Clinical trials
Fatigue clinical trials
Below are recruiting fatigue clinical trials, each written for real people, not researchers. We’re tracking 293 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06170645Recruiting
Vagus nerve stimulation for fatigue in fibromyalgia or long COVID
This trial tests whether a gentle electrical stimulation device on the ear (vagus nerve) can help reduce fatigue when combined with exercise. It is for people with fibromyalgia or long COVID who still feel exhausted after a rehab program.
Saint-EtienneAges 18 years+ - NCT06105307Enrolling by invitation
Improving sleep and fatigue for night shift RNs
This trial uses mobile technology and cognitive-behavioral techniques to help night shift nurses improve their sleep and reduce fatigue. If you work night shifts and have a smartphone, you may be eligible to join.
Cincinnati, OhioAges 18 years+ - NCT06081439Recruiting
Immune markers and mental fatigue in Graves' disease
This study looks at whether certain immune system markers are linked to mental fatigue (feeling tired or foggy in the mind) in people with newly diagnosed Graves' disease. If you join, you'll help researchers understand how your immune system might affect your energy and thinking.
GothenburgAges 18–72 - NCT06085716RecruitingPhase 2/Phase 3
Combination therapy for advanced cancer fatigue
This study tests a combination of treatments (including education and counseling) to see if they can reduce severe fatigue in people with advanced cancer. It's for patients who are seen at MD Anderson Cancer Center in Texas and can attend sessions in person or online.
Houston, TexasAges 18 years+ - NCT05926219Recruiting
Study C-protein changes with fatigue and aging
This study looks at how a blood protein called C-protein relates to fatigue and aging, and how exercise affects it. You may be able to join if you’re otherwise healthy and willing to do muscle testing and activity monitoring.
Eugene, OregonAges 18–80 - NCT05863897Enrolling by invitation
Online program to help long-term fatigue after brain injury
This trial tests an online, blended coaching program for severe fatigue that lasts at least 6 months after a stroke or traumatic brain injury. It may help reduce fatigue by supporting self-management using an internet-based approach.
Wijk aan Zee, North HollandAges 18–70 - NCT05816603RecruitingPhase 2
Stimulation treatment to help post-stroke fatigue
This Phase 2 study tests whether gentle electrical stimulation of the brain can reduce fatigue after a stroke. It may help people who are still bothered by significant tiredness at least 3 months after their stroke.
New York, New YorkAges 18 years+ - NCT05664009Recruiting
Testing Redsenol-1 Plus for cancer-related fatigue
This trial tests a natural supplement for fatigue in cancer survivors. You must have had fatigue for at least a month and be otherwise stable.
London, OntarioAges 18 years+ - NCT05584124RecruitingPhase 2
Brain stimulation to treat fatigue after stroke
This study tests a non-invasive brain stimulation treatment called repetitive transcranial magnetic stimulation (rTMS) to see if it can reduce fatigue after a stroke. If you have ongoing tiredness that started or got worse after your stroke, this treatment might help.
Decatur, GeorgiaAges 34–80 - NCT05487131Recruiting
Brain stimulation study for fatigue in healthy adults
This study tests a form of brain/nerve stimulation to see how it affects fatigue. It is looking for healthy adults, which helps researchers understand the effects without other illnesses.
Norman, OklahomaAges 18–50 - NCT05357781Recruiting
Test immunoglobulin treatment for fatigue in multiple sclerosis
This trial studies whether giving immunoglobulins (antibody medicines) can improve fatigue in people with multiple sclerosis (MS). It will enroll only people whose MS and fatigue are stable and meet specific blood/health criteria.
Bern, Canton of BernAges 18–65 - NCT05333250RecruitingPhase 1/Phase 2
Modafinil to reduce cancer-related fatigue
This trial tests whether modafinil can improve cancer-related fatigue in people with advanced cancer. It may help you feel more able to function day to day by reducing how “worn out” you feel.
