Clinical trials
Depression - Major Depressive Disorder clinical trials
Below are recruiting depression - major depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 193 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06456307Recruiting
Stepped care for mood and anxiety during pregnancy
This study tests a step-by-step approach to help pregnant women who are feeling anxious or down. If you are at least 28 weeks pregnant and feeling stressed, worried, or sad, the study will offer you support and check on how you are doing.
NairobiAges 14 years+ - NCT04080778Recruiting
Magnetic seizure treatment for severe bipolar or hard-to-treat depression
This trial studies whether a seizure-like therapy using magnet stimulation can quickly reduce severe depressive symptoms in people with bipolar depression or treatment-resistant depression. It may help when depression is intense and hasn’t improved enough with at least two antidepressant medicines.
Houston, TexasAges 22–85 - NCT04610697Recruiting
Cognitive training for people in forensic mental health care
This trial studies whether a structured “cognitive remediation” program (training thinking skills) can help people receiving care on a forensic treatment unit. It may benefit those who want support improving attention, memory, or problem-solving as part of their treatment.
Ottawa, OntarioAges 18–55 - NCT05009433Recruiting
Exercise plans in pregnancy and afterward for mom and baby health
This study compares two types of exercise—short, intense intervals versus moderate steady activity—during pregnancy and looks at effects on mothers and children. It also checks how participants do on health, fitness, and well-being tests before, during, and after pregnancy.
Gdansk, Pomeranian VoivodeshipAges 18–45 - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT05868135Recruiting
Online guided therapy for depression and anxiety
This trial tests an internet-based (online) guided psychological program, called e-Meistring, for people with moderate depression plus panic disorder and social anxiety. It aims to see whether the program improves symptoms and is also worth the cost.
BergenAges 18 years+ - NCT05541406Recruiting
School support program for LGBTQ high school students
This trial is testing a program designed to make high schools more supportive for LGBTQ students. It aims to see if the program improves the school experience and well-being of LGBTQ youth.
El Monte, CaliforniaAges 12–20 - NCT06278532Recruiting
Validating psychosis assessment tools in Lithuanian
This trial tests whether three psychiatric questionnaires work well for people with schizophrenia or related disorders. If you are between 18 and 65 and have one of these diagnoses, joining may help improve care for others like you.
KaunasAges 18–65 - NCT07458698Recruiting
A digital program to prevent anxiety during pregnancy
This study tests a mobile app called Reaching Calm that may help prevent anxiety disorders in pregnant people. It is for those who are already receiving prenatal care and have mild to moderate anxiety symptoms.
Leominster, MassachusettsAges 18 years+ - NCT06899490Recruiting
Acupuncture study for anxiety with tongue analysis
This trial uses machine learning to analyze tongue color and anxiety scores in people getting acupuncture for anxiety. It aims to see if tongue color can help predict treatment response.
NarbonneAges 18 years+ - NCT06538246Recruiting
Coping skills training for heart and lung failure survivors
This study tests a coping skills training program to help people who recently survived a serious heart or lung problem feel less anxious, depressed, or stressed. If you were in the ICU and now feel distressed at home, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT05563805Recruiting
Virtual reality adventure training for movement and fitness
This study uses a virtual reality “adventure” game that gets you moving to train exercise skills and coordination. It’s designed for U.S. military veterans who can walk on their own and don’t have certain vision, balance, or medical limits.
Arlington, TexasAges 18–45 - NCT07022925Recruiting
Wearable device for tracking hot flushes in perimenopause
This study will test if a wearable device can accurately track symptoms like hot flushes and night sweats in women going through perimenopause. If you are between 35 and 55 and experiencing these symptoms, your participation could help improve future symptom monitoring.
London, OntarioAges 35–55 - NCT05726721Recruiting
Study of treatment targets for binge eating disorder
This trial studies how binge eating disorder behaves during treatment and compares patterns over time. It may help by improving future treatment approaches for people with binge eating disorder.
Aarhus, Central JutlandAges 18 years+ - NCT06270121Recruiting
Mobile health app for healthy aging at home
This study is testing a mobile health app designed to help seniors live independently at home. If you join, you will use the app and answer surveys to see if it supports healthy aging.
SeoulAges 65 years+ - NCT07083037Recruiting
Parent program to help kids' attention and behavior
This trial tests a program for mothers who have mild to moderate depression and whose child has attention or behavior problems. The program aims to improve both the mother's well-being and the child's behavior.
Winnipeg, ManitobaAges 18 years+ - NCT06885138Enrolling by invitation
Testing brain stimulation for depression in Parkinson's disease
This trial tests if a gentle brain stimulation technique called tDCS can improve depression symptoms in people with Parkinson's disease. You'll receive either real or placebo stimulation over several sessions to see if it helps your mood.
MilanAges 35–75 - NCT06521398Recruiting
Postpartum Care for Preterm NICU Babies
This study focuses on helping new mothers of preterm babies (born before 34 weeks) who are getting care in the NICU at HUP. It tests a program to support your transition home after giving birth, so you and your baby can thrive.
Philadelphia, PennsylvaniaAges 16 years+ - NCT05322343Recruiting
Study biobank and brain health in people age 55–80
This study collects blood samples to build a biobank and learn how brain health changes with age. Some participants may also do an MRI scan to better understand brain changes and immune response.
Bordeaux, BordeauxAges 55–80 - NCT04201600Recruiting
Study how blood sugar swings affect thinking in prediabetes
This study looks at how “blood sugar variability” (how much glucose levels bounce around) may affect thinking and memory in people with prediabetes. You may be eligible if you’re older and don’t already have diabetes or conditions that can strongly affect the brain or blood vessels.
Baltimore, MarylandAges 50 years+ - NCT05671185Recruiting
Brain stimulation for schizophrenia symptoms and depression
This study tests repeated brain stimulation (rTMS) to see if it can improve symptoms of schizophrenia and related depression, and measure body/brain changes. You may be considered if you have schizophrenia or schizoaffective disorder with enough depressive symptoms, and if recent treatments and medical safety factors fit the rules.
Douliu, YunlinAges 20 years+ - NCT07217197Enrolling by invitation
A monitor to detect breathing problems after surgery
This trial tests a new respiratory monitoring system to see if it can detect and predict opioid-induced respiratory depression (OIRD) — when pain medicines slow your breathing too much — in patients recovering from surgery. The monitor uses a face mask, nasal cannula, and small sensors to track breathing continuously, so that doctors can step in early if there is a problem.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+
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Common questions
- Are there clinical trials for depression - major depressive disorder?
- Yes. Clin2 currently lists 193 recruiting depression - major depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression - major depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression - major depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.