Clinical trials
Depression Symptoms clinical trials
Below are recruiting depression symptoms clinical trials, each written for real people, not researchers. We’re tracking 194 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06633263Enrolling by invitation
Combined therapy for depression and insomnia
This trial tests a combination of two behavioral therapies to improve both depression symptoms and sleep problems. It may help you if you have moderate depression and insomnia and can participate in French-language sessions.
LiègeAges 18–67 - NCT06975280Recruiting
PTSD therapy for unaccompanied refugee teens in Greece
This study tests a talking therapy (Trauma-Focused Cognitive Behavioral Therapy) to help unaccompanied refugee minors aged 15-18 who have PTSD or stress symptoms from trauma. It aims to see if the therapy reduces distress and helps them feel better.
AthensAges 15–18 - NCT06628830Enrolling by invitation
App for depression and anxiety in college students
This trial tests if a mobile phone app can help college students with mild to moderate depression and anxiety. You may be eligible if you are a student with moderate symptoms and not currently in treatment.
Santiago, Santiago MetropolitanAges 18–29 - NCT07413705Recruiting
Devices for depression and sexual health in menopause
This study tests two devices (BTL-699-2 and HPM-6000UF) to see if they can improve depression symptoms and sexual function in women going through menopause or perimenopause. It may help with mood and intimacy during this life stage.
Winter Garden, FloridaAges 40 years+ - NCT07022184Recruiting
Lifestyle app for depression with GP support
This trial tests a lifestyle app to help people with depression who are under a GP's care. It looks at whether using the app alongside your usual treatment can improve your mood.
Nijmegen, GelderlandAges 18 years+ - NCT07687940Recruiting
Baduanjin exercise and green tea for mood in older adults
This study tests if doing gentle Baduanjin exercises and drinking green tea together can help improve mood and quality of life in older adults. It also looks at how this program affects gut health.
Kwun TongAges 65–84 - NCT07413692Recruiting
Device therapy for depression and urinary incontinence after childbirth
This study tests two devices to help with depressive symptoms and urinary incontinence in women who gave birth 2–60 months ago. It aims to see if the treatments can improve how you feel and bladder control without using medication.
Garfield Heights, OhioAges 22–60 - NCT05567640Recruiting
Smart digital mental health support
This study tests a digital mental health program that uses smart technology to personalize your experience and keep you engaged. If you join, you may get a more tailored approach to improving your mental well-being.
Boston, MassachusettsAges 18 years+ - NCT04123314RecruitingEarly Phase 1
Psilocybin study for depression in mild memory or early Alzheimer’s
This early-phase study tests whether psilocybin (a psychedelic substance) can help with depression in people who have mild memory problems or early Alzheimer’s. The trial also closely monitors safety, thinking changes, mood, and blood pressure before and after dosing.
Baltimore, MarylandAges 18–85 - NCT06776887Recruiting
Virtual reality exercises for burn recovery on legs
This trial tests whether virtual reality exercises can help people with leg burns improve balance and reduce depression and anxiety. It is for people who had a large thermal burn on their lower body at least 3 months ago.
GizaAges 35–55 - NCT07284446Recruiting
Depression, memory, and outcomes in heart failure patients
This study looks at how depression and memory problems affect recovery in people hospitalized with worsening chronic heart failure. It aims to find better ways to support patients during their hospital stay.
KaunasAges 18–85 - NCT07222306Enrolling by invitation
Cannabis, brain inflammation, and suicidal thoughts brain imaging study
This study uses brain scans to see how cannabis affects inflammation and suicidal thoughts. You may join if you're already in a related study and can safely undergo MRI and PET scans.
Detroit, MichiganAges 19–69 - NCT07064551Recruiting
Combining medical and community support for depression
This study tests a new way of combining medical care with community support for middle-aged and older adults who have depression and are waiting for mental health services. The goal is to see if this team approach can help improve mood and well-being while you wait.
Hong KongAges 45 years+ - NCT07717385Recruiting
90-day trial of a probiotic for stress and sleep
This study tests whether a daily probiotic capsule called Neuralli Mood can help adults who feel stressed, have trouble sleeping, or experience low mood. It lasts 90 days and involves taking two capsules each day and filling out online surveys.
New York, New YorkAges 18 years+ - NCT05800522Recruiting
Supportive parenting program for kids with behavior and mood struggles
This trial tests whether a supportive parenting program can help children who are showing higher-than-usual symptoms like anxiety, depression, anger, or behavior problems. If you’re not already in certain specialized mental health programs, your child may be able to join and get structured support for coping.
OsloAges 4–12 - NCT06574035Recruiting
Exercise and counseling for Black men with diabetes
This study tests whether a program combining physical activity with cognitive behavioral therapy (a type of talk therapy) helps African American men manage type 2 diabetes better. You would attend weekly exercise and counseling sessions for several months.
Ann Arbor, MichiganAges 18 years+ - NCT06745934Recruiting
Strengthening health and insight for new teachers
This study aims to help new teachers by checking in on their health and well-being. If you are a student in Block 3, you may be invited to take part.
Tuscaloosa, AlabamaAges 18 years+ - NCT06773338Recruiting
Can playing Tetris improve mental health for migrants?
This study tests if playing the game Tetris can help reduce stress and improve mood for Arabic-speaking immigrants who have applied for asylum. You would play Tetris a few times and report how you feel.
The Hague, NLAges 18 years+ - NCT06921512Recruiting
Chinese therapeutic exercise for anxiety and depression
This study tests whether a traditional Chinese mind-body exercise (Daoyin) can help people with mild to moderate anxiety and depression. It also looks at how the exercise might affect your body and mind.
ShanghaiAges 18–65 - NCT06995807Recruiting
EL-SHIN therapy for depression and stress
This trial tests a new therapy called EL-SHIN for people with moderate depression, anxiety, and stress. It may help if you are a non-Muslim who believes in creationism.
Kuala LumpurAges 18 years+ - NCT07007234Recruiting
Sedentary behavior and depression study
This study looks at how sitting or being inactive (sedentary behavior) affects depressive symptoms. If you have mild to severe depression, you may be able to join and help find out if moving more can improve your mood.
São Paulo, SOAges 18 years+ - NCT06415838Recruiting
Behavioral activation for depression in older adults
This trial tests a simple, practical therapy called behavioral activation to help older adults with depression feel better. It's done in your local community, not in a hospital.
Eskilstuna, SörmlandAges 65 years+ - NCT05973461Recruiting
Exercise and virtual reality study for depression
This study looks at whether doing regular exercise and using virtual reality can help with depression symptoms, compared to not doing them. You may be included even if you do not currently have depression symptoms, as long as you meet the safety and participation requirements.
Arlington, TexasAges 18–65 - NCT05426967Recruiting
Brain stimulation for depression after mild traumatic brain injury
This trial studies a noninvasive brain treatment (rTMS) to reduce depression symptoms in people with past mild traumatic brain injury from military service. It may help by changing brain activity, while also requiring stable mental health care and regular follow-up.
Palo Alto, CaliforniaAges 18–55
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Common questions
- Are there clinical trials for depression symptoms?
- Yes. Clin2 currently lists 194 recruiting depression symptoms studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression symptoms trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression symptoms trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.