Ottawa, OntarioAges 18 years+ - NCT04049331RecruitingPhase 2
Testosterone therapy for cancer survivors with fatigue
This trial tests whether testosterone replacement can help male cancer survivors who have ongoing fatigue and low testosterone levels. It is for men who have completed chemotherapy or radiation and are cancer-free for at least a year.
Boston, MassachusettsAges 18–54 - NCT03940911Recruiting
Testing fatigue and muscle effects after starting targeted therapy
This study looks at how starting “targeted” treatment affects fatigue and skeletal muscle function in people with severe axial spondyloarthritis. It may help doctors understand what to expect early after treatment starts and how well it impacts day-to-day energy and muscle performance.
Strasbourg, Bas-RhinAges 18 years+ - NCT06028022RecruitingPhase 2
Reishi mushroom for fatigue and joint/muscle pain in breast cancer
This trial tests whether a reishi mushroom extract can help reduce fatigue and joint or muscle pain in people with breast cancer who are taking aromatase inhibitors. If you have these symptoms, you may be able to join.
Albert Lea, MinnesotaAges 18 years+ - NCT06855524RecruitingPhase 2
Seaweed supplement for less fatigue during chemotherapy
This study tests whether fucoidan, a supplement from brown seaweed, can help reduce fatigue caused by chemotherapy. Doctors at Mayo Clinic want to see if taking fucoidan during chemo helps you feel less tired.
Scottsdale, ArizonaAges 18 years+ - NCT04335773Recruiting
Study of COVID-19 in hospitalized children
This study looks at children (ages 0 to 18) who are in the hospital with suspected COVID-19. It aims to understand what factors affect outcomes and how the immune system responds.
LørenskogAges Up to 18 years - NCT04118790Recruiting
MRI study of brain microstructure after stroke
This study uses detailed brain MRI scans to learn how brain tissue changes after stroke or a TIA (a brief stroke-like event). It may help researchers better understand brain recovery and improve future care.
Copenhagen, København NVAges 18 years+ - NCT05587777Recruiting
Tracking chronic conditions during standard breast cancer treatment
This study monitors health problems that can happen over time in people with breast cancer while they receive usual treatments like hormone therapy, chemotherapy, and/or radiation. It may help researchers understand which extra symptoms or complications show up and when, to improve care and follow-up.
StavangerAges 19–80 - NCT05502224Recruiting
Program for ongoing fatigue in young cancer survivors
This study tests a multidisciplinary program to help reduce ongoing fatigue after acute cancer treatment. It is for younger adults who still feel at least moderate fatigue about a month after finishing treatment.
BrusselsAges 18–39 - NCT06005246Recruiting
Munich ME/CFS Study for Young People
This study is tracking children, teens, and young adults (up to age 25) who developed ME/CFS after an infection. It aims to better understand the condition in younger people.
Munich, BavariaAges Up to 25 years - NCT07870460Recruiting
Predicting training participation in youth football players
This study uses wearable sensors and machine learning to understand why some elite youth football players reduce their training participation. It aims to help coaches and medical staff better support players.
OlomoucAges 15–19 - NCT05224518Recruiting
Exercise program to improve quality of life in colorectal cancer
This trial tests whether a structured exercise program can improve quality of life for people with colorectal cancer. You may be asked to complete questionnaires in Mandarin/Taiwanese and follow exercise-related study rules to see if symptoms and daily well-being improve.
HsinchuAges 20 years+ - NCT05596474Recruiting
Beetroot juice and light therapy for muscle tiredness
This study tests whether drinking beetroot juice and using a special light on your arm can help reduce muscle tiredness during exercise. It might make your workouts feel easier.
Winston-Salem, North CarolinaAges 65 years+
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Common questions
- Are there clinical trials for fatigue?
- Yes. Clin2 currently lists 293 recruiting fatigue studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a fatigue trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a fatigue trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.