Clinical trials
Lymphedema clinical trials
Below are recruiting lymphedema clinical trials, each written for real people, not researchers. We’re tracking 96 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07472803Recruiting
Body composition study in early breast cancer patients
This study looks at how body composition (muscle and fat) changes over time in people with early-stage breast cancer. It aims to better understand the effects of cancer treatment on the body.
New Taipei City, Xindian DistAges 18 years+ - NCT07297927Recruiting
Lymphatic imaging before and after radiation for breast cancer
This study uses a special dye and imaging to look at the lymph vessels in your arm before and after radiation therapy. The goal is to understand how radiation affects the lymphatic system, which may help prevent arm swelling in the future.
Hwaseong-si, GyeonggidoAges 18 years+ - NCT05910411Recruiting
Compression treatment for leg swelling after blood-flow surgery
This trial studies whether a specific type of compression helps reduce swelling in the leg after a bypass surgery to improve blood flow. It may help people manage “edema” (fluid-related swelling) while healing after revascularization.
Nice, FranceAges 18–99 - NCT07236658Recruiting
Using AI to detect arm problems after breast cancer surgery
This trial uses artificial intelligence (a computer program) to help predict arm and shoulder problems that can happen after breast cancer surgery. It aims to find these issues early so they can be treated better.
AnkaraAges 18 years+ - NCT07154043Recruiting
Comparing compression pump vs. massage for arm swelling
This study compares two therapies for breast cancer-related arm swelling (lymphedema): one uses a machine that pumps air around your arm (intermittent pneumatic compression, or IPC), and the other is a special type of massage (manual lymph drainage, or MLD). The goal is to see if the machine works as well as or better than massage for reducing swelling.
DenizliAges 18–65 - NCT07127003Recruiting
Surgical bypass to prevent arm swelling after lymph node removal
This study tests a surgical bypass (called ILR) to prevent arm swelling (lymphedema) after removing lymph nodes from under the arm during breast cancer surgery. The goal is to see if this extra step helps keep your arm healthy.
Tampa, FloridaAges 18–75 - NCT06912763RecruitingPhase 2
Reversing radiation side effects in head and neck cancer
This trial tests a combined treatment (a statin and a drug that helps blood flow) to reverse long-term swelling and tissue hardening caused by head and neck radiation. It may help people who have had these side effects for more than 6 months.
Houston, TexasAges Any age - NCT06421285Recruiting
Exercise before breast cancer surgery to prevent lymphedema
This trial tests whether doing exercise before surgery can help prevent arm swelling (lymphedema) in women being treated for breast cancer. If you are newly diagnosed, facing chemotherapy first, and can exercise safely, this study might be a good fit.
Seoul, Seoul Special CityAges 20–80 - NCT06866197Recruiting
Robotic system for microsurgery in lymphedema and free flap
This study tests a robotic system (Symani) to help surgeons perform very precise microsurgery, either to reconnect tiny blood vessels during a free flap procedure or to treat lymphedema (chronic swelling). It may help people with lymphedema who have not gotten full relief from compression therapy.
Melbourne, VictoriaAges 18–100 - NCT05300308Recruiting
Studying leg swelling and nighttime urination after pelvic node surgery
This trial looks at why some people develop leg swelling (lymphedema) and frequent nighttime urination (nocturia) after pelvic lymph node surgery for prostate or bladder cancer. It may help doctors better predict and manage these side effects after the operation.
Leuven, FlandersAges 18 years+ - NCT02280733Recruiting
Chronic wound registry for real-world care documentation
This study is a real-world registry that collects information about chronic wounds and ulcers as they’re treated in everyday settings. It may help improve how care is tracked and supported, even if you don’t get a new medicine from the study.
The Woodlands, TexasAges Any age - NCT06725030Recruiting
Robotic surgery for lymphedema (Symani System)
This trial uses a robotic arm called Symani to help surgeons perform more precise microsurgery (working on tiny blood vessels and lymph channels). It is for adults with moderate lymphedema in one arm or leg who have already tried standard lymphedema therapy and still have swelling.
