Clinical trials · San Diego, CA
Depression clinical trials in San Diego
We’re tracking 47 recruiting depression studies with a site in or near San Diego — including Phase 2, Phase 2/Phase 3, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near San Diego
- NCT06922110Enrolling by invitationPhase 3
Long-term study of azetukalner for depression
This study is for people who already completed a previous trial of azetukalner for major depressive disorder. It tests the long-term safety and effects of continuing the medication.
San Diego, CaliforniaAges 18 years+ - NCT07217223Recruiting
Home-based brain stimulation for treatment-resistant depression
This study tests whether a gentle brain stimulation technique called tDCS can help people with depression that hasn't improved with medication. It can be done at home using a special headset and an internet connection.
San Diego, CaliforniaAges 18–85 - NCT06162741Recruiting
Brief mindfulness training for Veterans in primary care
This study tests whether brief mindfulness training offered in VA primary care can help Veterans with symptoms of PTSD, depression, or anxiety. It aims to see if this approach works well in everyday clinic settings.
San Diego, CaliforniaAges 18 years+ - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
San Diego, CaliforniaAges 18 years+ - NCT06938841Recruiting
Maintenance rTMS for depression
This study tests whether ongoing rTMS treatments can help people who already improved after an initial round of rTMS for depression. It aims to keep the benefits going and prevent relapse.
San Diego, CaliforniaAges 18–80 - NCT07484217RecruitingPhase 3
Testing solriamfetol for depression with daytime sleepiness
This study tests if the drug solriamfetol can help people with major depression who also feel very tired during the day. It aims to improve both mood and daytime sleepiness.
San Diego, CaliforniaAges 18–65 - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
San Diego, CaliforniaAges 18–75 - NCT07420205RecruitingPhase 2
Sleep health study for U.S. Marines
This study looks at the sleep health of active-duty U.S. Marines. If you join, researchers will check your sleep patterns and may offer ways to improve your rest.
San Diego, CaliforniaAges 18 years+ - NCT07512284RecruitingPhase 2
Mindfulness and Brain Stimulation for Treatment-Resistant Depression
This study combines mindfulness practice with transcranial magnetic stimulation (TMS)—a non-invasive brain stimulation technique—to help people with depression that hasn't improved with antidepressant medications. The goal is to see if adding mindfulness to TMS improves how well the treatment works.
San Diego, CaliforniaAges 18–65 - NCT07792837Recruiting
Online intuitive eating program for pregnant women with obesity
This study tests an online program that helps pregnant women with obesity learn to eat intuitively, which means listening to their body's hunger and fullness signals instead of dieting. The goal is to support their well-being during pregnancy.
San Diego, CaliforniaAges 18 years+ - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
San Diego, CaliforniaAges 18–74 - NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
San Diego, CaliforniaAges 18–65 - NCT05176392Recruiting
Stimulation treatment plus therapy for post-injury headaches
This study tests whether a noninvasive brain stimulation treatment combined with therapy can reduce long-lasting headaches after a mild brain injury. You might be a good candidate if your headaches started after the injury and have continued for months.
San Diego, CaliforniaAges 18–65 - NCT05377177Recruiting
Brain stimulation type test for suicidal thoughts in depression
This study tests whether stimulating the brain on both sides at once versus one side can reduce suicidal thoughts in people with treatment-resistant depression. It also looks at brain “inhibition” signals to help predict who benefits.
San Diego, CaliforniaAges 18–70 - NCT06269146RecruitingPhase 2
Pramipexole to improve social connections
This study tests if a medication called pramipexole can help people with anxiety or depression who also find it difficult to connect socially. It looks at whether the drug can improve your motivation for social interactions and help you feel more connected.
San Diego, CaliforniaAges 18–50 - NCT06273527RecruitingPhase 2/Phase 3
Thinking skills training for mood and anxiety
This study tests whether a computerized training program can help people with mood, anxiety, or trauma-related disorders who struggle with repetitive negative thinking. If you are an outpatient and can have an MRI, this may be a good fit.
San Diego, CaliforniaAges 21–55 - NCT06678880Recruiting
Sleep and light for mood during menopause
This study tests a program that combines better sleep habits with timed bright light exposure to help improve mood in women going through menopause. It may help reduce the sad or hopeless feelings that often come with this transition.
San Diego, CaliforniaAges 45–75 - NCT07105111RecruitingPhase 4
Valbenazine for tardive dyskinesia after other treatment
This study tests if valbenazine helps adults with tardive dyskinesia whose symptoms continue even after taking or stopping another similar medication. Tardive dyskinesia involves uncontrollable movements from long-term use of certain mental health drugs.
San Diego, CaliforniaAges 18 years+ - NCT07621237RecruitingPhase 2
TNX-102 SL for Major Depressive Disorder
This study tests whether a new medication called TNX-102 SL can reduce depression symptoms better than a placebo (inactive pill). You'll take the medication daily and have regular check-ins to see how you're doing.
San Diego, CaliforniaAges 18 years+ - NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
San Diego, CaliforniaAges 18–75 - NCT06966401RecruitingPhase 3
Long-term safety study of a new depression treatment
This study tests a new oral medication (NBI-1065845) added to your current antidepressant to see if it's safe and tolerable over a long period for people with depression that hasn't fully responded to treatment.
San Diego, CaliforniaAges 18 years+ - NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
San Diego, CaliforniaAges 18 years+ - NCT06898879Recruiting
Working together to improve mental health care for veterans
This study is for veterans getting mental health support through VA programs. It tests a way to improve teamwork between veterans and their care teams to make the care better.
San Diego, CaliforniaAges 18 years+ - NCT06372964RecruitingPhase 3
Lumateperone for pediatric bipolar depression
This study tests a new medication called lumateperone for treating depression in children and teens with bipolar disorder. It aims to see if this drug can help improve mood and daily functioning.
San Diego, CaliforniaAges 10–17
Hear when a new Depression trial opens near San Diego, CA
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Depression trials in other cities
Where these studies are running near San Diego
Institutions with a site for the recruiting depression studies listed above.
- University of California San Diego · 6 studies
- Neurocrine Clinical Site · 4 studies
- VA San Diego Healthcare System · 3 studies
- Artemis Institute for Clinical Research · 2 studies
- Clinical Research Site · 2 studies
- Research Site · 2 studies
- San Diego State University · 2 studies
- UCSD Interventional Psychiatry · 2 studies
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in California.
Common questions
- Are there depression clinical trials near San Diego?
- Yes. We're currently tracking 47 recruiting depression studies with a site near San Diego, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near San Diego?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in San Diego to take part?
- Not necessarily. These studies have a site near San Diego, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near San Diego regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.