Clinical trials
Depression - Major Depressive Disorder clinical trials
Below are recruiting depression - major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 204 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07217860Enrolling by invitationPhase 3
Long-term safety study of azetukalner for bipolar depression
This study is looking at the long-term safety of azetukalner for people with bipolar I or II depression who have already completed a previous trial of this drug. It is an open-label study, meaning everyone will receive the active medication.
Little Rock, ArkansasAges 18–75 - NCT05568498RecruitingPhase 2
Probiotic trial for depression in Parkinson’s disease
This Phase 2 study tests whether taking probiotics can improve depression and mood symptoms in people with Parkinson’s disease. It’s meant for those with mild to moderate depression and stable Parkinson’s and mood treatments.
Vancouver, British ColumbiaAges 40–80 - NCT06560957Recruiting
Timed eating for bipolar depression study
This study tests if a timed eating schedule (eating within a set window each day) can help improve depression symptoms in people with bipolar disorder. The goal is to see if this eating pattern can stabilize mood and energy.
Ottawa, OntarioAges 18–55 - NCT06831435Recruiting
Digital therapy for depression study
This study tests if a digital cognitive behavioral therapy program can help treat depression in real-world settings. It is designed for people aged 14 to 60 who have moderate to severe depression symptoms.
Beijing, Beijing MunicipalityAges 14–60 - NCT07073521Recruiting
Cognitive therapy for adjusting to vision loss
This study tests new ways to help people adjust to vision loss using thinking and coping strategies. If you are an adult with vision loss and willing to share feedback, this may be a good fit.
Chicago, IllinoisAges 18 years+ - NCT05699525Recruiting
Personalized app for cognitive behavioral therapy for young adults
This trial tests a mobile app that delivers personalized cognitive behavioral therapy (a structured talk-therapy approach that helps change unhelpful thoughts and behaviors). It may help reduce symptoms of anxiety, depression, or bipolar disorder for people who fit the study’s timing and safety requirements.
New York, New YorkAges 18–25 - NCT05763537Recruiting
Study exploring how doulas support pregnancy mood changes
This study looks at how having a doula affects support and wellbeing for people experiencing pregnancy-related mood and anxiety changes. It may help you and others learn what kind of doula support is most helpful during pregnancy.
Missoula, MontanaAges 18 years+ - NCT06263738Recruiting
Cold and heat therapy for depression
This trial tests if carefully controlled cold or heat exposure can help lower symptoms of depression. It is open to people with or without depression to see how the body responds to changes in temperature.
Edwards, ColoradoAges 18–65 - NCT05837104RecruitingPhase 2
Magnesium and vitamin B6 for early bipolar depression
This Phase 2 trial tests whether magnesium plus vitamin B6 can reduce depressive symptoms in people who are newly diagnosed with bipolar I disorder. It also checks for safety over a short, 4-week treatment period.
Belmont, MassachusettsAges 18–50 - NCT06273527RecruitingPhase 2/Phase 3
Thinking skills training for mood and anxiety
This study tests whether a computerized training program can help people with mood, anxiety, or trauma-related disorders who struggle with repetitive negative thinking. If you are an outpatient and can have an MRI, this may be a good fit.
San Diego, CaliforniaAges 21–55 - NCT06768749Recruiting
Melatonin lotion for better sleep and mood
This trial tests whether using a scented melatonin lotion before bed can improve sleep and reduce anxiety or depression symptoms. It may be a good fit if you have mild sleep problems and some mood symptoms but are not currently taking medication for them.
Redlands, CaliforniaAges 18–21 - NCT06892847Recruiting
Brain stimulation for anxiety and depression in youth
This study tests if a non-invasive brain stimulation technique called TMS can help reduce symptoms of anxiety or depression in children and teens. It involves sessions where a magnetic field is used to gently stimulate parts of the brain, and is designed for young people aged 6 to 18 who have been diagnosed with these conditions.
Calgary, AlbertaAges 6–18 - NCT05797428Recruiting
Talk-based therapy to help teens cope with mood problems
This trial tests “logotherapy,” a type of counseling that helps people find meaning and purpose to cope with sadness or mood swings. It may help adolescents with mild to moderate-to-severe depression feel better and participate in structured therapy.
Kaohsiung City, Niaosong DistrictAges 15–24 - NCT06363981Recruiting
Brain stimulation for depression, sleep and memory problems
This study tests a non-invasive brain stimulation treatment (called rTMS) to help with depression, sleep problems, and memory or concentration issues. It's designed for people with moderate to severe depression who also have trouble sleeping and thinking clearly.
KrakowAges 18–65 - NCT06917339Recruiting
A study looking at past treatment records
This trial looks back at medical records in the TrakStar database to understand how treatments were given. It does not test a new drug, but helps researchers learn from past treatment experiences.
Malvern, PennsylvaniaAges 5–120 - NCT05567640Recruiting
Smart digital mental health support
This study tests a digital mental health program that uses smart technology to personalize your experience and keep you engaged. If you join, you may get a more tailored approach to improving your mental well-being.
Boston, MassachusettsAges 18 years+ - NCT06928428Enrolling by invitation
Online talk therapy for depression or anxiety
This study tests if a type of talk therapy called metacognitive therapy, delivered partly online, helps adults with depression or generalized anxiety. It aims to see if this blended approach works well in primary care.
Stockholm, Stockholm CountyAges 18 years+ - NCT06162624Recruiting
Workbook to help with anxiety and depression in prison
This study is testing a special workbook that helps people in prison manage tough emotions like anxiety and depression using a technique called ACT (Acceptance and Commitment Therapy). The workbook is designed to be used on your own, and the study wants to see if it can help you feel better.
Madison, WisconsinAges 18 years+ - NCT06424184Recruiting
Fast brain stimulation for addiction and depression
This study tests a quick, non-invasive brain stimulation method (rTMS) to help people who use stimulants like cocaine or methamphetamine and also feel depressed. The goal is to see if it can reduce cravings and improve mood.
Dallas, TexasAges 18–65 - NCT06891326Recruiting
Testing tACS for depression relief
This study tests if a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can safely treat depression. It uses mild electrical pulses on the scalp to help improve mood.
ShanghaiAges 18–65 - NCT06610552Recruiting
Powerly: Preventing depression and anxiety after childbirth
This trial tests a science-based smartphone program to help prevent postpartum depression and anxiety. It is designed for pregnant women who are between 24 and 32 weeks along and have an iPhone.
ZurichAges 18 years+ - NCT02443636Recruiting
Join a depression and mental health research registry in Atlantic Canada
This trial is a “registry,” meaning you can share your health information to help researchers study depression and other mental health needs in Atlantic Canada. Being part of the registry may help researchers understand patterns and improve future support and treatments.
Halifax, Nova ScotiaAges Any age - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT05754151Recruiting
Mobile therapy for anxiety and depression in adults 40+
This trial tests whether a phone or tablet version of cognitive behavioral therapy (CBT) can help people ages 40 and older with anxiety or depression. It may help you manage symptoms with skills you can use between sessions.
New York, New YorkAges 40 years+
Hear when a new Depression - Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for depression - major depressive disorder?
- Yes. Clin2 currently lists 204 recruiting depression - major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression - major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression - major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.