Clinical trials
General Population (no Specific Condition or Disease) clinical trials
Below are recruiting general population (no specific condition or disease) clinical trials, each written for real people, not researchers. We’re tracking 10,548 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04886726RecruitingPhase 1
New medicine to prevent graft-versus-host disease after transplant
This Phase 1 study tests a new combination of medicines to prevent graft-versus-host disease (GVHD) after an allogeneic stem cell transplant. If it works well, it may lower the chance and severity of GVHD, which can affect skin, liver, and the gut.
Detroit, MichiganAges 18–70 - NCT04912739Recruiting
Targeted health conversations in primary care
This study offers targeted health dialogues with people receiving care in primary settings, to see how well these conversations can support health. You may be invited because of your age and where you receive healthcare in Skåne County.
Malmö, Skåne CountyAges 40–70 - NCT04877197Recruiting
Home telehealth coaching to improve mood after heart hospitalization
This Phase 3 study tests a home-based telehealth program (behavioral activation coaching) to improve functioning in people who recently left the hospital after a heart-related event and also have major depression. It may help you feel more able to do everyday activities and better manage depression symptoms.
Charleston, South CarolinaAges 21 years+ - NCT04848623Recruiting
Listening test to find voice clues of long-term health
This study is looking for “vocal biomarkers,” meaning voice patterns that could hint at how well people are doing with chronic (long-term) health conditions. Your participation would involve providing voice samples so researchers can see what voice features relate to health.
LuxembourgAges 15 years+ - NCT04806282Recruiting
Study to track hearing instability and find helpful targets
This study follows adults with hearing instability to better understand what causes it, measure it in new ways, and look for potential treatment targets. If you qualify, you may get hearing and balance-related testing (including scans) over a period of time.
Bethesda, MarylandAges 18–80 - NCT03276923Recruiting
Pregnancy registry for women with autoimmune disease
This study is a pregnancy and health registry for women with autoimmune (immune system) conditions who are trying to become pregnant or are already pregnant. It helps researchers better understand pregnancy outcomes and health needs in autoimmune disease.
Durham, North CarolinaAges Any age - NCT03329274Recruiting
Histiocytosis patient registry for Erdheim-Chester and related diseases
This is a registry (a research database) for people with Erdheim-Chester disease and other related “histiocytosis” conditions. It collects past and future medical information to better understand these illnesses and support future research.
New York, New YorkAges 18 years+ - NCT04800276Recruiting
Exercise program for leg artery disease
This trial tests a supervised exercise program for people with leg pain when walking caused by narrowed leg arteries. The goal is to see if exercise can improve walking ability and quality of life.
Le MansAges 18 years+ - NCT04784364Recruiting
Study of immune treatments at Mount Sinai
This study follows people who are receiving immune-related medications (called biologics or immune modulators) at Mount Sinai. It aims to better understand how these treatments affect the immune system and health over time, which may help improve future care.
New York, New YorkAges 12 years+ - NCT04774536RecruitingPhase 1/Phase 2
CRISPR gene-edited bone marrow transplant for severe sickle cell
This Phase 1/2 study tests a CRISPR-edited bone marrow (stem cell) transplant to treat severe sickle cell disease. It aims to reduce dangerous sickle-related complications by changing the patient’s stem cells before transplant.
Los Angeles, CaliforniaAges 12–35 - NCT04804241RecruitingPhase 2
Senicapoc for early Alzheimer’s symptoms
This Phase 2 study tests whether the drug senicapoc can slow or improve symptoms in people with early Alzheimer’s disease or mild memory impairment. You would have a 50/50 chance of getting senicapoc or a placebo (inactive pill), along with regular study visits and testing.
Sacramento, CaliforniaAges 55–85 - NCT04804202Recruiting
Virtual cycling program for people with Parkinson disease
This study tests whether a virtual, guided stationary bike exercise program is safe and helpful for people with Parkinson disease. It may help improve movement and fitness by letting you ride at home or in a controlled setting while using visual and audio guidance.
Newark, New JerseyAges 45–75 - NCT04848844Recruiting
Congenital heart disease transplant registry study for adults
This study collects and shares anonymous information about adults being considered for a heart transplant because of a congenital (from birth) heart problem or an inherited heart muscle condition. The goal is to better understand these patients and support research that may improve care.
