Clinical trials
Depression - Major Depressive Disorder clinical trials
Below are recruiting depression - major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 204 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06898593Recruiting
Including patient goals in collaborative care
This trial looks at ways to better include your personal goals and concerns in your care if you're already in the Collaborative Care Model at Dartmouth Health. It aims to make your treatment more focused on what matters to you.
Concord, New HampshireAges 18–100 - NCT07062042Recruiting
Empowering narratives for Ukrainian refugees in Norway
This study tests a therapy program for Ukrainian refugees in Norway who have PTSD symptoms or have experienced trauma. It aims to help participants by exploring personal stories and coping strategies.
OsloAges 18 years+ - NCT07290153Recruiting
Psychological health and immunotherapy for TNBC
This study looks at how psychological factors and the immune system affect treatment response in women with triple-negative breast cancer. Researchers will use questionnaires and biological samples to understand these links.
Shanghai, Please SelectAges 18–70 - NCT06928480Recruiting
Unified Protocol for Emotional Health in Long COVID
This study tests a program to help people with Long COVID manage emotional difficulties like depression or anxiety. It combines different therapy approaches into one treatment, which you can receive online from home.
Zaragoza, ZaragozaAges 18 years+ - NCT04996433Recruiting
Compare two talk therapy programs for treatment-resistant depression
This study compares two psychotherapy programs to help people who have ongoing, difficult-to-treat depression while in inpatient care. If you qualify, you’ll receive one of the therapy programs and be followed to see which approach helps depression symptoms more.
Berlin, State of BerlinAges 18–75 - NCT06005766Recruiting
Metacognitive skills training in forensic psychiatric care
This study tests if a specialized training program can help people with psychosis (like schizophrenia) who are in forensic psychiatric care. The training focuses on improving how you think about your own thoughts, which may help you manage symptoms better.
VaasaAges 18 years+ - NCT07333027Recruiting
Loneliness in depression treatment study
This study looks at how loneliness affects people hospitalized for depression. It may help researchers understand how to better support recovery.
Erlangen, BavariaAges 18 years+ - NCT06775548Enrolling by invitation
Exercise and vitamins for depression relief
This study tests if combining aerobic and resistance exercises with vitamins D and E can reduce stress and inflammation in people with mild to moderate depression. It may help improve mood and overall well-being.
Karachi, SindhAges 25–35 - NCT05570344Recruiting
Texting support plus brain stimulation for hard-to-treat depression
This study tests whether adding supportive text messages to brain stimulation (repetitive TMS) helps people with depression that has not improved after at least two antidepressant tries. It may help some people by combining a brain-based treatment with ongoing daily encouragement and support.
Edmonton, AlbertaAges 18 years+ - NCT05962216Recruiting
Real-world check of Rexulti for schizophrenia and depression
This study looks at how well brexpiprazole (Rexulti) works in everyday treatment, and how people feel and function over time. You may be eligible if you’re newly started on Rexulti and have a qualifying mental health diagnosis.
Hong KongAges 18–65 - NCT06833567Recruiting
Mentalizing therapy for anxiety and depression
This study tests a group therapy that helps people understand their own and others' thoughts and feelings. It may help if you have anxiety or depression and can talk in a group setting.
Málaga, MalagaAges 18 years+ - NCT00024635Recruiting
Understanding Mood and Anxiety Disorders Study
This research study evaluates people with mood disorders (like depression or bipolar disorder), anxiety disorders, or people without these conditions to better understand how these conditions develop and affect the brain. Researchers will ask questions and may do other assessments to learn more.
Bethesda, MarylandAges 3–99 - NCT07216638Enrolling by invitation
Better mental health care for kids in primary care
This trial studies how to better integrate mental health care into pediatric primary care clinics across Indiana. It involves surveys, interviews, and looking at patient records to understand and improve care for children.
Indianapolis, IndianaAges 5 years+ - NCT07590115Enrolling by invitation
Behavioral Patterns and Treatment Success in Substance Use Recovery
This study looks at how behavioral patterns change during residential treatment for substance use disorder. Researchers will track your progress over several weeks to understand what helps people succeed in recovery.
Potrerillos, JaliscoAges 18–60 - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Bentonville, ArkansasAges 10–17 - NCT06488573Recruiting
Nutrition program to improve heart health in bipolar disorder
This study tests if a nutrition program can help people with bipolar disorder improve their heart health. It is for adults aged 18 to 60 with bipolar I or II who are already on medication and are at moderate or high risk for heart problems.
São Paulo, São PauloAges 18–60 - NCT07753473Recruiting
Brain stimulation for young adults with depressive symptoms
This study uses a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to see if it can improve how the brain and heart work together in people aged 18 to 30 who have mild depressive symptoms. The goal is to understand if this treatment could help with mood regulation.
Xi'an, ShaanxiAges 18–30 - NCT07218263Recruiting
AI app to detect fatigue and depression
This trial studies whether an AI-powered app can help detect signs of fatigue and depression. It may be a good fit if you are an adult who can speak English and are willing to try the app.
Indianapolis, IndianaAges 18–99 - NCT03217110Recruiting
Brain stimulation study for thinking and control
This trial tests whether stimulating the cerebellum (a part of the brain involved in coordination and learning) can improve “cognitive control,” or the ability to focus and manage thoughts. You may be able to join if you have a diagnosis they are specifically enrolling for and you can safely complete the stimulation and study procedures.
Iowa City, IowaAges 18–90 - NCT05816304Recruiting
Digital CBT for insomnia in frontline health care workers
This study tests whether an online, structured “talk-therapy style” program (digital cognitive behavioral therapy for insomnia) can improve sleep for frontline health care workers. If you have probable insomnia and can use a phone or computer, the program may help you sleep better without in-person visits.
Toronto, OntarioAges Any age - NCT06038409Recruiting
Ketamine therapy for chronic conditions
This trial tests if ketamine can help people with long-term health issues. It aims to find new treatments for chronic conditions that haven't responded well to other therapies.
Helena, MontanaAges 18 years+ - NCT06995807Recruiting
EL-SHIN therapy for depression and stress
This trial tests a new therapy called EL-SHIN for people with moderate depression, anxiety, and stress. It may help if you are a non-Muslim who believes in creationism.
Kuala LumpurAges 18 years+ - NCT07100951Recruiting
Comparing two couples therapies for relationship distress
This study compares two types of couples therapy to see which is better at reducing relationship distress. If you and your partner are feeling unhappy or struggling, and either of you also has symptoms of depression or anxiety, this trial may offer free professional help.
IstanbulAges 24–65 - NCT07362407Enrolling by invitation
Cannabinoid treatment study for patients in Brazil
This study tracks how cannabis-based medicines work in real life. It looks at how people feel and function while using these treatments prescribed by their doctor.
Florianópolis, Santa CatarinaAges 18 years+
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Common questions
- Are there clinical trials for depression - major depressive disorder?
- Yes. Clin2 currently lists 204 recruiting depression - major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression - major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression - major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.