Clinical trials
Fragility clinical trials
Below are recruiting fragility clinical trials, each written for real people, not researchers. We’re tracking 50 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07493096Recruiting
Intensive therapy program for children with brain-based conditions
This trial tests an intensive therapy program designed to help children with brain-based conditions like cerebral palsy or autism improve their skills in movement, thinking, and daily activities. The program runs for 2 weeks with daily sessions, and researchers will check for changes in your child's abilities.
The Woodlands, TexasAges 4–12 - NCT05841420RecruitingPhase 2
Lower-intensity chemo for fragile pancreatic cancer patients
This Phase 2 trial compares a standard gemcitabine approach versus a reduced-dose combination chemotherapy for people with pancreatic cancer that can’t be removed by surgery. It aims to find a treatment that works while being safer for “fragile” patients who can’t tolerate full-dose chemotherapy.
AalborgAges 18 years+ - NCT07434037Recruiting
Trust and the brain in Down syndrome and Fragile X
This study explores how people with Down syndrome or Fragile X syndrome learn to trust others. It uses simple tasks and a brain scan (MRI) to compare their responses with those of typically developing children and young adults.
BronAges 3–29 - NCT07039734Recruiting
Ovarian reserve in Fragile X premutation carriers
This study looks at egg supply (ovarian reserve) in women who carry the Fragile X premutation. It aims to understand fertility potential better and help guide future family planning.
Paris, FranceAges 18–40 - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT07029516RecruitingPhase 3
Nail patch study for brittle, fungus-infected or psoriatic nails
This study tests a medicated nail patch to see if it can improve nail fragility, fungal infections (onychomycosis), or psoriasis that covers up to 75% of the nail. It might help if you have nail problems that haven't gotten better with other treatments.
MilanAges 18 years+ - NCT06911619Recruiting
Nutrition support for liver transplant patients
This study tests whether nutritional support can help reduce frailty in patients waiting for a liver transplant. It aims to improve strength and overall health before surgery.
LyonAges 18 years+ - NCT06868979Recruiting
Eye imaging for X-linked disorders
This study uses special eye imaging to look at changes in the brain and eyes of people with creatine transporter deficiency (a condition that affects brain energy) or fragile X syndrome. It aims to find a way to see these brain changes without needing a biopsy or spinal tap.
BronAges 5–60 - NCT05957549Recruiting
Tracking early sound perception in young children
This study uses special brain-monitoring tools (fNIRS and EEG) to look at how preschool-aged children process sounds. It may help researchers understand early sound perception differences, especially in children with Fragile X Syndrome.
Cincinnati, OhioAges 2–4 - NCT06796894Recruiting
Asthma symptoms, breathing, and frailty study
This study looks at symptoms, breathing problems, and frailty in people with allergic or eosinophilic asthma. It aims to understand how these factors relate to each other.
Ankara, StateAges 35–75 - NCT06740162Recruiting
Physical activity program for adults with intellectual disabilities
This study tests a program to help adults with intellectual disabilities become more physically active. You and your caregiver will work with a coach to increase your daily movement, with the goal of improving health and community connection.
Fayetteville, ArkansasAges 18 years+ - NCT06719258Recruiting
Trial on heated humidifiers for breathing tubes
This trial studies how heating and adding moisture to the air breathed through a breathing tube (called a heated humidifier) affects patients in intensive care. It focuses on people who need the breathing tube for a longer time or special protective settings.
Québec, QuebecAges 18 years+ - NCT06560242Recruiting
Tracking early sound perception in Fragile X syndrome
This study uses safe brain monitoring (fNIRS and EEG) to see how infants with Fragile X syndrome process sounds compared to other infants. The goal is to find early signs of hearing or perception issues.
Cincinnati, OhioAges 6 months–2.2 years - NCT05808686RecruitingPhase 2
Exercise-based training for circulation in older, frail adults
This study tests a special exercise training approach to help small blood vessels work better and improve resilience in frail older adults. If you join, you’ll do training that may involve temporary blood-flow restriction, so safety rules are important.
Wauwatosa, WisconsinAges 65–85 - NCT06286891Recruiting
Frailty and lung function after pulmonary endarterectomy
This study looks at how frailty, physical ability, and lung function change in people who have had surgery to remove blood clots from the lungs (pulmonary endarterectomy). It aims to help doctors better understand recovery after this procedure.
São Paulo, São PauloAges 18 years+ - NCT06227780Recruiting
Sound therapy for thinking and sensory issues in kids with developmental disorders
This trial tests whether special sound patterns played through headphones can help improve thinking and reduce sensitivity to noise in children with Fragile X syndrome or autism. The study uses a short daily listening program over several weeks to see if it makes a difference.
Cincinnati, OhioAges 5–10 - NCT06147414Recruiting
Blood test for genetic disorders in pregnancy
This study tests a safer blood test to check for certain genetic disorders during pregnancy, instead of an invasive procedure like amniocentesis. It's for pregnant women who are at risk of passing on a known genetic condition.
ParisAges 18 years+ - NCT05845021Recruiting
Screening and referral for bone health after hip or knee surgery
This study looks at a simple plan for surgeons to identify people with low bone strength (osteoporosis) and refer them for bone health care after hip or knee replacement surgery. It may help you get evaluated and treated earlier if you have osteoporosis.
Columbia, MarylandAges 50 years+ - NCT06081348RecruitingPhase 2
Sertraline vs. placebo for anxiety in kids with developmental disorders
This trial compares sertraline (a common antidepressant) to a placebo (a pill with no medicine) to see which better reduces anxiety in children and teens who also have a neurodevelopmental disorder like autism, ADHD, or Tourette's. The goal is to help you and your child understand if this treatment might offer relief from anxiety.
Calgary, AlbertaAges 8–17 - NCT06022159RecruitingPhase 2
Short radiation therapy for older adults with sarcoma
This trial tests a shorter, more convenient radiation schedule (hypofractionated) for older or fragile adults with soft tissue sarcoma in a limb or trunk. It aims to see if this approach is safe and effective before surgery.
BordeauxAges 65 years+ - NCT05301361Enrolling by invitationPhase 1
Test of brain testing during stimulant treatment for ADHD
This trial checks whether a “NIH Toolbox” set of child-friendly tests can detect changes when stimulant medicine is used for ADHD. It may help doctors better measure how well stimulant treatment is working in people with intellectual disability.
Sacramento, CaliforniaAges 6–24 - NCT02635022Recruiting
Care plan plus bone-medicine monitoring after a fracture
This study tests a structured care service to help people manage osteoporosis after a new bone fragility fracture. It aims to improve how you take bone-protecting medicines and to make sure treatment is followed and monitored over time.
HsinchuAges 50 years+ - NCT04787679Recruiting
CT-planned testing to improve hip fracture and replacement care
This study uses your routine pre-surgery CT scan to study a broken or replacement hip bone with computer modeling and lab-style analysis. It aims to help doctors better understand bone healing and improve how hip fractures and replacements are handled.
Miano, MilanoAges 18 years+ - NCT04796350Recruiting
Medicine after hip surgery to help prevent a second hip fracture
This trial tests AGN1 LOEP (a medicine/device placed at the hip surgery site) to help prevent another hip fracture after you’ve had a low-energy hip fracture. You must be eligible for hip repair surgery and be at higher risk for another fracture, with no key exclusions like active cancer or serious kidney disease.
InnsbruckAges 65–91
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Common questions
- Are there clinical trials for fragility?
- Yes. Clin2 currently lists 50 recruiting fragility studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a fragility trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a fragility trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.