Clinical trials
Fragility clinical trials
Below are recruiting fragility clinical trials, each written for real people, not researchers. We’re tracking 50 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07654114RecruitingPhase 2
Testing CTH120 for men with Fragile X syndrome
This trial tests a new medicine called CTH120 to see if it is safe and helpful for adult men with Fragile X syndrome. You may be able to join if you meet certain health and age requirements.
Barcelona, BarcelonaAges 18–45 - NCT06054165Recruiting
Care plan for pelvic fractures from minor falls
This study tests a special care plan for people with pelvic fractures caused by a minor fall (like from standing height). The goal is to see if the plan helps with recovery and early movement.
Almere Stad, FlevolandAges 50 years+ - NCT07677072Recruiting
Studying a blood protein to detect hidden bone fragility
This study looks at a protein called lumican in the blood to see if it can help find women who have fragile bones even if their bone density test looks normal. It's for postmenopausal women who are already getting a bone density scan as part of their routine care.
Küçükçekmece, IstanbulAges 45 years+ - NCT06677866Recruiting
Group therapy for teens with Fragile X or autism
This trial tests if group cognitive behavioral therapy (CBT) can help teens with Fragile X syndrome or autism spectrum disorder improve social and emotional skills. It looks at how teens with these conditions respond to a structured group program.
RomeAges 13–19 - NCT06709365Recruiting
Comparing two surgeries for complex ankle breaks in older adults
This trial tests two ways to fix complicated ankle and lower leg fractures in people over 65. It compares using a nail through the heel versus plates and screws to see which helps you heal and move better.
SohagAges 1–2 - NCT07351123Recruiting
Pelvic fracture treatment study for older adults
This study compares different ways to treat a specific type of pelvic fracture in adults 60 and older. It aims to find which treatment works best for healing and recovery.
Baltimore, MarylandAges 60 years+ - NCT07209462RecruitingPhase 2
MRM-3379 for Fragile X Syndrome in males
This trial tests an investigational medicine called MRM-3379 in males with Fragile X syndrome. It looks at how the medicine affects thinking and behavior over time.
Phoenix, ArizonaAges 13–45 - NCT06975254Recruiting
Smartphone nursing support for hip fracture recovery
This study tests a special nursing program that uses a smartphone app to support people recovering from a hip fracture caused by fragile bones. It aims to improve recovery and prevent future fractures.
Yiwu, ZhejiangAges 18 years+ - NCT06455085Recruiting
Preventing future fractures after a bone break
This study aims to help adults over 50 who had a recent bone fracture (from a minor fall) get better follow-up care to prevent future fractures. You will work with a nurse or coordinator to connect with your primary care doctor and learn about bone health options.
Birmingham, AlabamaAges 50 years+ - NCT06261502RecruitingPhase 2
CBD for Anxiety in Fragile X Syndrome
This trial tests if cannabidiol (CBD) can help with anxiety and improve brain function in people with Fragile X syndrome. Participants will receive CBD or a placebo, and may have brain scans (MRI) or magnetic stimulation (TMS) to see how it works.
Sherbrooke, QuebecAges 7–40 - NCT06088589Recruiting
Speech-in-noise in autism and fragile x
This study measures how well people with autism or fragile X syndrome perceive speech in noisy settings, compared to typically developing individuals. It uses EEG to understand brain activity during listening tasks.
Cincinnati, OhioAges 15–35 - NCT06050668RecruitingPhase 2
Amino acid supplement study for broken hip in older adults
This study tests whether giving extra essential amino acids (building blocks of protein) to older adults hospitalized with a broken femur (thigh bone) can improve their recovery. If you are 65 or older, broke your femur from a simple fall, and are having surgery to fix it, you may be able to join.
Iowa City, IowaAges 65 years+ - NCT05851898RecruitingPhase 4
Tested medicine to prevent depression after hip or leg fractures
This trial studies whether a type of antidepressant medicine (a serotonin–norepinephrine reuptake inhibitor) can prevent depression after a lower-extremity fragility fracture that was treated with surgery. It’s mainly for older adults, and aims to see if starting this medicine early reduces later depression symptoms.
Winston-Salem, North CarolinaAges 65 years+ - NCT04518423Recruiting
Study frailty and fitness changes in older adults living at home
This study looks at how “frailty” (lower strength and resilience) and “pre-frailty” change over time in older adults who live at home. It may help researchers understand what factors affect aging and strength, so future care can start earlier.
OpoleAges 65 years+ - NCT06134908Recruiting
Preventing another fracture after first hip or spine break
This study aims to prevent another fracture in older adults who have just had their first hip or spine fracture from a minor fall. Participants will receive guidance to help strengthen bones and reduce future fracture risk.
ChangshaAges 50 years+ - NCT07733505RecruitingPhase 1
Heated chemotherapy for older women with advanced ovarian cancer
This trial tests a new way to give heated chemotherapy directly into the abdomen during surgery for women aged 70 and older with advanced ovarian cancer. It aims to find a gentler treatment option that may still be effective for those who are more frail.
OdenseAges 70 years+ - NCT07727915Enrolling by invitation
Using genetics to predict chronic disease risk
This trial uses genetic information to help predict your risk of developing chronic diseases. It aims to create a platform that can identify health risks earlier so you can take preventive steps.
Medellín, AntioquiaAges 18–99 - NCT07732257Recruiting
Wireless button sensor study for premature infants
This study tests a small, wireless button-like sensor to monitor vital signs in premature infants in the NICU. It may offer a gentler way to track your baby's health.
Montreal, QuebecAges Any age - NCT07677319Recruiting
Heart surgery after age 75: a study on recovery
This study looks at how well people aged 75 and older recover after emergency heart surgery. It uses a special test to measure frailty and quality of life for one year after surgery.
Bordeaux, FranceAges 75 years+ - NCT07640243Recruiting
Sedation Methods for Bile Duct Drainage Procedures
This study compares different sedation (sleep) methods used during a procedure to drain blocked bile ducts. Researchers want to see which sedation approach gives patients the best experience and fastest recovery.
Ankara, AnkaraAges 18 years+ - NCT07637383Recruiting
Exercise Program to Improve Daily Function in Hospital Care
This study tests whether a structured exercise program can help patients in intermediate care hospitals regain their ability to do everyday activities like walking and self-care. The program is designed for people recovering from illness or injury.
Manresa, BarcelonaAges 65 years+ - NCT04092504Recruiting
Recovery program for older adults after physical trauma
This study looks at an “optimized recovery” plan for people age 65 and older who are in the hospital because of physical trauma. It may help improve how you recover in the hospital, but you must be able to communicate and not be receiving palliative (comfort-focused) care.
GothenburgAges 65 years+ - NCT07597031Recruiting
Digital Lifestyle Platform for People Leaving Hospital Rehab
This study tests whether a smartphone or tablet app can help people stay healthy and active after leaving rehabilitation. The app guides you through daily activities and healthy habits to support your recovery at home.
Bern, Canton of BernAges 18 years+ - NCT07530497Recruiting
Real-world study of iFuse TORQ TNT for pelvic fractures
This study follows patients age 60+ who receive a specific type of pelvic fracture surgery using the iFuse TORQ TNT device. Researchers collect real-world data on how well this treatment works and how patients recover over 12 months.
Rochester, MinnesotaAges 60 years+
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Common questions
- Are there clinical trials for fragility?
- Yes. Clin2 currently lists 50 recruiting fragility studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a fragility trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a fragility trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.