Clin2
NCT05944237Possibly a fitRecruiting

Early trial for advanced cancers using HTL0039732

NeoplasmsProstatic Neoplasms, Castration-ResistantStomach NeoplasmsEsophageal NeoplasmsHead and Neck NeoplasmsColorectal NeoplasmsPancreatic NeoplasmsLung Neoplasms

Part of Cancer, Digestive system, Hormones & metabolism, Kidney & urinary, Lungs & breathing, Women’s health & pregnancy clinical trials.

This is a Phase 1/2 study testing how well HTL0039732 works and is tolerated in people with advanced solid tumors that have not responded to standard treatments. It may help by offering a new treatment option and learning which cancer types and body markers respond best.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
150 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • Be able to sign consent and follow study visits and treatments
  • Have an advanced solid tumor that has stopped responding to standard treatment (or no standard option is suitable)
  • Have at least one tumor spot that can be measured on scans (or, for some cancers, an “assessable” spot)
  • Be well enough to take part: age 18+, and body-function score (ECOG) of 0 or 1, with expected survival of at least ~3 months
  • Have recent or available tumor tissue for testing (archival tissue is allowed; a new biopsy may be requested)
  • Follow timing rules: no chemo/radiotherapy (except some pain-relief radiation) or other cancer medicines in the prior ~4 weeks; no immunotherapy dose in the prior ~12 weeks

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06551142Recruiting· Phase 1
Study of GSK5764227 for advanced solid tumors

This study tests a new drug called GSK5764227 for people with advanced solid tumors. It aims to see if the drug is safe and works against cancer that has stopped responding to other treatments.

Stanford, California
NCT05483400Recruiting· Phase 2
Atezolizumab and tiragolumab study for several solid tumors

This Phase 2 trial tests the cancer medicines atezolizumab and tiragolumab in people with different solid tumors. It aims to see how well these drugs work and what side effects they cause in specific patient groups.

Groningen
NCT06600789Recruiting· Phase 1/Phase 2
Testing a new drug for advanced solid tumors

This trial is testing whether a new drug called CT7439 can help people with advanced solid tumors that have not responded to other treatments. It is a phase 1/2 study that also checks the drug's safety and how well it works.

Dallas, Texas
NCT07090499Recruiting· Phase 1
Study of PF-08046876 for advanced solid tumors

This trial tests a new medicine, PF-08046876, for people with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas. It aims to see if the drug is safe and works against these cancers.

Duarte, California
NCT07163325Recruiting· Phase 1
Testing a new drug for advanced solid tumors

This trial tests a new oral drug called EP102 for people with certain advanced cancers that have stopped responding to standard treatments. It aims to see if the drug is safe and works by targeting a protein called METTL3.

Brussels
NCT04998422Recruiting· Phase 1
First-time drug study for advanced solid tumors

This Phase 1 trial tests a new medicine (HG381) in people with advanced solid tumors to see how safe it is and how it works in the body. It may help if standard treatments have already stopped working or aren’t possible for you.

Chengdu, Sichuan

Hear when a new Neoplasms trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.