Hamburg, Free and Hanseatic City of HamburgAges 18 years+ - NCT04849806Recruiting
Testing whether heart nerve signals predict COPD symptoms
This study looks at “sympathetic nerve activity” (signals from the nervous system that affect the heart) in adults with chronic obstructive pulmonary disease (COPD). The goal is to see whether these measurements can help predict what happens to people with COPD.
AachenAges 18 years+ - NCT04848740Enrolling by invitation
Tested implant for worsening thin corneas
This trial looks at whether placing a donor-like cornea “lenticule” implant can help people whose cornea is getting worse, becoming thin, and causing blurry or reduced vision. The goal is to see if the implant can improve corneal clarity and vision in progressive disease.
PristinaAges 20–60 - NCT04799470Recruiting
Testing new brain-stimulation patterns for Parkinson’s with DBS
This study tests whether different deep brain stimulation settings can improve symptoms in people with Parkinson’s who already have an implanted DBS system in the subthalamic nucleus (STN). To join, you must already have the specific Medtronic device and show good brain signal and symptom response after surgery.
Omaha, NebraskaAges 19–80 - NCT04850053Recruiting
Using brain-related “seeds” to help diagnose Alzheimer’s disease
This study looks for specific markers (“seeds”) that may help doctors diagnose Alzheimer’s disease and distinguish it from other memory or thinking conditions. If you are in the right age range and can complete memory testing and provide a sample, you may help validate a diagnostic approach.
Beijing, Beijing MunicipalityAges 55–75 - NCT04806347RecruitingPhase 1
Stem cell transplant using a half-matched donor for children and young adults
This trial studies a type of stem cell transplant (bone marrow transplant) that uses a donor who is only half-matched to the patient, often a parent or sibling. It is for children and young adults with certain blood diseases, including sickle cell disease, thalassemia, bone marrow failure, and immune disorders. The transplant aims to replace the diseased blood-forming cells with healthy ones from the donor.
Madison, WisconsinAges 3 months–25 years - NCT04802395Recruiting
KidneyIntelX check for people with diabetes and early kidney disease
This study looks at how well a kidney test tool called KidneyIntelX works in real-world care for people with type 2 diabetes and certain stages of kidney disease. It may help doctors use the tool to better understand kidney risk and guide next steps.
New York, New YorkAges 23 years+ - NCT04833907Enrolling by invitationPhase 1/Phase 2
Gene therapy study for typical Canavan disease in children
This early-phase trial tests a gene therapy medicine (delivered by a one-time infusion) for children with typical Canavan disease. It aims to improve safety and help evaluate whether the treatment may benefit children over time.
Dayton, OhioAges 3 months–5 years - NCT04779320RecruitingPhase 3
Vedolizumab for teens with moderate to severe Crohn's
This trial tests vedolizumab to treat children and teens with moderate to severe Crohn’s disease when standard treatments haven’t worked or caused side effects. It may help reduce gut inflammation and symptoms and help some patients stay healthier over time.
Phoenix, ArizonaAges 2–17 - NCT04833894RecruitingPhase 2/Phase 3
Efgartigimod for children with generalized myasthenia gravis
This trial studies how efgartigimod (given through a vein) behaves in children and whether it is safe and effective for generalized myasthenia gravis. It is designed for children who have not done well enough with standard treatments like steroids or other immune medicines.
Chicago, IllinoisAges 2–18 - NCT04819841RecruitingPhase 1/Phase 2
Gene correction using your own stem cells to improve sickle disease
This trial tests a gene-correction treatment that changes sickle hemoglobin (HbS) into normal hemoglobin (HbA) using your own stem cells. It may help reduce severe sickle cell complications for people with severe disease who meet specific safety and medical criteria.
Los Angeles, CaliforniaAges 12–50 - NCT01245179RecruitingPhase 1
Panobinostat for adults with severe sickle cell
This early-phase study tests panobinostat, a medicine aimed at reducing sickle-cell problems, in adults with severe disease. It’s mainly looking at safety and whether it can improve blood-related issues that drive pain and complications.
Augusta, GeorgiaAges 18 years+
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Common questions
- Are there clinical trials for general population (no specific condition or disease)?
- Yes. Clin2 currently lists 10,548 recruiting general population (no specific condition or disease) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a general population (no specific condition or disease) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a general population (no specific condition or disease) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.