Clinical trials
Depression - Major Depressive Disorder clinical trials
Below are recruiting depression - major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 204 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05989451Recruiting
Talk therapy for depression and anxiety
This trial tests a type of talk therapy called dialectical behavior therapy (DBT) adapted to help people with emotional disorders like depression or anxiety. It aims to improve emotional regulation and reduce symptoms.
TaipeiAges 18–65 - NCT07637799Recruiting
Parent support group for teens with autism and anxiety or depression
This study tests whether a parent support group helps families manage anxiety or depression in teenagers who have autism. The group teaches parents skills to support their teen at home.
GothenburgAges 12 years+ - NCT07295652Recruiting
Understanding thinking problems in brain disorders
This study looks at how psychiatric and neurological conditions affect thinking and memory skills. By comparing patients with healthy volunteers, researchers hope to better understand these cognitive problems and find new ways to help.
ParisAges 18 years+ - NCT07159347Recruiting
Daily stress and app for depressed children
This study aims to understand what daily stressors look like in children with signs of depression. Your child would use a smartphone app and answer questions to help design a game-like tool that teaches emotion management skills.
München, BavariaAges 8–12 - NCT07654179Recruiting
Metformin for depression with obesity: a genetic study
This trial tests if adding metformin to antidepressants helps people who have both depression and obesity. It also looks at genetic factors that might affect treatment response.
Rawalpindi, Punjab ProvinceAges Any age - NCT06090422RecruitingPhase 1/Phase 2
Ketamine for depression and alcohol use disorder
This trial tests if ketamine can help people who have both depression and alcohol use disorder. You must be currently sober, have at least moderate depression, and be admitted to the hospital for addiction treatment.
TromsøAges 18–65 - NCT06706232RecruitingPhase 2
Psilocybin for Depression and Suicidal Thoughts in Bipolar II
This trial tests if two doses of psilocybin, given under medical supervision, are safe and acceptable for people with Bipolar II disorder who have mild to moderate depression and certain suicidal thoughts. The goal is to see if it may help improve mood and reduce suicidal thinking.
Houston, TexasAges 25–70 - NCT06630065Recruiting
Ketamine study for depression using brain scans
This trial uses brain scans to understand how ketamine affects negative emotions in people with depression. It may help explain why ketamine works and who benefits most.
Paris, ParisAges 18 years+ - NCT07364799Recruiting
Sound therapy for stress in detained teens
This trial tests a multi-sensory therapy called SoundHeal for teens in juvenile detention. It uses sound and vibration to help with stress, anxiety, depression, or substance use.
San Luis Obispo, CaliforniaAges 12–18 - NCT07363980Enrolling by invitation
Heart CT Study for Rheumatoid Arthritis Patients
This study uses a special heart CT scan to look for early signs of heart disease in people with rheumatoid arthritis. It may help find problems before symptoms start.
AarhusAges 50–75 - NCT07389473Recruiting
Studying eye movements in long-term psychiatric medication use (Gaize device)
This trial uses a special device (Gaize) to track how your eyes move while you take psychiatric medication. It aims to see how long-term medication affects eye patterns, which could help doctors better understand treatment responses.
Philadelphia, PennsylvaniaAges 18–65 - NCT06738953Recruiting
Preventing mental disorders with a self-efficacy course
This trial tests if a course designed to boost your belief in your own abilities can help prevent anxiety, mood, or substance use disorders. It is for young adults who currently feel less confident in handling challenges.
Potsdam, BrandenburgAges 18–30 - NCT07117058Recruiting
Anxiety and depression screening for young cancer survivors
This study tests a quick tool to identify anxiety or depression in children, teens, and young adults who have finished intensive cancer treatment and are now in remission. It aims to help doctors provide better mental health support.
CaenAges 7–25 - NCT07174947RecruitingPhase 2
Fluoxetine plus immunotherapy for advanced liver cancer with depression
This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help treat advanced liver or bile duct cancer in people who also have depression or anxiety. You must not have received any prior cancer treatment and be ready to start immunotherapy as your first therapy.
Wenzhou, ZhejiangAges 18–80 - NCT07078227Recruiting
Long-term depression follow-up study
This study follows up with people who took part in an earlier research project on depression and genetics. The goal is to see how depression changes over time.
LundAges 18 years+ - NCT04900064Recruiting
Self-help CBT added to primary care behavioral health
This trial studies whether adding a Swedish self-help version of “CBT” (a structured talking-therapy approach) improves care for adults getting behavioral health support in primary care. It may help people who want support for mental health without needing fully guided therapy sessions.
Varberg, Halland CountyAges 18 years+ - NCT07682064Recruiting
Group therapy for emotional disorders in adults
This trial tests a group therapy program for adults with emotional disorders like depression or anxiety. It is designed to help you manage difficult emotions and improve your well-being.
Logroño, La RiojaAges 18–65 - NCT05874362Recruiting
Study grief after violent loss and how time is perceived
This study looks at how people who recently lost a close family member to a violent death experience grief, including how they perceive time. It may help researchers understand these effects and better plan future support for bereaved people.
BronAges 18–65 - NCT06789250Recruiting
Online therapy for mental health and alcohol use issues
This trial tests an internet-based cognitive behavioral therapy program designed for people who struggle with both mental health symptoms (like depression or anxiety) and problematic alcohol use. The goal is to see if this approach can help improve both issues at the same time, conveniently from home.
LinköpingAges 18 years+ - NCT05117255Recruiting
Online therapy study for anxiety in residential alcohol treatment
This study tests an internet-based, interactive version of cognitive behavioral therapy (CBT) for anxiety symptoms. It’s designed for people getting mainly alcohol-focused treatment in a residential program, to see if the online approach works and is feasible for you.
Minneapolis, MinnesotaAges 18–65 - NCT05183503Enrolling by invitation
Study of pain, stress, anxiety, and depression in jaw disorder
This study looks at how chronic jaw pain from temporomandibular disorder (TMD) relates to stress, anxiety, and depression in adults. Your results may help researchers better understand what affects symptoms and how people respond to care.
WroclawAges 18–80 - NCT05480826Recruiting
Family genetic study for mood, thinking, and autism conditions
This study looks at genetic changes found in people with conditions like bipolar disorder, schizophrenia, depression, or autism, and compares how those genetic differences may function. It may help researchers understand the causes of these conditions using information from patients and their relatives.
CréteilAges 18 years+ - NCT06038721Recruiting
Unified Protocol for kids with emotional concerns
This trial tests a program called Unified Protocol for children ages 7–17 who have emotional difficulties like anxiety, depression, trauma, or obsessive-compulsive symptoms. It aims to help kids and their parents learn skills to manage these feelings together.
Coral Gables, FloridaAges 7–17 - NCT07018245RecruitingPhase 2
TJ0113 Capsule for depression: a phase 2 study
This trial tests an investigational medication called TJ0113 for people with moderate to severe depression. It aims to see if the drug can safely improve depression symptoms when other treatments are stopped during the study.
Hangzhou, ZhejiangAges 18–65
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Common questions
- Are there clinical trials for depression - major depressive disorder?
- Yes. Clin2 currently lists 204 recruiting depression - major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression - major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression - major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.