Beverly Hills, CaliforniaAges 22 years+ - NCT06572098Enrolling by invitation
Lymphedema therapy and its effect on stress and antioxidants
This trial tests if a special therapy for arm swelling (lymphedema) after breast cancer treatment can reduce oxidative stress (a sign of cell damage) and boost antioxidants. It may help you if you have stage 2 or 3 lymphedema.
Adana, çukurovaAges 25 years+ - NCT06574022RecruitingPhase 4
Comparing two pain blocks for mastectomy recovery
This trial compares two types of pain blocks (PECS-II and pectoral blocks) to see which works better after mastectomy. The goal is to improve pain control and recovery for patients with breast cancer or high risk.
Cincinnati, OhioAges 18 years+ - NCT06418282Recruiting
Portable compression device for leg swelling
This study tests a new portable device that wraps around your leg to gently squeeze and reduce swelling from lymphedema or vein problems. It aims to see if at-home use can improve symptoms and lower healthcare costs compared to standard care.
New York, New YorkAges 18–100 - NCT06297265Recruiting
Gentle breast massage after lumpectomy for breast cancer
This trial studies whether a special gentle massage technique (manual lymphatic drainage) can help women who have had breast-conserving surgery and will receive whole breast radiation. The goal is to see if it reduces side effects and improves recovery.
Los Angeles, CaliforniaAges 18 years+ - NCT06092892RecruitingPhase 2
Upfront targeted lymph node removal for early breast cancer
This trial is for women age 45 and older with early ER-positive breast cancer that has spread to the lymph nodes under the arm. It tests a surgery approach where the main tumor and only a few key lymph nodes (rather than many) are removed.
Los Angeles, CaliforniaAges 45 years+ - NCT06082206Recruiting
Nerve blocks to prevent long-term pain after breast cancer surgery
This study compares two types of nerve blocks (pectoral nerve block vs. paravertebral block) to see which one better prevents long-term pain after breast cancer surgery.
AsyutAges 20–65 - NCT06041958Recruiting
Shock Wave and Pulsed Field Therapy for Lymphedema
This trial tests two non-invasive therapies—shock wave therapy and pulsed electromagnetic field therapy—to see if they can reduce arm or leg swelling (lymphedema) caused by cancer treatment. It's for people who are at least 20 and have had breast or gynecologic cancer.
Kaohsiung CityAges 20–80 - NCT05628948Recruiting
Donate blood for a heart and metabolism research biobank
This study builds a “biobank,” which is a collection of blood and related samples, to support future research on heart and metabolic (sugar/body-fat) conditions. It may help researchers better understand these diseases and improve future prevention and treatments.
Cleveland, OhioAges 18 years+ - NCT05444361Enrolling by invitation
Ultrasound freezing treatment for pain after mastectomy
This trial tests a “freezing” nerve procedure guided by ultrasound to help reduce pain after mastectomy. It aims to lessen postoperative pain by temporarily calming specific nerves involved in chest wall sensation.
Los Angeles, CaliforniaAges 18 years+ - NCT04194619Recruiting
Study of pregnancy safety in women with rare blood-vessel diseases
This study looks at pregnancy and the early period after birth in women with rare diseases that affect blood vessels. It may help doctors understand risks and improve care for future pregnancies.
AngersAges 18–45 - NCT03941756Recruiting
Lymph bypass before underarm node surgery to prevent swelling
This study looks at whether adding a lymph “bypass” procedure before underarm lymph node surgery can lower the chance of arm or chest swelling (lymphedema) after cancer treatment. It compares people having lymph node surgery for breast cancer with plans for radiation, and a melanoma comparison group.
Houston, TexasAges 18 years+ - NCT00833599Enrolling by invitation
Scan lymph drainage and collect samples for related conditions
This study uses a special light scan after a dye is given to look at how your lymph system drains. It may also include genetic testing for people with a family history of lymph-related disorders to better understand causes.
Houston, TexasAges 3 months+
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Common questions
- Are there clinical trials for lymphedema?
- Yes. Clin2 currently lists 96 recruiting lymphedema studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lymphedema trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lymphedema trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.