Clinical trials
Knee Arthroplasty clinical trials
Below are recruiting knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 228 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06010979Recruiting
Knee replacement with digital help study
This study looks at knee replacement surgery done with digital tools like robots or computer guidance. It may help people with knee arthritis find better ways to have surgery and recover.
Beijing, Beijing MunicipalityAges Any age - NCT06083480RecruitingPhase 4
Reducing stress to prevent long-term pain after knee replacement
This trial tests if lowering oxidative stress (damage from natural body processes) during knee replacement surgery can prevent chronic pain afterward. It may help people with osteoarthritis who have moderate to severe pain before surgery.
Nashville, TennesseeAges 50 years+ - NCT06251869Recruiting
Electrocautery vs. Scalpel in Joint Replacement Surgery
This trial compares two surgical tools—electrocautery and a cold knife (scalpel)—to see which works better during joint replacement surgery. It aims to find the best way to make incisions, which could mean less bleeding and faster healing.
Cluj-Napoca, ClujAges 18–90 - NCT06264076Recruiting
Ligament balancing in knee replacement
This trial tests a new method of balancing the ligaments during total knee replacement. If you are generally healthy and need a first-time knee replacement due to arthritis, you may be eligible.
Bærums verk, AkershusAges 40 years+ - NCT06280352Recruiting
Robotic vs custom knee replacement trial
This study compares two modern ways of doing knee replacement: robot-assisted surgery versus a custom-made implant tailored to your knee shape. It aims to see which approach leads to better recovery and function for people with osteoarthritis.
Graz, StyriaAges 40–90 - NCT06676189Recruiting
Comparing two types of plastic knee implants for replacement
This study compares two different types of plastic knee implants (polyethylene) used in total knee replacement surgery. The goal is to see which one works best for patients with knee arthritis.
Clermont-FerrandAges 18–90 - NCT07239258Recruiting
Tele-rehab plan for knee replacement recovery
This study tests a special therapy plan delivered through video calls to help people recover after knee replacement surgery. It compares telerehabilitation to in-person therapy to see if it improves pain and movement.
Lahore, Punjab ProvinceAges 50–65 - NCT06891807Recruiting
Robotic vs augmented reality knee replacement
This study compares two advanced technologies for total knee replacement: a robot that uses a CT scan for guidance versus an augmented reality system that uses no scan. The goal is to see which approach leads to better outcomes for patients with osteoarthritis.
Sint-Martens-Latem, Oost-VlaanderenAges 18–85 - NCT06968143Recruiting
Patient Satisfaction With Smart Knee Implants Trial
This trial looks at how satisfied patients are with a new 'smart' knee implant that tracks motion and function. If you are getting a total knee replacement, you might be able to join and help compare the smart implant with standard implants.
Chicago, IllinoisAges 18 years+ - NCT06991231Recruiting
Cryoablation benefits in knee replacement surgery
This trial tests if a special cold treatment (cryoablation) can help reduce pain or improve recovery for people getting knee replacement surgery for arthritis. It might offer an extra option to feel better after the procedure.
New York, New YorkAges 18 years+ - NCT07080814Recruiting
Balance exercises after knee replacement
This study tests whether special balance exercises on a platform can help people who have recently had a knee replacement walk better and feel steadier.
Ankara, YenimahalleAges 18 years+ - NCT07089251RecruitingPhase 4
Epinephrine and tranexamic acid in knee replacement surgery
This study tests if using epinephrine and tranexamic acid together helps reduce bleeding and improve outcomes during knee replacement surgery. It may be a good fit if you are planning to have knee replacement and do not have certain medical conditions or allergies to these medicines.
Riyadh, Riyadh RegionAges 18–70 - NCT07248072Recruiting
Nerve blocks for better recovery after knee replacement
This trial tests two types of nerve blocks—iPACK and BiFeS—to see if they help people feel better and recover faster after total knee replacement surgery. It compares adding these blocks to the usual spinal anesthesia.
ErzurumAges 18–75 - NCT07425457Recruiting
Cold nerve treatment before knee replacement surgery
This trial tests a cold therapy on nerves before knee replacement to reduce pain. It may help you recover with less discomfort after surgery.
AthensAges 18 years+ - NCT07442812Recruiting
Dexamethasone: pill vs. IV for knee replacement recovery
This trial compares two ways of giving dexamethasone (a strong anti-inflammatory) for people having knee replacement surgery. One group gets a pill and the other gets an IV. The goal is to see which method works better for pain, swelling, and recovery.
Istanbul, IstanbulAges 50–80 - NCT07465484Recruiting
Total knee replacement for bow-leg deformity
This study looks at how well total knee replacement works for people who have severe knee arthritis and a bow-leg (varus) deformity. It may help you if you have a lot of knee pain and are considering surgery.
MoscowAges 18 years+ - NCT07524387Recruiting
Nerve blocks for better leg strength after knee replacement
This study compares two types of numbing injections (nerve blocks) used during knee replacement surgery to see which one helps your thigh muscle recover strength faster. Both are standard care options; the trial tests which works better for early movement after surgery.
Ichinomiya, Aichi-kenAges 20 years+ - NCT07577869Recruiting
Nerve blocks for pain relief after knee replacement
This trial tests two types of numbing injections (nerve blocks) around the knee to help manage pain after total knee replacement surgery. The goal is to see if these injections reduce pain and improve recovery compared to standard pain treatment.
Kayseri, KocasinanAges 18–80 - NCT07598552Recruiting
Brain Function Changes After Same-Day Hip or Knee Surgery
This study checks whether patients who have hip or knee replacement surgery and go home the same day experience any temporary changes in thinking or memory. Researchers want to understand how anesthesia and surgery affect the brain in the short term.
SvendborgAges 70 years+ - NCT07630337Recruiting
Cryotherapy to reduce pain medication after knee replacement
This study tests whether applying cold therapy (cryotherapy) after knee replacement surgery helps patients need fewer opioid pain medications than standard care alone. If cryotherapy works, it could help you manage pain more safely after surgery.
Buenos Aires, Buenos AiresAges 18 years+ - NCT07730216Recruiting
Ultrasound-Guided Knee Block Study for Knee Replacement
This study looks at whether using ultrasound to guide a numbing injection around the knee can improve pain control after knee replacement surgery. It aims to make recovery more comfortable.
Konya, KonyaAges 18 years+ - NCT05992064Recruiting
Wearable sensors to track recovery after knee replacement
This study uses a small wearable sensor placed on your leg after knee replacement surgery to track your recovery. It helps doctors see how well you are moving and healing, without extra visits to the hospital.
Frederikshavn, North DenmarkAges 18 years+ - NCT07006545Enrolling by invitation
Getting back to activity after knee replacement
This study looks at how well people can return to daily activities and exercise after total knee replacement surgery. It may help find better ways to guide recovery.
Munich, BavariaAges 18 years+ - NCT07086716Recruiting
Frailty study for hip or knee replacement patients
This study looks at frailty in people who have had a planned hip or knee replacement. It aims to understand how frailty affects recovery.
Rovato, BSAges 18 years+
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Common questions
- Are there clinical trials for knee arthroplasty?
- Yes. Clin2 currently lists 228 recruiting knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.