Clinical trials
Head and Neck Neoplasms clinical trials
Below are recruiting head and neck neoplasms clinical trials, each written for real people, not researchers. We’re tracking 73 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05269381RecruitingPhase 1/Phase 2
Personalized cancer vaccine with pembrolizumab for advanced solid tumors
This trial tests a personalized vaccine made from your tumor's unique markers, combined with the drug pembrolizumab, to help your immune system fight cancer. It is for people with advanced solid tumors who have already tried standard treatments.
Jacksonville, FloridaAges 16 years+ - NCT07778290Recruiting
Boswellia cream to prevent skin irritation from radiation
This trial tests a cream made from boswellia (a natural plant extract) to see if it can prevent skin irritation (radiation dermatitis) caused by radiation therapy for head and neck cancer. If you are about to start radiation, this cream might help protect your skin.
AlexandriaAges 18 years+ - NCT06998069RecruitingPhase 3
Head and neck cancer study for older adults
This trial tests a combination of chemotherapy and immunotherapy followed by radiation for older adults with head and neck cancer. It aims to see if this approach is safe and effective for people aged 65 and older.
Providence, Rhode IslandAges 65 years+ - NCT05544136RecruitingPhase 2
Study of lower radiation and chemo for head and neck cancer
This study tests whether giving lower doses of radiation and chemotherapy is safe and effective for people with certain head and neck cancers. It aims to reduce side effects while keeping the treatment successful.
Basking Ridge, New JerseyAges 18 years+ - NCT03429036Recruiting
Collecting head and neck tissue samples for research
This study collects tissue and fluid samples from people with head and neck disorders to help researchers learn more about these conditions. By donating leftover samples from your regular medical care, you can help advance research without extra procedures.
Washington D.C., District of ColumbiaAges 3–120 - NCT04870762RecruitingTeam says not enrollingPhase 2
3D-printed tongue stents during head and neck radiation
This Phase 2 study tests whether customized 3D-printed stents can be used safely during head and neck radiotherapy. If you’re having radiation (with or without chemotherapy), the stent may help make treatment easier and more precise, potentially improving the experience and outcomes.
Phoenix, ArizonaAges 18 years+ - NCT06997094RecruitingPhase 1
Decitabine plus standard therapy for HPV-negative head and neck cancer
This trial tests whether adding the drug decitabine to standard treatment (surgery and possibly radiation) can help people with a type of head and neck cancer not caused by HPV. You would receive decitabine before surgery, and then continue with standard care after.
Jacksonville, FloridaAges 18 years+ - NCT07741435Recruiting
Simple blood, urine, and saliva test to find cancer early
This study tests a new way to find cancer by looking at DNA in blood, urine, and saliva. It may help detect cancer earlier and monitor how well treatment works.
Bogotá, Bogota D.C.Ages 18 years+ - NCT07711626Recruiting
Foot massage and ear stimulation for head and neck cancer symptoms
This study tests whether foot massage (reflexology) and a mild nerve-stimulation device on the ear can help reduce side effects during chemotherapy and radiation for head and neck cancer.
Hualien CityAges 30–75 - NCT03914378Recruiting
Study how radiation and cisplatin affect hearing in head and neck cancer
This study looks at how radiotherapy, and possibly cisplatin chemotherapy, affect hearing in people treated for head and neck cancer. It may help doctors better predict hearing side effects and plan hearing monitoring or prevention.
ManchesterAges 18 years+ - NCT04075305Recruiting
Study measuring radiation treatment outcomes with an MR-Linac
This study follows what happens when radiation treatment is guided using an MR-Linac (a special machine that combines MRI imaging with radiation). It may help improve how radiation therapy is planned and assessed, especially for people who can safely have MRI scans.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04099290Recruiting
Blood DNA test in newly diagnosed head and neck cancer
This study looks at “circulating tumor DNA” (tumor DNA found in blood) in people with newly diagnosed, locally advanced head and neck squamous cell cancer. Researchers want to see how the blood DNA levels relate to the cancer and how it may guide treatment after surgery.
