T-cell reduced stem cell transplant for children and young adults
Part of Blood & lymphatic clinical trials.
This Phase 1 trial studies a type of stem cell transplant that removes certain immune cells (called T-cells) to help treat serious blood and immune diseases in children and young adults. It’s meant for patients who need a transplant but may not have an identical donor available in time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 25 or younger (and for some blood disorders, age rules may be different).
- You need a stem cell transplant now, and there is no HLA-identical sibling, and either no matched unrelated donor or time is too urgent to keep searching.
- A half-matched (haploidentical) or closely matched donor is available and agrees to donate using mobilization and blood cell collection.
- You have one of these conditions: certain blood disorders (like sickle cell disease or thalassemia), bone marrow failure, inherited immune problems, or related immune regulation disorders.
- Your health tests are strong enough for transplant, including kidney, liver, heart, and breathing requirements.
- You are not pregnant and do not have HIV infection; you must not have an uncontrolled serious active infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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