Clinical trials
Irreversible Pulpitis clinical trials
Below are recruiting irreversible pulpitis clinical trials, each written for real people, not researchers. We’re tracking 32 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07287709Recruiting
Laser vs. standard treatment for painful adult molars
This study tests if using a laser is better than the usual method for treating painful, inflamed teeth that still have a live nerve. The goal is to save the tooth and reduce pain without removing the nerve entirely.
AlexandriaAges 16–50 - NCT06904781Recruiting
Pulp treatment for baby teeth with severe toothache
This study compares two ways to treat severe tooth decay in baby molars: removing only the top part of the nerve (pulpotomy) versus removing all of the nerve (pulpectomy). It aims to see which method works better for saving the tooth and relieving pain.
IrbidAges 4–9 - NCT05964933Enrolling by invitation
Pulpotomy vs root canal for painful nerve inflammation
This trial compares two treatments for a tooth nerve that is very inflamed and causing lingering pain: a pulpotomy versus a full root canal. It may help you choose the approach that best relieves symptoms and supports healing for the right kind of tooth.
SingaporeAges 12 years+ - NCT07850258Recruiting
Laser vs standard treatment for severe tooth pain
This study compares two ways to treat a severely inflamed tooth nerve (pulpitis) that causes ongoing pain. One method uses a laser, while the other uses standard tools, to see which is better at relieving pain and saving the tooth.
Kütahya, MerkezAges 12–40 - NCT07672873Recruiting
Steroid injection for tooth nerve pain during root canal
This trial tests whether a single injection of dexamethasone (a steroid) near the nerve of a painful lower molar can improve pain relief during a root canal. It's for people with severe tooth nerve pain who haven't taken pain meds recently.
IstanbulAges 18–65 - NCT07483788Recruiting
Comparing two materials for infected tooth nerve treatment
This study compares two materials (MTA and Biodentine) used to treat a painful, infected nerve in a back tooth. Instead of a full root canal, the dentist will remove only the top part of the nerve and seal it. The goal is to see which material works better to save your tooth.
Karachi, SindhAges 18–40 - NCT06640231Recruiting
Sealer activation for reducing pain after root canal
This trial tests if activating a sealer inside a tooth after root canal can reduce pain in the days after treatment. It may help people with a painful lower molar that still has a live nerve.
Cairo, New CairoAges 18–40 - NCT07138287Recruiting
Growth Factor vs Mineral Trioxide for Kids' Permanent Teeth
This study compares two treatments for children’s permanent back teeth with severe, painful nerve inflammation (irreversible pulpitis). It aims to find which approach works better to save the tooth and relieve pain.
MinyaAges 9–16 - NCT07375576Recruiting
Comparing partial nerve removal to root canal for severe tooth pain
This study compares two ways to treat severe tooth pain from advanced decay: a partial nerve removal (pulpotomy) versus a full root canal treatment. It aims to find which approach works better for saving the tooth.
Hatay, AntakyaAges 18–45 - NCT07452614Recruiting
Predicting pulp treatment success with metabolic markers
This trial tests if a metabolic biomarker can predict how well a vital pulp treatment works for tooth pain caused by deep cavities. It aims to help patients keep their natural teeth instead of needing root canals.
BaghdadAges 16–50 - NCT06844448Recruiting
Factors affecting success of vital pulp therapy
This trial looks at how different risk factors affect the success of vital pulp therapy, a treatment that tries to keep the nerve of your tooth healthy after it's been opened during a dental procedure. If you have a tooth that still responds to cold and can be restored, you may be able to join.
BudapestAges 18 years+ - NCT07748676Recruiting
Comparing two rinsing solutions for deep cavities with tooth pain
This study tests whether rinsing the inside of a painful tooth with a special solution (calcium hypochlorite or sodium hypochlorite) after removing the damaged nerve tissue helps preserve the tooth and reduce pain. It's for people with a deep cavity causing severe toothache, and may help avoid a root canal or tooth loss.
Rohtak, HaryanaAges 18–40 - NCT07163975Recruiting
Complete Pulpotomy vs Root Canal for Diabetic Tooth Infection
This study tests whether a less invasive tooth infection treatment (complete pulpotomy) works as well as a standard root canal for people with type 2 diabetes. It is designed for adults with a specific blood sugar level who have an infected lower back tooth.
Rohtak, HaryanaAges 18–70 - NCT07634900Recruiting
Pain relief methods for children's emergency tooth root treatment
This study compares two different numbing techniques used during emergency root canal treatment in children's back lower teeth. Researchers want to see which method works better at relieving pain during the procedure.
Malatya, MalatyaAges 6–14 - NCT07130760Recruiting
Testing two numbing methods for tooth pain in a back molar
This trial compares two ways to numb a painful lower back molar. If you have a tooth infection that needs a root canal, you may receive one of two injection techniques to see which works better.
Ferrol, A coruñaAges 18 years+ - NCT07808684Recruiting
Comparing root canal file designs on debris removal
This study tests two different root canal file designs to see which one removes debris better from the end of the root. It may help people who need a root canal on a tooth with a single root canal.
Minya, Minya GovernorateAges 20–40 - NCT06514053Recruiting
Predicting success of molar pulp treatment
This study looks at whether certain signs in your tooth can help predict if a special type of filling (pulpotomy) will work for deep cavities in back teeth. It may help find the best treatment for you.
Hong KongAges Any age - NCT07759349RecruitingEarly Phase 1
Pain relief choices after root canal treatment
This study compares three different pain relievers to see which works best for pain after a single-visit root canal. It may help find better ways to manage post-procedure discomfort.
Karachi, SindhAges 18–60 - NCT07532200Recruiting
Pain genes and inflammation in tooth root canal treatment
This research study examines how your genes affect pain and inflammation when you have a painful tooth that needs root canal treatment. By studying these responses, researchers hope to better understand why some people experience different levels of pain during dental procedures.
New Delhi, National Capital Territory of DelhiAges 18–50 - NCT07517367RecruitingPhase 4
Cooling before numbing for tooth nerve pain
This study tests whether applying cold to your gum before a numbing injection helps the anesthetic work better for a severely painful lower front tooth. Researchers want to see if this simple cooling step reduces pain during the procedure.
Samsun, AtakumAges 18–60 - NCT07410780Recruiting
Pain after root canal with two different sealers
This trial compares two types of root canal filling materials—bioceramic and calcium hydroxide—to see which one causes less pain after the procedure. If you have a tooth with a live but inflamed nerve, you may be able to join.
Rawalpindi, Punjab ProvinceAges 18–40 - NCT07409896Recruiting
Comparing two numbing shots for painful lower first molars
This study compares two numbing methods for severe tooth pain (pulpitis) in a lower first molar. If you have a tooth that needs a root canal and the pain lingers after cold, this trial may help determine which anesthetic works better for you.
Rawalpindi, Punjab ProvinceAges 18–55 - NCT06854744Recruiting
Olive oil and zinc oxide for baby tooth root canals
This study tests a mixture of olive oil and zinc oxide to treat infected baby molars. It aims to see if this natural treatment works as well as standard medicine for stopping infection and saving the tooth.
Tanta, Gharbia GovernorateAges 4–7 - NCT07340606Recruiting
AI predictions for root canal success in painful molars
This study tests whether an AI tool can help predict if a simpler root canal treatment (pulpotomy) will work for back teeth with adult, painful pulp infections. If successful, it may help avoid more complex procedures.
CairoAges 20–45
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Common questions
- Are there clinical trials for irreversible pulpitis?
- Yes. Clin2 currently lists 32 recruiting irreversible pulpitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a irreversible pulpitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a irreversible pulpitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.