Clinical trials
Knee Arthroplasty clinical trials
Below are recruiting knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 236 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06080152Recruiting
Wheeled device use after knee replacement
This study observes how people use wheeled devices (like walkers) after a total knee replacement. It helps doctors understand what patients need during recovery.
Redwood City, CaliforniaAges 18–99 - NCT05792189Recruiting
Knee fracture surgery: plates vs knee replacement for older adults
This trial compares two ways to treat certain lower-thigh (distal femur) fractures near the knee: using plates/screws or doing a knee replacement. It aims to see which option works better for recovery and long-term outcomes.
Gainesville, FloridaAges 55–100 - NCT05391828Recruiting
Testing a new knee robot and app support for knee arthritis
This study looks at whether a robot-assisted knee replacement plus remote tracking with an Apple Watch and a smartphone app helps people do better after surgery. You may be eligible if you’re an adult getting a planned (not replacement) knee surgery for arthritis and can use the required devices.
New York, New YorkAges 18 years+ - NCT04576078RecruitingPhase 2
Nefopam for less pain after knee replacement surgery
This Phase 2 study tests whether oral nefopam can reduce pain after total knee replacement done with spinal anesthesia. It looks at whether this medicine works better than the usual post-surgery pain plan and how safely it can be used.
Lyon, LyonAges 18–75 - NCT07813832Recruiting
Recovery study after knee or hip replacement
This study looks at why some people have problems after knee or hip replacement surgery. It follows patients for three years to understand complications and improve care.
MoscowAges 45 years+ - NCT04728542Recruiting
Observational study comparing two osteoporosis treatment approaches
This is an observational study, meaning researchers watch what happens in real life rather than assigning a treatment by chance. It compares outcomes between people using ORIGIN® and VANGUARD® PS, to better understand how these approaches perform.
MainzAges 18 years+ - NCT06902285RecruitingPhase 4
Magnesium supplement for better sleep after joint replacement
This study tests whether taking magnesium L-threonate can improve sleep quality after total knee or hip replacement surgery. It may help you sleep better during recovery.
Miami, FloridaAges 18 years+ - NCT06747494Recruiting
Comparing general vs spinal anesthesia for hip or knee replacement
This study compares two types of anesthesia (general and spinal) for people having a total hip or knee replacement. The goal is to see which approach is better for recovery and overall outcomes.
Miami, FloridaAges 18 years+ - NCT06469177Enrolling by invitation
Pain management app study for joint replacement recovery
This study tests a smartphone tool to help manage pain after hip, knee, or shoulder replacement. It aims to see if using the tool improves your recovery compared to standard care.
Dartmouth, Nova ScotiaAges 19 years+ - NCT06145516Recruiting
Sleep program to ease pain after joint replacement
This study tests whether a sleep program can help with pain after knee or hip replacement. If you have insomnia and arthritis pain, you may be able to join before your surgery.
Uppsala, UpplandAges 18–100 - NCT05788016Recruiting
Help planning an opioid taper before knee or hip surgery
This study looks at a plan to safely reduce (taper) opioid pain medicines before total knee or hip replacement surgery. It may help people who are already taking opioids and are preparing for surgery in the next 1 to 2 months.
Birmingham, AlabamaAges 18 years+ - NCT07799818Recruiting
Joint replacement study for hip or knee
This study looks at how well hip or knee replacements work. If you are already scheduled for a replacement or a revision (a second replacement), you may be able to join.
Bonn, North Rhine-WestphaliaAges 18–100 - NCT06563531Recruiting
Do compression stockings help after hip or knee replacement?
This trial looks at whether compression stockings are still needed for people who have a new hip or knee joint and are following a modern "fast-track" recovery program. It aims to find out if these stockings are necessary to prevent blood clots when people are up and moving quickly after surgery.
BrestAges 18 years+ - NCT05658796Recruiting
Program to reduce opioid use after hip or knee replacement
This trial tests a support program called RXWell to help people use less opioid pain medicine after elective hip or knee replacement surgery. It may help by addressing anxiety and depression symptoms that can affect pain and recovery.
Monroeville, PennsylvaniaAges 18–100 - NCT07153003Enrolling by invitationPhase 4
Tramadol and oxycodone vs oxycodone alone for joint pain
This trial tests if taking two pain relievers (tramadol and oxycodone) together works better than oxycodone alone to control pain after knee or hip replacement surgery. It aims to find a more effective way to manage pain with fewer side effects.
Rochester, MinnesotaAges 18 years+ - NCT06850818Recruiting
Hip and knee implant registry study
This study is creating a registry of patients who have hip or knee replacement surgery or revision surgery at a specific hospital. The goal is to track outcomes and improve care for future patients.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT07872670Recruiting
Virtual reality to help recovery after hip or knee replacement
This study uses virtual reality (a computer-generated 3D environment you wear a headset for) alongside your usual care to help with recovery after hip or knee replacement surgery. It may help reduce pain or improve how well you move after surgery.
Inverness, HighlandsAges 18 years+ - NCT05824845Recruiting
Join a study collecting information for hip or knee replacement care
This study asks people in the UK who are getting their first hip or knee replacement to answer questionnaires and let researchers use linked health data. The goal is to improve understanding of outcomes and help set up future studies for better care.
AshingtonAges 18 years+ - NCT07647354Recruiting
Mako robotic joint replacement surgery registry study
This study collects information from patients undergoing hip or knee replacement surgery with either traditional or robotic-assisted techniques. Researchers track your recovery and joint function to understand how well these procedures work.
Jacksonville, FloridaAges 18 years+ - NCT05685706Recruiting
Study of spine alignment after hip or knee replacement
This study looks at how the alignment of your spine relates to your walking and posture after hip or knee replacement surgery for wear-and-tear arthritis. It may help doctors better understand how to monitor recovery and long-term function.
Taichung, North DistrictAges Any age
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Common questions
- Are there clinical trials for knee arthroplasty?
- Yes. Clin2 currently lists 236 recruiting knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.