Clinical trials
Knee Pain clinical trials
Below are recruiting knee pain clinical trials, each written for real people, not researchers. We’re tracking 180 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06522620Recruiting
Nerve block for knee pain after total knee replacement
This trial tests whether a nerve block can reduce pain on the back and outer side of the knee after total knee replacement surgery. If effective, it may help you recover more comfortably.
Yinchuan, NingxiaAges 45–80 - NCT07065266Enrolling by invitation
Pain survey for ACL knee surgery patients
This trial is testing a simplified pain questionnaire for people who are having ACL knee surgery. The goal is to see if this shorter questionnaire can effectively measure pain levels after surgery.
Redwood City, CaliforniaAges 18 years+ - NCT07090928RecruitingPhase 4
Numbing medicine for less pain after knee scope surgery
This study tests whether giving bupivacaine (a numbing medicine) around the time of knee arthroscopy can reduce pain at the surgery sites and help you move your knee better after the operation.
Peshawar, KPKAges 18–70 - NCT06208267Recruiting
Tranexamic acid for pain and bleeding after hip or knee replacement
This study tests whether a medicine called tranexamic acid (TXA) can reduce pain, improve movement, and lessen bleeding after hip or knee replacement surgery. It is for adults having their first joint replacement at St. Mary's Hospital.
Montreal, QuebecAges 18 years+ - NCT06603662RecruitingPhase 4
Steroids for sudden osteoarthritis pain in the emergency room
This trial tests if a short course of oral steroids (glucocorticoids) can relieve sudden osteoarthritis pain in the knee, hip, or shoulder for people who come to the emergency department and are well enough to go home.
York, PennsylvaniaAges 18 years+ - NCT07256548Recruiting
Predicting spinal anesthesia duration with machine learning
This trial uses a computer program to predict how long spinal anesthesia will last for patients having knee replacement surgery. It may help doctors plan better care.
Kocaeli, İzmitAges 18 years+ - NCT07069179Recruiting
Choose to Move replacement study for older adults
This study tests a program called Choose to Move Replacement Ready (CTM-RR) designed for older adults. It looks at how well activity coaches and healthcare referral partners can help people get active.
Vancouver, British ColumbiaAges 50 years+ - NCT07145645RecruitingPhase 3
Comparing topical diclofenac to oral ibuprofen for pain from ankle or knee injuries in children
This study compares a topical gel (diclofenac) applied directly to the injury site versus an oral medication (ibuprofen) taken by mouth to see which works better for treating pain from ankle or knee injuries in children. It may offer a way to relieve pain without a pill.
Calgary, AlbertaAges 6–18 - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT07134244Recruiting
Predicting cartilage damage and pain after knee injury or early arthritis
This study uses computer models and MRI scans to predict how knee cartilage and pain may change over time in people with early osteoarthritis or a recent ACL tear. It aims to find better ways to manage these conditions and prevent long-term damage.
Aalborg, North DenmarkAges 18–70 - NCT07437469Recruiting
Binaural beats for pain and anxiety after surgery
This trial tests if listening to binaural beats (a type of sound therapy) after hip or knee replacement surgery can help reduce pain and anxiety. You would receive the sound therapy through headphones while in the recovery room.
Miami, FloridaAges 18–99 - NCT07464860Recruiting
Breathwork for older adults after knee surgery
This study tests a breathing exercise program to help older adults recover after knee replacement surgery. Participants practice controlled breathing at home using a smartphone or computer.
Tucson, ArizonaAges 65 years+
Hear when a new Knee Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for knee pain?
- Yes. Clin2 currently lists 180 recruiting knee pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.