Clinical trials
Endometrial clinical trials
Below are recruiting endometrial clinical trials, each written for real people, not researchers. We’re tracking 356 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05112601RecruitingPhase 2
Nivolumab plus or minus ipilimumab for dMMR endometrial cancer
This Phase 2 study tests the medicines nivolumab (with or without ipilimumab) in people with recurrent endometrial cancer that has “dMMR” (a specific tumor DNA repair defect). It aims to see whether this immune-based treatment can shrink tumors or help them stop growing.
Birmingham, AlabamaAges 18 years+ - NCT07062016Recruiting
Studying high-risk endometrial cancer with blood and tissue tests
This trial studies tumor DNA in blood and tissue from people with aggressive endometrial cancer to better understand the disease. You donate samples during surgery and follow-up visits.
Rochester, MinnesotaAges 18 years+ - NCT05691010RecruitingEarly Phase 1
Short-course radiation plus chemotherapy for endometrial cancer
This early-phase study tests whether giving a short course of radiation together with chemotherapy can help treat endometrial cancer after surgery. It aims to find a treatment plan that is effective while keeping side effects manageable.
Basking Ridge, New JerseyAges 18 years+ - NCT05542407RecruitingPhase 1
ONC201 plus atezolizumab for endometrial cancer and obesity
This Phase 1 study tests ONC201 together with atezolizumab in people with metastatic or returning endometrial cancer, especially when obesity may be driving the cancer. It aims to find a safe dose and see whether the combination can slow the cancer’s growth.
Chapel Hill, North CarolinaAges 18 years+ - NCT06586957RecruitingPhase 1
Study of NKT3964 for advanced solid tumors
This trial tests an experimental drug called NKT3964 for people with certain advanced cancers that have stopped responding to standard treatments. It aims to see if the drug can shrink tumors or slow their growth.
Little Rock, ArkansasAges 19 years+ - NCT06502743RecruitingPhase 2
Study of chemotherapy and pembrolizumab with or without nesuparib for endometrial cancer
This trial tests a chemotherapy combination (carboplatin and paclitaxel) plus the immunotherapy drug pembrolizumab, followed by maintenance pembrolizumab either alone or with a PARP inhibitor called nesuparib. It is for women with advanced or recurrent endometrial cancer that is MMR-proficient (a type where the cells have a normal ability to fix DNA).
Kyeonggi-doAges 19 years+ - NCT06689956Recruiting
Observation after surgery for low-risk endometrial cancer with tiny lymph node findings
This study looks at women with low-risk endometrial cancer who had tiny amounts of cancer cells found in their sentinel lymph nodes during surgery. Doctors want to see if it's safe to avoid additional treatments like chemotherapy or radiation.
Rochester, MinnesotaAges Any age - NCT05950464RecruitingPhase 1
Dose study of two targeted drugs for recurrent ovarian cancer
This Phase 1 trial tests different doses of two study drugs (M1774 and ZEN-3694) for recurrent ovarian cancer and some recurrent endometrial cancers. It aims to find a safe dose and see how well the treatment works, especially in cancers with certain tumor features.
Augusta, GeorgiaAges 18 years+ - NCT05049538Recruiting
Liquid blood tests to predict endometrial cancer return
This trial studies whether blood “liquid biopsies” and tumor genetic testing can help predict whether endometrial cancer will come back after treatment. Results may help doctors plan follow-up and additional care based on a person’s recurrence risk.
Houston, TexasAges 18 years+ - NCT04839614Recruiting
Weight-loss surgery plus uterus surgery for certain uterine lining conditions
This trial tests doing weight-loss surgery at the same time as laparoscopic uterus (womb) surgery for people with certain early uterine lining conditions. It may help lower risk from severe obesity while treating the uterine condition.
Boston, MassachusettsAges 18 years+ - NCT03621904Recruiting
Predicting response to hormone treatment in endometrial cancer
This study looks at whether biopsy test results can help predict how well hormone therapy will work for advanced or recurrent endometrial cancer. It may help doctors choose the most effective hormonal treatment sooner.
