Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05924100RecruitingPhase 2
Luspatercept for lower red blood counts in MDS with del5q
This Phase 2 trial studies luspatercept to improve anemia (low red blood cells) in people with MDS that has a del5q change. It also checks safety, especially for people who need red blood cell transfusions and have not benefited from prior standard treatments.
AlessandriaAges 18 years+ - NCT05924347Recruiting
Imaging study to spot early spine changes in at-risk children
This study uses MRI and physical measurements to look for early signs of scoliosis (a side-bending of the spine) in children who are at higher risk. It may help doctors understand when scoliosis starts and improve early monitoring.
UtrechtAges 8–11 - NCT05924646Recruiting
Testing salt to treat POTS symptoms
This study looks at whether adding salt helps improve POTS symptoms, especially the fast heart rate that happens when you stand. You’d be screened carefully to make sure your symptoms fit POTS and that other causes of fast heart rate are unlikely.
Calgary, AlbertaAges 18–60 - NCT05926271RecruitingPhase 2
Genotype-guided clopidogrel alone after stent placement
This trial looks at whether using clopidogrel by itself (without aspirin) works for people after a new drug-eluting stent, based on a blood test of how your body processes the drug. It may help reduce “extra blood-thinning” if you have a certain genetic type that responds well to clopidogrel.
Nieuwegein, UtrechtAges 18 years+ - NCT05927467Recruiting
Study of Alport syndrome patients in a kidney–skin research group
This study follows people diagnosed with Alport syndrome to better understand the condition and its effects. It may help researchers learn what to watch for over time and how the disease progresses.
Paris, Île-de-France RegionAges Any age - NCT05928052Recruiting
Spinal stimulation to help ARDS patients get off the ventilator
This study tests whether stimulating nerves in the spine can help people with severe lung injury (ARDS) breathe without a ventilator sooner. It may help shorten the time you need a breathing machine in the ICU.
Los Angeles, CaliforniaAges 18 years+ - NCT05931718Recruiting
Track diagnosis and treatment in autoimmune blood count disorders
This study follows adults with autoimmune blood problems like autoimmune hemolytic anemia, immune thrombocytopenia, and autoimmune/neutropenia to see how diagnosis and care work over time. You may be asked to complete follow-up visits for up to 3 years.
MilanAges 18 years+ - NCT05936086Recruiting
Testing high-dose cyclophosphamide to treat adult HLH
This trial studies whether giving high-dose cyclophosphamide as an initial treatment works better for adults with HLH. HLH is a serious, overactive immune condition, and the study aims to improve control of the illness and safety.
ChongqingAges 18–65 - NCT05936840Recruiting
Track menstrual cycles with a new monitoring method
This study uses regular testing (including ultrasounds) to monitor menstrual patterns across multiple cycles. It may help people understand and predict menstrual and ovulation-related changes, especially in people with PCOS or those who are athletes.
Calgary, AlbertaAges 18–55 - NCT05937828Recruiting
Caring for children with autoimmune blood disorders in France
This study follows children and teens who have certain autoimmune blood conditions to better understand their illness. It may help doctors learn how these conditions behave over time and improve care.
AmiensAges Up to 17 years - NCT05939739Recruiting
Testing genes in severe language and learning difficulties
This study uses a special DNA test (trio exome sequencing) on a child or young adult and their two biological parents to look for a genetic cause of language and learning difficulties. If a genetic reason is found, it may help explain the cause and guide future care.
DijonAges 3–40 - NCT05943444Recruiting
Compares two ways to preserve bowel function after rectal surgery
This trial compares two surgical techniques to see which one better preserves anal function after surgery for low rectal cancer. If you may be eligible for anal-preserving surgery, it may help your care team choose the approach that best protects bowel control.
Guangzhou, GuangdongAges 18–75 - NCT05946772RecruitingPhase 2
Cyclosporine for Takotsubo heart weakness in the first day
This trial studies whether cyclosporine, an immune-related medicine, can improve outcomes in Takotsubo syndrome (a temporary heart muscle problem). It aims to start treatment very soon after a heart catheter test to help the heart recover.
Bad NauheimAges 18 years+ - NCT05946850Recruiting
Caudal pain block study for adults with chronic pain
This trial looks at giving a specific pain procedure called caudal analgesia to adults with long-term (chronic) pain. It may help reduce pain after the procedure, and it will compare results for people who can safely receive it.
Surrey, British ColumbiaAges 20–99 - NCT05953090Recruiting
Vaginal irritation study with device use and long follow-up
This trial studies a treatment for long-lasting vaginal/vulvar irritation caused by conditions like vaginal atrophy or certain skin conditions of the vulva. You would try the study product/device and be followed over time to see how symptoms recover.
Birmingham, AlabamaAges 18 years+ - NCT05956041RecruitingPhase 2
Pembrolizumab and mogamulizumab for advanced relapsed skin lymphoma
This Phase 2 trial studies two immune medicines (pembrolizumab and mogamulizumab) for people with advanced cutaneous T-cell lymphoma that has come back or did not respond to prior treatment. It aims to control the lymphoma and improve outcomes when the disease is hard to treat.
Ann Arbor, MichiganAges 18 years+ - NCT05957549Recruiting
Tracking early sound perception in young children
This study uses special brain-monitoring tools (fNIRS and EEG) to look at how preschool-aged children process sounds. It may help researchers understand early sound perception differences, especially in children with Fragile X Syndrome.
Cincinnati, OhioAges 2–4 - NCT05960929RecruitingPhase 3
Breathing support for premature babies with lung distress
This Phase 3 trial tests whether InfasurfAero™ (a type of surfactant given as aerosol) works better than a sham treatment in preterm babies with respiratory distress syndrome (RDS). It aims to improve breathing in the first hours of life for babies who need CPAP.
Phoenix, ArizonaAges 7 months–8 months - NCT05969275RecruitingPhase 2
Cell therapy trial for infection-related septic shock in ICU
This Phase 2 trial tests an immune-boosting cell therapy (umbilical mesenchymal stromal cells) in people with septic shock—when infection causes dangerous stress on the heart and other organs. The goal is to see if this treatment can improve outcomes compared with standard care.
Ottawa, OntarioAges 18 years+ - NCT05969860RecruitingPhase 2
Home cancer treatment vs clinic treatment for advanced cancer
This Phase 2 trial compares giving certain standard cancer infusions at home versus in a clinic. It may help people avoid clinic visits while still receiving the same cancer treatment safely.
Jacksonville, FloridaAges 18 years+ - NCT05975671Recruiting
Survey in pediatric ICU to reduce upfront vancomycin use
This study is a survey and quality-improvement effort in participating children’s intensive care units. It aims to understand and change how doctors decide to start vancomycin (an antibiotic) when sepsis is suspected, to improve care and avoid unnecessary use.
Atlanta, GeorgiaAges Any age - NCT05977049Recruiting
Support program for adults with Takotsubo syndrome
This trial studies a psychosocial (emotional and coping) support approach for adults with Takotsubo syndrome. It may help patients deal with stress, anxiety, or adjustment related to the condition.
New York, New YorkAges 18 years+ - NCT05978141Recruiting
T-cell lymphoma registry study
This study creates a registry for people with certain T-cell or NK-cell lymphomas. It collects health information and tumor samples to learn more about these diseases and improve future treatments.
Duarte, CaliforniaAges Any age - NCT05981300Recruiting
Pediatric Gastroparesis Research Registry
This study collects information from children and young adults with gastroparesis (a condition where the stomach empties slowly). It helps researchers understand how this condition affects people over time.
Boston, MassachusettsAges 8–25
Hear when a new Down Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,196 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.