Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,048 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01247597Recruiting
Study of DICER1-related tumor history in families
This study follows people affected by DICER1-related tumors (and sometimes family members) to better understand how these conditions develop over time. It may help families by improving knowledge and guiding genetic counseling and future care.
Bethesda, MarylandAges 1 month–99 years - NCT00026884Recruiting
Blood and tissue sample collection for cancer research
This study collects blood and tissue samples from people with cancer or suspected cancer, or from their blood relatives. Researchers use these samples to better understand cancer and develop new treatments.
Bethesda, MarylandAges 2 years+ - NCT00033137Recruiting
Genetic study of Birt-Hogg-Dubé syndrome and kidney cancer risk
This research study examines the genes behind Birt-Hogg-Dubé (BHD) syndrome, a condition that increases kidney cancer risk. Researchers want to understand who inherits this condition and how to better identify and help people at risk.
Bethesda, MarylandAges 2 years+ - NCT00977977RecruitingPhase 2
Rituximab plus cyclosporine for membranous kidney disease
This trial tests whether rituximab (an immune-targeting medicine) plus cyclosporine (another immune medicine) can better control protein leakage in the urine for people with idiopathic membranous nephropathy. It may help reduce long-lasting kidney damage risk when standard treatments like ACE inhibitor or ARB don’t control the protein level.
Bethesda, MarylandAges 18–90 - NCT01276470Recruiting
Study of environmental triggers in anti-synthetase syndrome
This study looks for environmental risk factors that may be linked to anti-synthetase syndrome, a type of inflammatory muscle disease. It compares people with the condition to carefully matched people without it, using questionnaires, blood samples, and lung imaging when needed.
Miami, FloridaAges 2–100 - NCT00001350Recruiting
Understanding Autoimmune Lymphoproliferative Syndrome
This research study helps doctors understand ALPS, a rare immune disorder that causes swollen lymph nodes and spleen. Participating means providing blood samples and health information so researchers can learn how the condition develops and how to better care for patients.
Bethesda, MarylandAges Up to 99 years - NCT00900198Recruiting
Give cancer tissue samples to help future cancer research
This study collects tissue or other cancer-related samples to help researchers better understand cancer and develop better tests or treatments. You can join if you are being evaluated for or treated for cancer, and you agree to let your samples be used for research.
Sacramento, CaliforniaAges 2 months+ - NCT01186913Enrolling by invitation
Natural history study for severe combined immune deficiency (SCID)
This study follows children and adults with SCID and related immune disorders to understand how the illness behaves over time. It also helps researchers learn which testing results and genetic types of SCID match different treatment plans.
Birmingham, AlabamaAges Any age - NCT00001539Recruiting
Lyme disease study's treatment and recovery health
This study looks at the health of people who have had Lyme disease, including those with ongoing symptoms after treatment, and those who have recovered or never had it. It aims to understand the disease and find better ways to manage it.
Bethesda, MarylandAges 13–99 - NCT00040352Recruiting
Melanoma risk in families and individuals
This study looks at people and families with a high risk of melanoma, especially if it runs in the family or is linked to certain genetic conditions. The goal is to better understand what causes melanoma and how to detect it earlier.
Bethesda, MarylandAges 4 weeks–99 years - NCT01143480Recruiting
Testing how the body responds to endotoxin
This study checks how your immune system (your body’s defense system) reacts to a controlled substance that triggers inflammation. It may help researchers understand why some people have stronger or weaker inflammatory responses.
Research Triangle Park, North CarolinaAges 18–100 - NCT00001979Recruiting
Understanding Immune System Kidney Disease
This research study looks at kidney diseases caused by the immune system—conditions where your body's defense system mistakenly attacks the kidneys. Researchers will study your medical history, blood, and urine to better understand these diseases and potentially improve treatment.
Bethesda, MarylandAges 10–99 - NCT00091871Recruiting
Understanding familial high eosinophil disease in families
This study follows families with a genetic condition that causes high levels of white blood cells called eosinophils. Researchers want to understand how the disease develops and changes over time to help predict who may get worse and how to treat it better.
Bethesda, MarylandAges 1–100 - NCT00923442Enrolling by invitation
Study of blood cancers’ biology using stored or new tissue
This trial studies how different blood cancers and early (pre-cancer) blood conditions work, using tumor/blood tissue samples. It may help researchers learn more about disease biology for future treatments, with little to no extra risk if samples come from routine care.
Bethesda, MarylandAges 1–120 - NCT00051857Recruiting
MRI Study of Muscle and Bone Function
This research study uses MRI scans (a safe imaging tool) to understand how bones, muscles, and joints work. Researchers are looking for both people with muscle or bone injuries and healthy volunteers to compare how the body moves and functions.
Bethesda, MarylandAges 5–95 - NCT01143454Recruiting
Study unusual heart conditions and related genetic traits
This study looks at people with unusual or rare heart problems, or people with a family history of these issues. Doctors and researchers may collect and study your blood or tissue (and possibly store samples) to learn what causes the condition and how it may affect the heart.
Washington D.C., District of ColumbiaAges 1–100 - NCT07749092Recruiting
Kimchi powder for gut health in IBS
This study tests whether taking kimchi powder (a dried form of the fermented cabbage dish) can improve gut health and symptoms in people with diarrhea-predominant IBS. You'll avoid regular kimchi for about 2 months, then take the powder daily and track how you feel.
YangsanAges 20–70 - NCT07587931Recruiting
Concentric vs Eccentric Exercise for Partial Rotator Cuff Tears
This study compares two types of shoulder exercises—one where you shorten the muscle and one where you lengthen it—to see which works better for partial tears of your rotator cuff (the muscles that stabilize your shoulder). The goal is to reduce pain and improve shoulder function.
Elâzığ, MErkezAges 18–65 - NCT07728669Recruiting
Digital diet app for people on GLP-1 therapy
This study tests a smartphone app that gives dietary advice to people who are overweight or obese and also take a GLP-1 medication (like semaglutide) for weight or diabetes. The app will help you follow a healthy eating plan while using the medication.
AlmatyAges 21–65 - NCT07750535Recruiting
Liver fat and scarring in wheat-sensitive patients
This study looks at whether people with non-celiac wheat sensitivity or other digestive conditions have more fat in their liver or liver scarring. It aims to understand if wheat-related issues are linked to liver health.
Palermo, PalermoAges 18–65 - NCT07757997Recruiting
Recovery and work after stress treatment
This study checks how people who completed a hospital program for stress-related issues are doing over time, focusing on their health and ability to work. It aims to understand the long-term effects of the treatment.
SüsAges 18–80 - NCT07469592Recruiting
Mindfulness and music therapy for stem cell transplant patients
This trial tests a combined mindfulness and music therapy program delivered through an app or website. It aims to help patients cope with the stress of stem cell transplant for blood cancers like leukemia or lymphoma.
Miami, FloridaAges 18 years+ - NCT07762222Recruiting
Iliac vein stenting for chronic post-thrombotic venous ulcers
This trial tests whether placing a stent (a small mesh tube) in the iliac vein can help heal chronic leg ulcers caused by prior blood clots. The goal is to improve blood flow and reduce symptoms.
CairoAges 18–70 - NCT07762170RecruitingPhase 4
Steroid injections for back and pelvic pain
This study is testing how well and how safely steroid injections work for different types of back pain. If you join, you'll receive the injection as part of your care and fill out surveys about your pain and ability to do daily activities before and after.
Thornhill, OntarioAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,048 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.