NijmegenAges 18–110 - NCT05945407Recruiting
Fertility-sparing treatment for early endometrial cancer
This trial looks at a fertility-preserving treatment plan for people with early-stage endometrial cancer who want to keep the ability to have children. It may help you avoid surgery that removes fertility, if you meet the trial’s safety and eligibility rules.
Beijing, Beijing MunicipalityAges 18–45 - NCT06501846Recruiting
Ultrasound-guided womb lining biopsy for postmenopausal bleeding
This trial tests a new way to take a small sample of the womb lining (biopsy) using a thin, flexible tube guided by ultrasound. The goal is to see if ultrasound guidance makes the biopsy more accurate and comfortable in people with post-menopausal bleeding.
LondonAges 18 years+ - NCT07779109Recruiting
Shorter radiation course for endometrial cancer after surgery
This study tests a shorter, more intense course of radiation therapy after surgery for endometrial cancer. It aims to see if it is safe and works as well as standard radiation, while possibly reducing treatment time.
Zaragoza, ZaragozaAges 18–110 - NCT07675213Recruiting
Uterine muscle movements and pregnancy after frozen embryo transfer
This trial explores how natural uterine contractions affect pregnancy success in women using hormone therapy for frozen embryo transfer. It may help doctors understand if uterine activity influences implantation.
Ho Chi Minh CityAges 18–42 - NCT06450301Recruiting
Studying aging cells in thin uterine lining
This study is looking at aging cells in the lining of the uterus in women who have a thin endometrial lining. It aims to understand what causes this problem and how to improve fertility treatment.
Toronto, OntarioAges 18–39 - NCT07358468Recruiting
How womb lining movement affects frozen embryo transfer success
This study looks at how different ways of preparing the uterus for a frozen embryo transfer affect the natural wavelike movements of the womb lining (endometrial peristalsis). It may help doctors choose the best protocol for you.
Ho Chi Minh CityAges 18–42 - NCT06102863RecruitingPhase 2
Progesterone and statins for young women with early endometrial cancer or atypical hyperplasia
This trial tests whether adding a statin to progesterone therapy helps young women with early endometrial cancer or atypical endometrial hyperplasia who want to preserve their fertility. It aims to find a better treatment option for those who may not respond well to progesterone alone.
Beijing, Beijing MunicipalityAges 17–45 - NCT07077876Recruiting
Endometrial cancer and hyperplasia with conservative treatment
This study looks at women with endometrial adenocarcinoma or atypical hyperplasia who had conservative treatment instead of radical surgery. It aims to check how well the treatment works for both cancer and future pregnancy outcomes.
RomaAges 18 years+ - NCT06280560Recruiting
IVF hormones and womb lining health study
This study looks at how IVF hormone treatments affect the womb lining and whether they cause aging cells to build up. It may help doctors improve IVF success rates.
Valencia, ValenciaAges 18–45 - NCT05997017RecruitingPhase 2
Nab-sirolimus plus letrozole for advanced endometrial cancer
This trial tests a combination of two drugs—nab-sirolimus and letrozole—for people with advanced or returning endometrioid endometrial cancer. The goal is to see if this combination can shrink tumors or slow cancer growth.
Little Rock, ArkansasAges 18 years+ - NCT03422198RecruitingPhase 3
Short course vaginal radiation after hysterectomy
This trial tests a short course of targeted vaginal radiation (brachytherapy) after surgery for certain early endometrial cancer. It may help prevent the cancer from coming back in the vaginal area after the uterus has been removed.
Palo Alto, CaliforniaAges Any age - NCT04073706RecruitingPhase 3
Sentinel node biopsy for early womb cancer
This trial tests whether a less invasive way to check if cancer has spread to lymph nodes (sentinel node biopsy) works as well as the standard method. It is for people with early-stage endometrial cancer having surgery.
Houston, TexasAges 18 years+ - NCT03538665Recruiting
Testing for endometrial and ovarian cancer using tampons
This study checks whether collecting samples using tampons can help detect endometrial and ovarian cancers in people who are already scheduled for certain gynecologic surgeries. It may help researchers improve future early detection tests.
Birmingham, AlabamaAges 18–99
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Common questions
- Are there clinical trials for endometrial?
- Yes. Clin2 currently lists 356 recruiting endometrial studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a endometrial trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a endometrial trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.