Clinical trials
Fatigue clinical trials
Below are recruiting fatigue clinical trials, each written for real people, not researchers. We’re tracking 293 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06105307Enrolling by invitation
Improving sleep and fatigue for night shift RNs
This trial uses mobile technology and cognitive-behavioral techniques to help night shift nurses improve their sleep and reduce fatigue. If you work night shifts and have a smartphone, you may be eligible to join.
Cincinnati, OhioAges 18 years+ - NCT06081439Recruiting
Immune markers and mental fatigue in Graves' disease
This study looks at whether certain immune system markers are linked to mental fatigue (feeling tired or foggy in the mind) in people with newly diagnosed Graves' disease. If you join, you'll help researchers understand how your immune system might affect your energy and thinking.
GothenburgAges 18–72 - NCT05926219Recruiting
Study C-protein changes with fatigue and aging
This study looks at how a blood protein called C-protein relates to fatigue and aging, and how exercise affects it. You may be able to join if you’re otherwise healthy and willing to do muscle testing and activity monitoring.
Eugene, OregonAges 18–80 - NCT05890599Recruiting
Yoga or health education for ongoing fatigue after COVID
This trial studies whether a yoga program (compared with health education) can reduce persistent tiredness after COVID-19. It may help if your fatigue has lasted at least 12 weeks and you think it started with COVID.
StuttgartAges 18–65 - NCT05880342RecruitingPhase 3
Study how the brain affects fatigue after exercise
This trial studies how your brain responds when you feel mentally and physically tired, using trained healthy volunteers. It may help researchers understand fatigue better, which could guide future treatments for people who struggle with fatigue.
Brussels, Brussels CapitalAges 18–35 - NCT05863897Enrolling by invitation
Online program to help long-term fatigue after brain injury
This trial tests an online, blended coaching program for severe fatigue that lasts at least 6 months after a stroke or traumatic brain injury. It may help reduce fatigue by supporting self-management using an internet-based approach.
Wijk aan Zee, North HollandAges 18–70 - NCT05816603RecruitingPhase 2
Stimulation treatment to help post-stroke fatigue
This Phase 2 study tests whether gentle electrical stimulation of the brain can reduce fatigue after a stroke. It may help people who are still bothered by significant tiredness at least 3 months after their stroke.
New York, New YorkAges 18 years+ - NCT05728229Recruiting
Nutrition program for fatigue after stroke
This study looks at whether a nutrition approach can reduce fatigue in people after a stroke. It will compare the effects of diet-related support during recovery, aiming to help you feel less tired and more active.
Roma, RMAges 55 years+ - NCT05664009Recruiting
Testing Redsenol-1 Plus for cancer-related fatigue
This trial tests a natural supplement for fatigue in cancer survivors. You must have had fatigue for at least a month and be otherwise stable.
London, OntarioAges 18 years+ - NCT05584124RecruitingPhase 2
Brain stimulation to treat fatigue after stroke
This study tests a non-invasive brain stimulation treatment called repetitive transcranial magnetic stimulation (rTMS) to see if it can reduce fatigue after a stroke. If you have ongoing tiredness that started or got worse after your stroke, this treatment might help.
Decatur, GeorgiaAges 34–80 - NCT05531734Recruiting
Study of attention changes during shift work fatigue
This study uses special brain recording to see how fatigue from demanding hospital shifts affects attention in healthy adults. You might help researchers understand fatigue risk and how attention changes during emergency or intensive care work.
GarchesAges 18 years+ - NCT05487131Recruiting
Brain stimulation study for fatigue in healthy adults
This study tests a form of brain/nerve stimulation to see how it affects fatigue. It is looking for healthy adults, which helps researchers understand the effects without other illnesses.
Norman, OklahomaAges 18–50 - NCT05440227RecruitingPhase 2
PG2 shots to reduce moderate to severe breast cancer fatigue
This Phase 2 trial tests whether PG2 injections can safely reduce moderate to severe fatigue in people receiving chemotherapy for locally advanced, recurrent, or metastatic breast cancer. If you qualify, you may be asked to complete questionnaires and follow study plans for about 8 weeks.
TaipeiAges 20 years+ - NCT05333250RecruitingPhase 1/Phase 2
Modafinil to reduce cancer-related fatigue
This trial tests whether modafinil can improve cancer-related fatigue in people with advanced cancer. It may help you feel more able to function day to day by reducing how “worn out” you feel.
Ottawa, OntarioAges 18 years+ - NCT07707648RecruitingEarly Phase 1
Testing ENCER for fatigue during chemo or radiation
This trial tests if ENCER can safely help with cancer-related fatigue. You can join if you're starting a new round of chemo or radiation and can use a smartwatch and answer digital surveys.
Tel AvivAges 18 years+ - NCT05241405Recruiting
American ginseng to reduce fatigue after cancer treatment
This study tests whether taking American ginseng for 8 weeks can lessen long-lasting tiredness (fatigue) in people who recently finished certain breast or gynecologic cancer treatments. It may help reduce fatigue when other causes have been ruled out.
AmiensAges 18 years+ - NCT05013255RecruitingPhase 2
Pioglitazone to treat fatigue in hormone-positive breast cancer
This Phase 2 study tests whether pioglitazone can reduce fatigue in people with certain types of breast cancer. You may be eligible if your cancer is estrogen- and progesterone-positive (ER+/PR+) and you plan surgery soon.
Morgantown, West VirginiaAges 18 years+ - NCT04938362Recruiting
Study brain recovery after abscess using memory and brain scans
This study looks at how thinking and energy levels change after a brain abscess. It may help researchers understand what affects recovery and fatigue, using thinking tests and brain imaging/brain-wave checks.
OsloAges 16 years+ - NCT04151693Recruiting
Group therapy for chronic fatigue syndrome
This trial tests a health-psychology–based rehabilitation program delivered in a group setting for people with chronic fatigue syndrome (ME/CFS). It may help by teaching strategies to cope with symptoms and improving daily functioning through structured group support.
LahtiAges 18–65 - NCT03940911Recruiting
Testing fatigue and muscle effects after starting targeted therapy
This study looks at how starting “targeted” treatment affects fatigue and skeletal muscle function in people with severe axial spondyloarthritis. It may help doctors understand what to expect early after treatment starts and how well it impacts day-to-day energy and muscle performance.
Strasbourg, Bas-RhinAges 18 years+ - NCT03609112Recruiting
Study brain and thinking risks in children with solid tumors
This study looks at how cancer treatment may affect children’s thinking and brain health. It may help doctors better understand risks so they can monitor and support learning and memory during and after treatment.
Villejuif, Val De MarneAges Any age - NCT03675087Recruiting
Testing how exercise affects symptoms in ME/CFS
This trial studies how people with ME/CFS respond to an exercise test. It may help researchers understand what kind of exercise response is typical and how it relates to symptoms.
MadridAges 18–65 - NCT07753122Recruiting
Hydrogen water for chronic fatigue syndrome
This trial tests whether drinking hydrogen water can help with symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). If you have ME/CFS, this study might show if hydrogen water is a helpful treatment.
Stony Brook, New YorkAges 18–65 - NCT07523113Recruiting
Brain Fog Treatment for ME/CFS Using Cognitive Training
This study tests whether a computerized cognitive training program combined with a mild electrical nerve stimulation device (worn on the ear) can help improve thinking and memory problems in people with ME/CFS. The goal is to see if this approach helps with brain fog and daily functioning.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for fatigue?
- Yes. Clin2 currently lists 293 recruiting fatigue studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a fatigue trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a fatigue trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.