Clinical trials
Depressive Symptoms clinical trials
Below are recruiting depressive symptoms clinical trials, each written for real people, not researchers. We’re tracking 181 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06888284Enrolling by invitation
Tuijing therapy for depression and heart rate
This trial tests whether Tuijing therapy, a non-invasive treatment, can improve heart rate variability and reduce depression symptoms in people who have been feeling depressed for over three months. It may be an option if you haven't used other treatments recently.
Hong KongAges 18–60 - NCT04084795Recruiting
EMDR plus brain stimulation for fibromyalgia pain and stress
This trial tests whether combining EMDR therapy with a mild form of brain stimulation can reduce fibromyalgia symptoms, including pain and trauma-related emotional distress. It may help people whose fibromyalgia is closely linked to past trauma and current anxiety or depression.
Barcelona, CataloniaAges 18–70 - NCT06722287Recruiting
Phone support for family caregivers in Thailand
This study tests a mobile program to support the mental health of family caregivers in Thailand. You participate from home using your phone.
BangkokAges 18–80 - NCT05322343Recruiting
Study biobank and brain health in people age 55–80
This study collects blood samples to build a biobank and learn how brain health changes with age. Some participants may also do an MRI scan to better understand brain changes and immune response.
Bordeaux, BordeauxAges 55–80 - NCT06586619Recruiting
Tai chi and qigong for older adults with HIV
This study tests whether a remotely taught tai chi and qigong program can improve mood and well-being in people aged 50–75 who are living with HIV. You can join from home using a smartphone.
Miami, FloridaAges 50–75 - NCT06215235Recruiting
Bright light therapy for depression in intellectual disability
This trial studies how bright light therapy (using a special lamp) is being used to help people with intellectual disabilities who have depression. It involves staff, family members, and patients to see how the therapy works in real life.
RotterdamAges 18 years+ - NCT06085313Recruiting
Web-based program for cancer pain in Asian women
This trial tests a web-based program to help women of Chinese, Korean, or Japanese heritage manage breast cancer pain and depressive symptoms. If you've had breast cancer, have had pain in the past week, and feel some depression, this program could help you cope better.
Austin, TexasAges 18 years+ - NCT05897021Recruiting
Writing exercises to ease stress for sexual minority veterans
This study tests whether guided “expressive writing” helps reduce distress linked to sexuality-based stress. It targets veterans who have meaningful anxiety or depression symptoms and ongoing stress related to their sexual identity.
Boston, MassachusettsAges 18 years+ - NCT05802004Recruiting
Sound stimulation to improve sleep and emotions in young adults
This study tests whether gentle sound stimulation during sleep can improve sleep and how you think and feel in daily life when you have anxiety or depression symptoms. You’ll also do sleep testing in a lab and complete questionnaires to measure changes.
Pittsburgh, PennsylvaniaAges 18–25 - NCT05752448Recruiting
Care plan support for women after ovarian cancer treatment
This trial looks at survivorship care—how to help women after ovarian cancer treatment. It may improve follow-up planning and support during the first months after treatment ends.
Dallas, TexasAges 18 years+ - NCT05323864Recruiting
Altitude exposure study for anxiety and low mood
This trial looks at what happens to people with anxiety and depressive symptoms after going to high altitude with low oxygen. It may help researchers understand whether altitude affects these symptoms and how it might be managed.
Innsbruck, TyrolAges 18–65 - NCT05447689Recruiting
Group mind-body skills for anxious graduate students
This trial offers a weekly group program teaching mind-body skills to help reduce anxiety. It’s for graduate students who screen as having moderate or higher anxiety and can attend meetings regularly.
White Plains, New YorkAges 18 years+ - NCT05369429Recruiting
Stress and mood support program for adults with cancer
This trial tests a new online “wellbeing guide” to help manage stress and improve quality of life. It focuses on adults with cancer who also have higher-than-usual depressive symptoms.
Chicago, IllinoisAges 18 years+ - NCT05219955Recruiting
Study of caregiver stress and sleep in older adults
This study looks at how caregiver stress affects sleep problems—especially trouble getting going in the morning. If you are a caregiver for someone with dementia and have specific morning sleep/energy difficulties, you may be able to join and help researchers better understand what helps.
Pittsburgh, PennsylvaniaAges 55 years+ - NCT03794531Recruiting
Study of health, stress, and lifestyle changes in Puerto Rico
This study looks at how people’s health, day-to-day stress, and living conditions in Puerto Rico change over time. You might help researchers understand what trends are happening and what could be improved.
San JuanAges 30–75 - NCT06384209Recruiting
Friendship Bench Plus for Depression
This study tests whether a structured talk therapy program called the Friendship Bench can help adults with moderate to severe depression. You will have conversations with trained lay counselors who guide you through problem-solving techniques.
HarareAges 18 years+ - NCT05925322Recruiting
Social reward therapy for depression-related suicidal thoughts
This study looks at whether “social reward” psychotherapy can change brain activity and reduce suicidal thoughts in adults ages 50–80 who also have major depression. You may be offered psychotherapy along with brain scans to see how your brain responds over time.
New York, New YorkAges 50–80 - NCT07865052Recruiting
Psychological support before complex stomach or intestinal surgery
This study tests whether a psychological program before major abdominal surgery can help reduce distress and improve recovery. Participants will receive extra mental health support to prepare for their operation.
Chicago, IllinoisAges 18 years+ - NCT04478305RecruitingPhase 1
Duavive trial for mood and anxiety in midlife women
This Phase 1 study tests Duavive’s effects on mood and anxiety symptoms in women going through perimenopause or early menopause. It may help clarify whether this treatment can reduce depression and/or anxiety symptoms in midlife.
Hamilton, OntarioAges 45–60 - NCT06864156Recruiting
Molecules and vitamin levels in long COVID with brain fog
This study looks at certain molecules (called microRNAs) and vitamin B12 levels in people who have ongoing brain-related symptoms like depression, anxiety, or fatigue after a COVID-19 infection. It may help understand why some people have long-lasting symptoms and could lead to better treatments.
Mexico City, Mexico CityAges 18–65 - NCT04935619Recruiting
Testing cannabis abstinence effects in depression symptoms
This study looks at how stopping cannabis for a period of time may affect depression symptoms and thinking/memory. You might benefit by getting close monitoring of mood and cognition while researchers compare changes during cannabis abstinence.
Toronto, OntarioAges 18–55 - NCT05585164Recruiting
Therapy program for postpartum depression up to one year
This trial tests a structured talk-therapy program for postpartum depression in the first year after having a baby. It may help by reducing depressive symptoms and improving day-to-day functioning.
New York, New YorkAges Any age - NCT07212075Recruiting
Digital twin study for mental health in diabetes
This study uses digital twins—a virtual model of your health—to track how your mental health changes with diabetes. It aims to find patterns that could help personalize mental health care.
Bad Mergentheim, Baden-WurttembergAges 18–80 - NCT07871916Recruiting
Mindfulness app for parents going through divorce or separation
This study tests a mindfulness app designed to help parents manage stress during divorce or separation. It may help you feel calmer and more focused as you navigate this challenging time.
Stamford, ConnecticutAges 18 years+
Hear when a new Depressive Symptoms trial opens
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Common questions
- Are there clinical trials for depressive symptoms?
- Yes. Clin2 currently lists 181 recruiting depressive symptoms studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive symptoms trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive symptoms trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.