Clinical trials
Postoperative Pain Following Knee Arthroplasty clinical trials
Below are recruiting postoperative pain following knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 16 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06208267Recruiting
Tranexamic acid for pain and bleeding after hip or knee replacement
This study tests whether a medicine called tranexamic acid (TXA) can reduce pain, improve movement, and lessen bleeding after hip or knee replacement surgery. It is for adults having their first joint replacement at St. Mary's Hospital.
Montreal, QuebecAges 18 years+ - NCT07539467Enrolling by invitation
Nerve Block and Tourniquet for Knee Surgery Pain Relief
This trial tests whether a nerve block (numbing injection near the thigh) combined with a tourniquet (pressure cuff) after knee replacement surgery reduces pain better than standard care. If it works, it could help patients recover more comfortably with less need for strong pain medications.
AnkaraAges 40–85 - NCT04814082Recruiting
Compare two knee implant types for walking and function
This study compares two designs of knee replacement implants to see how they affect walking, function, and outcomes after surgery. You may be randomly assigned to one of the implant types used for your specific, approved knee replacement.
Baltimore, MarylandAges 18–75 - NCT06083480RecruitingPhase 4
Reducing stress to prevent long-term pain after knee replacement
This trial tests if lowering oxidative stress (damage from natural body processes) during knee replacement surgery can prevent chronic pain afterward. It may help people with osteoarthritis who have moderate to severe pain before surgery.
Nashville, TennesseeAges 50 years+ - NCT06088602Recruiting
Cold therapy for pain after knee replacement
This trial tests a cold treatment called cryoneurolysis to reduce pain after knee replacement surgery. It may help you move better and use less pain medication.
HvidovreAges 18 years+ - NCT06479161RecruitingPhase 2
Oral tranexamic acid study for knee replacement patients
This trial tests if taking tranexamic acid (TXA) as a pill can reduce bleeding after total knee replacement surgery. It may help you if you have knee osteoarthritis and are scheduled for a first-time knee replacement.
Hartford, ConnecticutAges 18–89 - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT07080892Recruiting
Comparing two ways to give a knee nerve block for pain after knee replacement
This study compares two different ways of giving a nerve block (called iPACK) to see which works better for pain after total knee replacement. The goal is to find the best spot for the injection to help you feel more comfortable after surgery.
BratislavaAges 18–80 - NCT07442435Recruiting
Reiki for recovery after knee replacement surgery
This study tests whether adding Reiki (a gentle hands-on relaxation therapy) to standard care helps people feel better and recover more comfortably after a first-time knee replacement. It may be a good fit if you are having your first knee replacement, are not on certain medications, and haven't tried energy therapies before.
SinopAges 18 years+ - NCT07577869Recruiting
Nerve blocks for pain relief after knee replacement
This trial tests two types of numbing injections (nerve blocks) around the knee to help manage pain after total knee replacement surgery. The goal is to see if these injections reduce pain and improve recovery compared to standard pain treatment.
Kayseri, KocasinanAges 18–80 - NCT06800846Enrolling by invitationPhase 4
Pain relief after knee replacement: injection methods compared
This study compares two ways to give pain medicine during knee replacement surgery: one is injected into the bone, the other around the joint. Researchers want to see which works better and may help you recover with less pain.
Khlong Luang, Changwat Pathum ThaniAges 50–80 - NCT07601906Recruiting
Blood Flow Exercise Therapy After Knee Replacement Surgery
This study tests whether special exercises that temporarily reduce blood flow to your leg can help you recover better after knee replacement surgery. It focuses on reducing pain and improving your ability to bend and straighten your knee.
Lahore, Punjab ProvinceAges 50–65 - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80 - NCT06600815Recruiting
Step-by-step numbing shots for pain relief in knee replacement
This study tests whether a special step-by-step numbing injection given before knee replacement surgery can provide better pain relief during and after the procedure. It may help you have less pain and use fewer painkillers after surgery.
Fuzhou, FujianAges 18 years+ - NCT07286513Enrolling by invitation
Study of a new knee replacement implant
This study follows patients who receive a specific type of knee replacement implant called the Persona® SoluTion® PPS, to see how well it works over time. If your surgeon recommends this implant and you meet standard health requirements, you may be able to join.
Denver, ColoradoAges 18 years+ - NCT06040827Recruiting
Study of a knee implant extension for knee replacement
This trial is for adults having their first knee replacement surgery. It tests a special part (tibial extension) of a common knee implant system. Researchers will follow participants over time to see how well it works.
Fayetteville, ArkansasAges 18 years+
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Common questions
- Are there clinical trials for postoperative pain following knee arthroplasty?
- Yes. Clin2 currently lists 16 recruiting postoperative pain following knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a postoperative pain following knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a postoperative pain following knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.