Clinical trials
Idiopathic Hypersomnia clinical trials
Below are recruiting idiopathic hypersomnia clinical trials, each written for real people, not researchers. We’re tracking 18 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07646678RecruitingPhase 2/Phase 3
TAK-360 Extension Study for Narcolepsy or Excessive Sleepiness
This is a follow-up study for people who already completed a TAK-360 trial for narcolepsy (a sleep disorder causing sudden sleep attacks) or idiopathic hypersomnia (excessive daytime sleepiness). Researchers want to see if continuing TAK-360 remains safe and effective for you.
Brandon, FloridaAges 18–71 - NCT06812078RecruitingPhase 2
TAK-360 for idiopathic hypersomnia
This study tests an investigational medication called TAK-360 for people with idiopathic hypersomnia (IH), a sleep disorder that causes excessive daytime sleepiness. The goal is to see if the drug can help reduce sleepiness and improve daily function.
Redwood City, CaliforniaAges 18–70 - NCT05837091RecruitingPhase 4
Low-dose sodium oxybate for idiopathic hypersomnia sleepiness
This trial tests whether low-dose sodium oxybate can improve symptoms in adults with idiopathic hypersomnia, a condition that causes excessive sleepiness. You’d likely be asked to pause this standard treatment briefly while baseline testing is completed, and you’d use reliable contraception during and after the study drug.
Phoenix, ArizonaAges 18–65 - NCT06843590RecruitingPhase 2
Study of ALKS 2680 for Idiopathic Hypersomnia
This trial tests a new medicine called ALKS 2680 for people with Idiopathic Hypersomnia (a condition that causes extreme sleepiness without a clear cause). The goal is to see if it is safe and effective at helping you stay awake during the day.
Cullman, AlabamaAges 18–70 - NCT07006233Recruiting
Dietary change study for narcolepsy and hypersomnia
This study tests whether changing your diet to include more animal protein and fat (like a low-carb diet) can improve symptoms of narcolepsy or idiopathic hypersomnia. You'll need to check your ketone levels at home and be willing to make lasting dietary changes.
Macquarie Park, New South WalesAges 18 years+ - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT07500090RecruitingPhase 3
Study of HBS-301 for idiopathic hypersomnia
This trial tests a new medication, HBS-301, in people with idiopathic hypersomnia (a condition causing excessive sleepiness without clear cause). It aims to see if the drug improves wakefulness and is safe.
Birmingham, AlabamaAges 18 years+ - NCT06484348Recruiting
How food affects sleepiness in narcolepsy and hypersomnia
This study explores how what you eat affects your sleepiness and nighttime sleep quality. Researchers want to learn more about these links in people with narcolepsy type 1 or idiopathic hypersomnia.
Clermont-FerrandAges 18–65 - NCT06767683RecruitingPhase 2/Phase 3
Long-term study of ALKS 2680 for narcolepsy and idiopathic hypersomnia
This study is for people with narcolepsy or idiopathic hypersomnia who have already taken part in an earlier ALKS 2680 study. It aims to see how well the medication works and how safe it is when taken for a longer time.
Cullman, AlabamaAges 18–70 - NCT06752668RecruitingPhase 2
Testing ORX750 for narcolepsy and idiopathic hypersomnia
This trial tests an experimental drug called ORX750 for people with narcolepsy or idiopathic hypersomnia. You would need to stop your current sleepiness medicines to see if ORX750 helps reduce daytime sleepiness.
Auburn, AlabamaAges 18–65 - NCT07096674RecruitingPhase 2
Long-term study of ORX750 for narcolepsy and idiopathic hypersomnia
This trial is for people who have already completed the main CRYSTAL-1 study of ORX750. It tests the long-term safety and effects of the drug, so you can continue treatment if it was helping you.
Auburn, AlabamaAges 18–65 - NCT06252571RecruitingPhase 2
Melatonin and light therapy for idiopathic hypersomnia
This trial tests whether taking melatonin at night and using a bright light therapy device in the morning can improve excessive daytime sleepiness in people with idiopathic hypersomnia. It is a double-blind study, meaning neither you nor the doctors will know if you are getting the real treatment or a placebo.
StrasbourgAges 18–40 - NCT07625280RecruitingPhase 3
Twice-nightly treatment for narcolepsy or idiopathic hypersomnia
This study tests whether taking the sleep medicine Xywav two times each night is safe and helps control symptoms better than a placebo. People with narcolepsy or idiopathic hypersomnia may join, including those who have not tried oxybate medicines before.
Los Angeles, CaliforniaAges 18–75 - NCT04330963Recruiting
Cohort study of causes of daytime sleepiness and sleepiness disorders
This study follows people with frequent daytime sleepiness (sometimes from narcolepsy or hypersomnia) and compares them with matched healthy people, including some with sleep apnea. The goal is to better understand what causes sleepiness and to improve how these conditions are recognized and measured.
BernAges 10–70 - NCT05321355Recruiting
Sleep disorder patient registry for narcolepsy and other conditions
This is a research registry that collects information from people with narcolepsy and other neurological sleep disorders. It may help doctors better understand sleep problems and improve future care.
Mainz, Rhineland-PalatinateAges 18–120 - NCT05773872Recruiting
Testing social understanding in narcolepsy and hypersomnia
This study compares “social cognition” (how people recognize and understand others’ thoughts and feelings) in adults with narcolepsy or idiopathic hypersomnia. It may help researchers better understand how these conditions can affect everyday social interactions.
AmiensAges 18 years+ - NCT06457945Recruiting
Mind-wandering and daydreaming in narcolepsy and hypersomnia
This study looks at whether people with narcolepsy or idiopathic hypersomnia have different patterns of daydreaming and mind-wandering compared to others with sleepiness but no clear diagnosis. It helps understand how certain brain states during sleep might affect waking thoughts.
LyonAges 18–65 - NCT05371483Enrolling by invitation
Study effects of narcolepsy and hypersomnia treatments on brain and heart
This study looks at how narcolepsy or idiopathic hypersomnia affects thinking and cardiovascular health, and how usual treatment medications may change those outcomes. It may help researchers understand risks and benefits of common hypersomnia therapies.
Scottsdale, ArizonaAges 18–75
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Idiopathic Hypersomnia trials by city
Studies with a site in or near these metro areas.
Idiopathic Hypersomnia trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for idiopathic hypersomnia?
- Yes. Clin2 currently lists 18 recruiting idiopathic hypersomnia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a idiopathic hypersomnia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a idiopathic hypersomnia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.