Clinical trials
Generalized Anxiety clinical trials
Below are recruiting generalized anxiety clinical trials, each written for real people, not researchers. We’re tracking 101 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04557891Recruiting
Low-intensity ultrasound for generalized anxiety disorder
This trial tests a non-drug brain treatment using low-intensity focused ultrasound to reduce symptoms of generalized anxiety disorder (GAD). It may help if your anxiety has been moderate to severe and you’ve already tried standard medications without enough relief.
Los Angeles, CaliforniaAges 18–65 - NCT06931236Enrolling by invitation
Brain stimulation for anxiety and insomnia
This study tests whether a noninvasive brain stimulation technique called rTMS can help people with both anxiety and insomnia. Treatments target a specific brain region to reduce anxiety and improve sleep.
Hefei, AnhuiAges 15–65 - NCT05393518Recruiting
Study linking brain signals to anxiety in people with epilepsy
This study looks at how brain electrical signals relate to anxiety symptoms in people with drug-resistant epilepsy. It compares people who do (or do not) meet criteria for generalized anxiety disorder, to better understand anxiety in this setting.
BordeauxAges 18–65 - NCT05671419Recruiting
Mindful self-compassion training for anxiety and depression
This study tests whether a structured “mindful self-compassion” program can reduce symptoms of anxiety disorders or depression. It’s meant to help by improving how you relate to yourself during difficult thoughts and feelings.
Washington D.C., District of ColumbiaAges 18–75 - NCT07798063Recruiting
Solution-focused therapy for generalized anxiety
This study tests a type of talk therapy called solution-focused therapy to help young adults with mild to moderate generalized anxiety. It may help you learn practical ways to manage anxiety and improve your well-being.
IslamabadAges 18–29 - NCT06278909Recruiting
Nerve stimulation for stubborn anxiety
This study tests a new, non-invasive treatment using mild electrical stimulation on a nerve in your face (trigeminal nerve) to help with anxiety that hasn't improved with other treatments. It aims to see if this approach is safe and helpful for people with generalized anxiety disorder who have not responded to standard medications.
Kingston, OntarioAges 18–65 - NCT06218030RecruitingPhase 4
L-methylfolate for treatment-resistant anxiety
This study tests whether adding L-methylfolate (a form of vitamin B9) to your current antidepressant can help with generalized anxiety disorder that has not responded to other treatments. It is for adults who are already on a stable dose of an SSRI or SNRI medication.
Kingston, OntarioAges 18–65 - NCT05427708Recruiting
Breathing training to reduce anxiety symptoms
This study tests whether specific respiratory (breathing) training can reduce anxiety symptoms and fear responses. It may help people who have several kinds of anxiety or trauma-related anxiety, especially if they are not on anxiety medicines or only stable on them.
Austin, TexasAges 18 years+ - NCT07028216Recruiting
Mindful Self-Compassion for Anxiety and Depression
This study tests whether a program called Mindful Self-Compassion (MSC) can help people with anxiety or depression who tend to be hard on themselves. You will be assigned to learn MSC either in a group class or online.
Washington D.C., District of ColumbiaAges 18–65 - NCT07228143Recruiting
Stepped care for anxiety in children
This study tests a stepped care approach to treat anxiety disorders in children ages 7 to 17. It starts with a parent-led program and adds more support if needed, aiming to reduce anxiety symptoms.
Houston, TexasAges 7–17 - NCT06661460Recruiting
Online therapy for youths with anxiety disorders
This study tests an online cognitive behavioral therapy program for children and teens (8 to 17 years old) who have specific anxiety disorders. It aims to help reduce anxiety symptoms by providing therapy through a smartphone, tablet, or computer, with support from a caregiver.
Kalmar, Region Kalmar LänAges 8–17 - NCT06937892Recruiting
Metacognitive therapy vs. Cognitive therapy for anxiety
This study compares two different types of therapy for anxiety disorders: metacognitive therapy (which focuses on how you think about your thoughts) versus cognitive-behavioral therapy (which works on changing thoughts and behaviors). It may help you find which approach works best for you.
