19
This study uses brain scans to understand depression that starts soon after COVID-19. Researchers want to see if there are changes in brain chemistry related to depression, and you may help find new treatment targets.
Toronto, OntarioAges 18–75 - NCT06507787Recruiting
Blood test for depression vs. bipolar disorder
This study tests a new blood test (EDIT-B®) to help doctors tell the difference between depression and bipolar disorder. If you have a depressive episode but there is doubt about bipolar disorder, this test might help guide your treatment to improve your health.
ErsteinAges 18–65 - NCT07533773Recruiting
Brain Activity Changes After Depression Treatment
This study measures how brain activity in specific regions changes after you receive electroconvulsive therapy (ECT) or magnetic seizure therapy (MST) for severe depression. Researchers use a non-invasive headband to monitor blood flow in your brain before and after treatment to better understand how these therapies work.
Hefei, AnhuiAges 12–65 - NCT07007247Enrolling by invitation
Digital aftercare for teens with depression after hospital discharge
This pilot study tests a digital program to support adolescents aged 12–17 with depression after they leave the hospital. It aims to help prevent relapse and improve well-being using a smartphone, tablet, or computer.
HamburgAges 12–17 - NCT06671977RecruitingPhase 1
Safety and effects of DMT in healthy adults and those with depression
This trial studies the safety and effects of DMT, a psychedelic compound, in healthy volunteers and people with major depressive disorder (MDD) who haven't responded well to antidepressants. It aims to see how DMT affects the brain and mood.
West Haven, ConnecticutAges 21–65 - NCT07018245RecruitingPhase 2
TJ0113 Capsule for depression: a phase 2 study
This trial tests an investigational medication called TJ0113 for people with moderate to severe depression. It aims to see if the drug can safely improve depression symptoms when other treatments are stopped during the study.
Hangzhou, ZhejiangAges 18–65 - NCT06508450Recruiting
Mental health support for minority young adults
This trial tests a program to help racial and ethnic minority young adults engage with mental health services. It aims to improve access and participation in care.
The Bronx, New YorkAges 18–34 - NCT06898593Recruiting
Including patient goals in collaborative care
This trial looks at ways to better include your personal goals and concerns in your care if you're already in the Collaborative Care Model at Dartmouth Health. It aims to make your treatment more focused on what matters to you.
Concord, New HampshireAges 18–100 - NCT07062042Recruiting
Empowering narratives for Ukrainian refugees in Norway
This study tests a therapy program for Ukrainian refugees in Norway who have PTSD symptoms or have experienced trauma. It aims to help participants by exploring personal stories and coping strategies.
OsloAges 18 years+ - NCT07290153Recruiting
Psychological health and immunotherapy for TNBC
This study looks at how psychological factors and the immune system affect treatment response in women with triple-negative breast cancer. Researchers will use questionnaires and biological samples to understand these links.
Shanghai, Please SelectAges 18–70 - NCT05570812RecruitingPhase 2
Pregnenolone to improve depressed mood in people with HIV
This Phase 2 trial tests a brain-acting steroid called pregnenolone to help reduce depressed mood. It studies whether it can improve mood in adults with HIV who are already on HIV treatment and still have depression symptoms.
Boston, MassachusettsAges 18–85 - NCT06928480Recruiting
Unified Protocol for Emotional Health in Long COVID
This study tests a program to help people with Long COVID manage emotional difficulties like depression or anxiety. It combines different therapy approaches into one treatment, which you can receive online from home.
Zaragoza, ZaragozaAges 18 years+ - NCT06820723RecruitingPhase 2
Testing a single dose of CYB003 for depression and anxiety
This trial tests a single dose of an investigational drug (CYB003) in people with depression and anxiety who haven't gotten enough help from their current antidepressant. You would take a psilocybin-like medication and be monitored for how it affects your mood and anxiety.
Columbus, OhioAges 21–65 - NCT04996433Recruiting
Compare two talk therapy programs for treatment-resistant depression
This study compares two psychotherapy programs to help people who have ongoing, difficult-to-treat depression while in inpatient care. If you qualify, you’ll receive one of the therapy programs and be followed to see which approach helps depression symptoms more.
Berlin, State of BerlinAges 18–75
Hear when a new Depression Disorders trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for depression disorders?
- Yes. Clin2 currently lists 689 recruiting depression disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.