Clinical trials
Atypical Endometrial Hyperplasia clinical trials
Below are recruiting atypical endometrial hyperplasia clinical trials, each written for real people, not researchers. We’re tracking 18 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07544680Recruiting
Vaginal fluid test study for endometrial cancer detection
This study tests whether a simple vaginal fluid sample can help detect endometrial cancer (cancer of the uterus lining) or precancerous changes. You'll provide a vaginal specimen alongside your standard medical care, helping researchers develop a non-invasive screening tool.
Sarasota, FloridaAges 18 years+ - NCT03538665Recruiting
Testing for endometrial and ovarian cancer using tampons
This study checks whether collecting samples using tampons can help detect endometrial and ovarian cancers in people who are already scheduled for certain gynecologic surgeries. It may help researchers improve future early detection tests.
Birmingham, AlabamaAges 18–99 - NCT03463252RecruitingPhase 2/Phase 3
Hormone IUD to preserve fertility in early uterine cancer
This study looks at whether a hormone-releasing IUD (LNG-IUS) can treat early-stage endometrial cancer or very early abnormal cell growth while helping you keep the option for future pregnancy. It aims to see how well the treatment works and how it affects fertility-related outcomes.
Chengdu, SichuanAges Up to 40 years - NCT04008563Recruiting
Weight-loss surgery to protect fertility in early womb cancer
This study tests whether bariatric (weight-loss) surgery can help treat certain early, low-grade womb changes while preserving fertility. It’s mainly for people with a higher BMI who want to have children and have an early stage diagnosis confirmed by scans.
Toronto, OntarioAges 18–41 - NCT04362046Recruiting
Fertility-friendly treatment for early uterine cancer or precancer
This trial studies whether removing an early, hormone-responsive uterine growth using a procedure through the cervix can keep fertility possible. It is for people under 40 with a specific low-risk uterine biopsy and MRI findings who have already tried hormone treatment.
Vancouver, British ColumbiaAges 19–39 - NCT05051722Recruiting
Test DNA blood and tissue markers to detect gynecologic cancers
This study looks for “methylated DNA markers” (special DNA patterns) to help detect endometrial, ovarian, and cervical cancers, and to support doctors around planned procedures. It may help find cancer earlier or better sort out who needs closer treatment.
Phoenix, ArizonaAges 18 years+ - NCT05316493RecruitingPhase 2/Phase 3
Weight-loss and progesterone treatments for early uterine lining disease
This trial studies a weight-management approach plus a progesterone-releasing IUD (LNG-IUS) and megestrol to treat endometrial atypical hyperplasia, a high-risk precancer of the uterine lining. It may help shrink or control the abnormal cells while supporting fertility or keeping the uterus.
ShanghaiAges 18–45 - NCT05316935RecruitingPhase 2/Phase 3
Hormone therapy for certain early uterine lining cancers without obesity
This trial tests whether adding GnRH medicine and letrozole to standard progestin treatment can better control early, low-risk endometrial cancer or atypical hyperplasia in people who are not obese. It may help some patients avoid progression while keeping the uterus, especially for those wanting future fertility.
Shanghai, Shanghai MunicipalityAges 18–45 - NCT05647109Recruiting
Test tumor-like cell clusters to predict progesterone response
This study looks at small lab samples taken from early endometrial cancer to see how sensitive the tumor is to progesterone treatment. It may help doctors choose the safest treatment that preserves fertility and the uterus for the right patients.
Beijing, Beijing MunicipalityAges 17–45 - NCT05675787RecruitingPhase 2
Hormone and cholesterol medicines for early womb lining cancer or precancer
This trial tests whether medroxyprogesterone acetate (a progesterone hormone) plus atorvastatin (a cholesterol medicine) can treat early, limited problems in the womb lining—either atypical hyperplasia or early cancer (Grade 1) that has not spread into the muscle wall. It may help shrink or clear the abnormal tissue while supporting keeping fertility and the uterus.
Beijing, Beijing MunicipalityAges 17–45 - NCT06102863RecruitingPhase 2
Progesterone and statins for young women with early endometrial cancer or atypical hyperplasia
This trial tests whether adding a statin to progesterone therapy helps young women with early endometrial cancer or atypical endometrial hyperplasia who want to preserve their fertility. It aims to find a better treatment option for those who may not respond well to progesterone alone.
Beijing, Beijing MunicipalityAges 17–45 - NCT06379113RecruitingPhase 2/Phase 3
Hormone therapy for obesity-linked endometrial cancer that didn't respond to progestin
This trial tests a combination of two hormone-blocking drugs (GnRHa plus letrozole) for women with early-stage, obesity-related endometrial cancer who haven't responded well to standard hormone therapy alone. The goal is to preserve the uterus and fertility while controlling the cancer.
Shanghai, Shanghai MunicipalityAges 18–45 - NCT07077876Recruiting
Endometrial cancer and hyperplasia with conservative treatment
This study looks at women with endometrial adenocarcinoma or atypical hyperplasia who had conservative treatment instead of radical surgery. It aims to check how well the treatment works for both cancer and future pregnancy outcomes.
RomaAges 18 years+ - NCT07377734RecruitingPhase 2
Collagen injection before fertility-sparing therapy for early endometrial cancer
This trial tests whether an injection of type III collagen into the uterus before standard progestin therapy can help preserve fertility in women with very early endometrial cancer or atypical hyperplasia. It is designed for women who want to keep the option of having children.
BeijingAges 18–45 - NCT06365905Recruiting
AI ultrasound test for endometrial cancer after menopause
This study uses an artificial intelligence (AI) tool to analyze ultrasound images of the uterus to see if it can find early signs of endometrial cancer or a condition called atypical hyperplasia (which can lead to cancer). It may help women with postmenopausal bleeding avoid more invasive biopsies.
Scottsdale, ArizonaAges 55 years+ - NCT05903131RecruitingPhase 2
Lifestyle program to help keep the uterus in early cancer
This Phase 2 study tests whether a lifestyle transformation can help treat complex atypical endometrial hyperplasia or early (grade 1) endometrial cancer without removing the uterus. It may help support uterine preservation for people who want to keep fertility or avoid hysterectomy.
St Louis, MissouriAges 18 years+ - NCT06195306RecruitingPhase 2
Low dose tamoxifen and omega-3 for breast cancer prevention
This study tests whether low-dose tamoxifen (a breast cancer prevention drug) or omega-3 supplements can lower breast cancer risk in postmenopausal women who are overweight and have a higher chance of getting the disease. The study lasts about 6 months and involves blood draws and a breast fluid test to see how the treatment affects breast cells.
Kansas City, KansasAges 45–74 - NCT05463796Recruiting
Prevention and early detection for people at high cancer risk
This study looks at surveillance (watching closely), prevention, and early “interception” steps to lower the chance that cancer will develop or be found later. It is for people with genetic risk, past cancer treatment exposures, strong family history, or certain early pre-cancer or high-risk conditions.
Boston, MassachusettsAges Any age
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Common questions
- Are there clinical trials for atypical endometrial hyperplasia?
- Yes. Clin2 currently lists 18 recruiting atypical endometrial hyperplasia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a atypical endometrial hyperplasia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a atypical endometrial hyperplasia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.