StockholmAges 18 years+ - NCT07429578Recruiting
Brain stimulation for anxiety and insomnia
This study tests whether a gentle, non-invasive brain stimulation technique (tACS) can help people who have both generalized anxiety and long-term sleep problems. It aims to see if this treatment can reduce anxiety and improve sleep.
São Paulo, São PauloAges 18–65 - NCT06928428Enrolling by invitation
Online talk therapy for depression or anxiety
This study tests if a type of talk therapy called metacognitive therapy, delivered partly online, helps adults with depression or generalized anxiety. It aims to see if this blended approach works well in primary care.
Stockholm, Stockholm CountyAges 18 years+ - NCT06563310Recruiting
Brain Training for Anxiety Using Neurofeedback
This study tests whether a brain-training technique called neurofeedback can help people with certain anxiety disorders learn to change how they think about upsetting situations. Participants will do thinking exercises while an MRI machine measures their brain activity, which helps them see if they are using the right coping strategies.
Ann Arbor, MichiganAges 18–24 - NCT07430800Recruiting
AI-Powered CBT for Anxiety in University Students
This study tests whether personalized computer models can improve cognitive behavioral therapy (a talk therapy that helps change thinking patterns) for anxiety. It's for university students who have mild to moderate anxiety and are comfortable with being recorded during sessions.
Los Angeles, CaliforniaAges 18 years+ - NCT07117058Recruiting
Anxiety and depression screening for young cancer survivors
This study tests a quick tool to identify anxiety or depression in children, teens, and young adults who have finished intensive cancer treatment and are now in remission. It aims to help doctors provide better mental health support.
AngersAges 7–25 - NCT06198023Recruiting
Improving social skills for anxiety and eating disorders
This study looks at whether a program focused on improving social skills can help people with anxiety or eating disorders. It’s for young adults ages 18–30 who have had these conditions in the past year but are currently stable.
Dallas, TexasAges 18–30 - NCT04793828Recruiting
Self-guided online program for certain anxiety disorders
This trial tests “Velibra,” a self-guided online program to help people with anxiety disorders while they are waiting for care. It focuses on panic, social anxiety, and generalized anxiety, and may help by teaching coping skills through lessons and questionnaires.
BerlinAges 18–65 - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT07382323Recruiting
Comparing two talk therapies for anxiety and PTSD
This trial tests two types of therapy — metacognitive therapy and cognitive-behavioral therapy — to see which works better for people with certain anxiety disorders or PTSD. You would be randomly assigned to one of the treatments and attend regular sessions.
StockholmAges 18 years+ - NCT05467683Recruiting
Breathing CO2 test to predict which anxiety therapies won’t work
This study uses a controlled breathing test (inhaling CO2 or breathing faster) to see if it can predict whether exposure-based therapy will help your anxiety disorder. If you are in the right group, the results may help doctors choose more effective treatment earlier.
Boston, MassachusettsAges 18–70 - NCT06942429Recruiting
Comparing stepped vs. tailored care for youth anxiety
This study compares two ways of delivering cognitive behavioral therapy (CBT) to children and teens with anxiety. Participants will receive a treatment plan that is either stepped (starting with simpler options and increasing if needed) or stratified (matched to their specific needs from the start).
LundAges 8–17 - NCT04900064Recruiting
Self-help CBT added to primary care behavioral health
This trial studies whether adding a Swedish self-help version of “CBT” (a structured talking-therapy approach) improves care for adults getting behavioral health support in primary care. It may help people who want support for mental health without needing fully guided therapy sessions.
Varberg, Halland CountyAges 18 years+
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Common questions
- Are there clinical trials for generalized anxiety?
- Yes. Clin2 currently lists 101 recruiting generalized anxiety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a generalized anxiety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a generalized anxiety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.