Chapel Hill, North CarolinaAges 18 years+ - NCT04429542RecruitingPhase 1
Test of an EGFR-targeting drug for advanced solid cancers
This Phase 1 study tests the safety of BCA101 (an EGFR-targeting treatment) alone or combined with pembrolizumab. It may help people with certain EGFR-driven advanced cancers, depending on the tumor type, prior treatments, and required biopsy testing.
La Jolla, CaliforniaAges 18 years+ - NCT04612075Recruiting
PET-MR scan study for head and neck squamous cancer
This study uses a combined PET/MR scan to better look at head and neck squamous cell cancer before or during treatment. It may help doctors see where the cancer is and how far it has spread, to support planning for curative radiation treatment.
TromsøAges 18 years+ - NCT05106608Recruiting
Mobile plus light therapy for dry mouth after head and neck cancer
This study tests whether “photobiomodulation” light therapy, guided by a phone app, can improve chronic dry mouth (xerostomia) in people who finished radiation for head and neck cancer. It may help reduce bothersome mouth dryness and support better day-to-day comfort after treatment.
Granada, GranadaAges 18 years+ - NCT05187091RecruitingPhase 3
Radiation plan that tries to protect swallowing organs
This Phase 3 study compares a standard radiation approach versus a modified approach designed to spare key swallowing and aspiration (choking) related areas and one salivary gland. It may help reduce treatment side effects that affect swallowing and quality of life for certain head and neck cancer patients.
Jhajjar, HaryanaAges 18–70 - NCT05420948RecruitingPhase 2
Pembrolizumab with chemotherapy for returning or spread head cancer
This Phase 2 study tests pembrolizumab (an immunotherapy) plus chemotherapy to treat head and neck cancer that has come back or spread. You might be eligible if standard local treatments won’t be curative and your tumor can be measured on scans.
Chicago, IllinoisAges 18 years+ - NCT05432297Recruiting
Exercise program for people getting treatment for head and neck cancer
This trial tests whether a preventive, structured physical activity program can help people during and around curative treatment for head and neck cancers. It aims to see if exercise is safe and beneficial for strength, function, and well-being during radio(±chemo) therapy.
GothenburgAges 18 years+ - NCT05811936Recruiting
SNAP support tool for head and neck cancer survivors and caregivers
This trial tests a “SNAP” support tool designed for people who have head and neck cancer and the caregiver who helps them. It aims to improve support and coping during and after cancer treatment by involving both the survivor and their main support person.
Charleston, South CarolinaAges 18 years+ - NCT05944237RecruitingPhase 1/Phase 2
Early trial for advanced cancers using HTL0039732
This is a Phase 1/2 study testing how well HTL0039732 works and is tolerated in people with advanced solid tumors that have not responded to standard treatments. It may help by offering a new treatment option and learning which cancer types and body markers respond best.
CambridgeAges 18 years+ - NCT06216171Recruiting
Adaptive radiation therapy for head and neck cancer
This trial tests a new type of radiation therapy that adjusts during treatment for head and neck tumors. It’s for people who haven’t had cancer treatment before and are otherwise in good health.
EssenAges 18 years+ - NCT06256588RecruitingPhase 3
Dostarlimab vs placebo after chemoradiation for head and neck cancer
This study tests whether the immunotherapy drug dostarlimab, given after standard chemoradiation, can keep advanced head and neck cancer from coming back. It is for people who have not had surgery and whose tumors are PD-L1 positive.
Jonesboro, ArkansasAges 18 years+ - NCT06356272Recruiting
Oropharynx cancer biomarker study
This study looks at certain markers (called p16 and HPV) in tumor samples to better understand oropharynx cancer. It may help doctors learn more about the disease and guide future treatments.
Rochester, MinnesotaAges 18 years+ - NCT06642324Recruiting
HPV and genetics in head and neck cancer study
This study looks at how HPV infection and genetic changes relate to head and neck squamous cell carcinoma. If you have this type of cancer, joining could help doctors learn more about the disease and improve future treatments.
Dhaka, Dhaka DivisionAges 18 years+
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Head and Neck Neoplasms trials by city
Studies with a site in or near these metro areas.
Head and Neck Neoplasms trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for head and neck neoplasms?
- Yes. Clin2 currently lists 73 recruiting head and neck neoplasms studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck neoplasms trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck neoplasms trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.