Clinical trials
Depressive Disorder clinical trials
Below are recruiting depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 689 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Bryant, ArkansasAges 18–74 - NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Birmingham, AlabamaAges 12–17 - NCT06793397RecruitingPhase 3
Study of an experimental psychedelic-like drug for depression (CYB003)
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Birmingham, AlabamaAges 18–85 - NCT07783633Enrolling by invitation
Digital tools for mood disorders study
This study looks at whether using digital tools, like apps or online programs, can help people with mood disorders like depression or bipolar disorder. It aims to find markers that show who might benefit most from these tools.
Toronto, OntarioAges 16 years+ - NCT07480525Recruiting
Escitalopram for first-time depression
This trial tests whether escitalopram, a common antidepressant, helps people who are experiencing their first episode of depression and have never taken medication for it. It also looks at how the drug works in the brain.
Beijing, Beijing MunicipalityAges 18–65 - NCT07161700Enrolling by invitationPhase 2
Long-term safety study of SPT-300 for major depression
This study is for people who finished the earlier BUOY-1 study of SPT-300 and want to continue treatment. It tests the long-term safety and tolerability of SPT-300 for major depressive disorder, with or without anxious distress.
Chino, CaliforniaAges 18–66 - NCT07065240RecruitingPhase 2
Study of SPT-300 for major depression with or without anxiety
This trial tests an experimental oral medication, SPT-300, for people with major depressive disorder, even if they also have mild anxiety. The goal is to see if it helps improve mood safely.
Chino, CaliforniaAges 18–65 - NCT07412756RecruitingPhase 3
Brenipatide for major depressive disorder
This trial tests a new medication, Brenipatide, to see if it helps people with major depression who are already on a stable treatment. You would need to inject the study drug yourself and complete questionnaires.
Moorpark, CaliforniaAges 18–75 - NCT07474974Recruiting
Can Eye Cells Predict TMS Success for Depression?
This study tests whether a specific type of eye cell can predict how well transcranial magnetic stimulation (TMS) works for treating depression. TMS is a non-invasive brain stimulation method that may help people with depression that hasn't responded to other treatments.
Porto, Porto DistrictAges 18–65 - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Birmingham, AlabamaAges 18–65 - NCT06902298RecruitingPhase 1/Phase 2
Ultrasound brain stimulation for depression
This trial tests a new, non-invasive ultrasound treatment for people with depression who haven't gotten enough relief from at least two prior treatments. It uses sound waves to gently stimulate areas of the brain linked to mood.
Salt Lake City, UtahAges 18–65 - NCT07082998Recruiting
Heated yoga vs. sauna for depression
This study compares heated yoga with sauna sessions to see which helps reduce depression. You'll also use a mindfulness app. Both treatments are meant to boost mood and well-being.
Boston, MassachusettsAges 18–65 - NCT06801925Enrolling by invitation
Voice Chatbot for Depression Screening
This trial tests a voice chatbot that uses artificial intelligence to screen for depression. It aims to see if the chatbot is effective and easy to use.
LondonAges 18–65 - NCT07748091Recruiting
Brain wave and inflammation markers in shock therapy for depression
This study looks at brain wave patterns and markers of inflammation in people with depression that hasn't improved with other treatments and who are receiving electroconvulsive therapy (ECT, also known as shock therapy). The goal is to understand how these markers might relate to how well ECT works.
Istanbul, BakırköyAges 18–60 - NCT07740694Recruiting
ECT study for older adults with depression
This study looks at how ECT affects brain activity and inflammation in older adults with depression. It may help researchers understand why ECT works and improve treatment.
Istanbul, BakırköyAges 55 years+ - NCT05828056Recruiting
Predicting mood episodes in bipolar disorder with a smartwatch
This study uses a smartwatch and smartphone to track daily patterns and predict when manic or depressive episodes might happen in people with bipolar disorder. It aims to help patients and doctors better manage the condition.
TaipeiAges 20–60 - NCT05671419Recruiting
Mindful self-compassion training for anxiety and depression
This study tests whether a structured “mindful self-compassion” program can reduce symptoms of anxiety disorders or depression. It’s meant to help by improving how you relate to yourself during difficult thoughts and feelings.
Washington D.C., District of ColumbiaAges 18–75 - NCT07569198RecruitingPhase 2
Ketamine plus therapy for depression with suicidal thoughts
This study tests whether ketamine (a medication) combined with a specific type of therapy called DBT can help people with treatment-resistant depression and borderline personality disorder who are having thoughts of suicide. You would receive ketamine infusions alongside structured therapy sessions over 6 months.
Toronto, OntarioAges 18–70 - NCT07703722RecruitingPhase 3
Psilocybin and therapy for depression with trauma
This trial tests psilocybin (a compound from certain mushrooms) combined with a structured therapy to see if it helps people with depression linked to trauma. It focuses on how the treatment affects the connection between the gut and brain.
Islamabad, CapitalAges 18–60 - NCT04159662Recruiting
Brain scans to study thinking in schizophrenia and depression
This study uses brain imaging to better understand how thinking works in people with schizophrenia or major depression. Your results may help researchers learn what brain patterns match different thinking and symptoms.
Ottawa, OntarioAges 18–60 - NCT04480918Recruiting
Registry for people with depression or bipolar to receive psychiatry care
This is a patient registry that enrolls people being evaluated for treatment options from an Interventional Psychiatry Service. It helps track patients with depression, bipolar disorder, or treatment-resistant OCD who are suitable for these psychiatry treatments.
Iowa City, IowaAges 18–99 - NCT07562191RecruitingPhase 2
Inhaled DMT for major depression
This trial tests if inhaling DMT can help treat moderate to severe major depression. You may qualify if your depression has lasted at least two weeks and you have not changed medications recently.
Fortaleza, CearáAges 18 years+ - NCT04984512RecruitingPhase 2/Phase 3
Testing mitizodone tablets for major depression symptoms
This trial studies whether mitizodone phosphate tablets can improve symptoms of major depressive disorder (MDD). It also checks the treatment’s safety, including mood and physical health effects.
Dongguan, GuangdongAges 18–65 - NCT05543083Recruiting
Therapy plus exercise for teens at risk of type 2 diabetes
This trial tests whether a combination of coaching (cognitive-behavioral therapy) and exercise can improve mood and help teens who are at higher risk for type 2 diabetes. It may be especially helpful if you’re dealing with depression symptoms and a family history of type 2 diabetes.
Aurora, ColoradoAges 12–17
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Depressive Disorder trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for depressive disorder?
- Yes. Clin2 currently lists 689 recruiting depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.