Clinical trials
Lymphedema, Lower Limb clinical trials
Below are recruiting lymphedema, lower limb clinical trials, each written for real people, not researchers. We’re tracking 21 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05269264Recruiting
Screening and diagnostic test for leg swelling from lymphedema
This trial is developing a tool to screen for, diagnose, and evaluate lower-limb lymphedema (leg swelling caused by lymph fluid). It may help patients get a more accurate diagnosis and better monitoring of their condition.
LeuvenAges 18 years+ - NCT06038864Recruiting
New screening tool for leg lymphedema
This study is testing a new tool to help doctors screen, diagnose, and track leg swelling (lymphedema). It involves two groups: people starting intensive treatment and people who are already on maintenance therapy.
LeuvenAges 18 years+ - NCT06082349Recruiting
LVA surgery vs sham for cancer-related lymphedema
This study tests a surgery called lymphaticovenous anastomosis (LVA) against a sham (placebo) surgery to see if it helps reduce swelling in people with lymphedema caused by cancer treatment. It is for patients with early-stage lymphedema in one arm or leg that hasn't improved with standard care.
Nijmegen, GelderlandAges 18 years+ - NCT06454734Recruiting
Shock wave therapy for leg lymphedema
This trial tests if shock wave therapy can help reduce leg swelling caused by lymphedema. It is for people with moderate to severe swelling that has affected at least the knee to foot area for 6 months or longer.
BarcelonaAges 18 years+ - NCT06839885Recruiting
Water Therapy for Swelling in One Leg
This trial tests whether water-based therapy (hydrotherapy) can help reduce swelling in one leg caused by lymphedema. It's for people who have already tried standard lymphedema treatment.
IstanbulAges 18–75 - NCT07073586Recruiting
Lymphovenous anastomosis for leg lymphedema
This trial tests if a surgical procedure called lymphovenous anastomosis (LVA) can reduce swelling in the leg caused by lymphedema. It's for people with mild to moderate lymphedema who have been cancer-free for at least one year.
Odense, FynAges 18 years+ - NCT07472543Recruiting
Virtual reality exercises for leg lymphedema after cancer surgery
This trial tests whether virtual reality-based exercises can help reduce leg swelling caused by lymphedema after gynecological or other cancer surgery. It may be a good option if you have lymphedema in one leg and can commit to daily sessions for a month.
AnkaraAges 18–65 - NCT07558317Recruiting
Resistance Exercise for Lower Leg Swelling
This study tests whether strength-training exercises can help reduce swelling in the lower leg caused by lymphedema. You'll wear compression garments as usual and add supervised resistance exercises to see if they improve your symptoms and quality of life.
HerlevAges 18 years+ - NCT07198698Enrolling by invitation
Sahid method for leg swelling after surgery, infection, or treatment
This study tests a technique called the Sahid method to reduce leg swelling (lymphedema) in women. It might help if you have had swelling in one leg for two years or less due to surgery, infection, cancer, or an injury.
SantiagoAges 30–65 - NCT05793749Recruiting
Prevent leg swelling after gynecologic cancer treatment
This study tests an early approach to help prevent lower-limb lymphedema (chronic leg swelling) after lymph node surgery and radiotherapy for gynecologic cancer. If you’re at risk, it may help your legs stay less swollen and reduce complications.
Chongqing, Chongqing MunicipalityAges 18–60 - NCT05300308Recruiting
Studying leg swelling and nighttime urination after pelvic node surgery
This trial looks at why some people develop leg swelling (lymphedema) and frequent nighttime urination (nocturia) after pelvic lymph node surgery for prostate or bladder cancer. It may help doctors better predict and manage these side effects after the operation.
Leuven, FlandersAges 18 years+ - NCT02914808Recruiting
Study for leg swelling caused by lymph or vein problems
This trial studies how to measure and possibly treat swelling in the legs caused by long-term lymph or vein blockage (primary or secondary lymphoedema, or PTS). It’s looking at people with one type of leg swelling in one leg, and it checks whether MRI scans can be used safely.
Grenoble, IsèreAges 18–99 - NCT07708662Recruiting
Boosted compression for long-term leg swelling
This trial tests a stronger compression method for people with long-lasting leg swelling (edema) that is not caused by another medical condition. The goal is to see if it works better than standard care.
Edegem, AntwerpAges 18 years+ - NCT07613931RecruitingEarly Phase 1
New Compression Device for Leg Lymphedema Treatment
This study tests a newer version of a pneumatic compression device (a machine that gently squeezes your leg to reduce swelling) for lymphedema—persistent swelling in the lower leg or foot. Researchers want to see if the updated compression settings work better to reduce swelling and improve how your leg feels and functions.
Houston, TexasAges 18 years+ - NCT07012642RecruitingEarly Phase 1
GLP-1 drugs for arm or leg swelling (lymphedema)
This trial tests if a class of diabetes drugs (GLP-1 receptor agonists) can reduce swelling in one arm or leg caused by lymphedema. It may help people who have not found relief from other treatments.
Red Bank, New JerseyAges 18 years+ - NCT06228937Recruiting
Gut bacteria and lymphedema with repeated infections
This study looks at the bacteria in your gut and how they relate to lymphedema (swelling) and repeated skin infections in the affected limb. It compares people who have many infections with those who have none, to better understand why some get infections and others don't.
RomeAges 18–85 - NCT06275282Recruiting
Nerve surgery for better leg prosthetic control
This trial tests a new nerve surgery technique to help people with above-knee leg amputations have better control of their prosthetic leg. The goal is to improve how well the prosthesis responds to your movements.
Ann Arbor, MichiganAges 18–75 - NCT06810726RecruitingPhase 2
Platelet-rich fibrin gel for diabetic foot ulcers
This trial tests a special gel made from your own blood (platelet-rich fibrin, or PRF) to help heal diabetic foot ulcers that are not getting better with standard care. It may be an option if you have a mild-to-moderate ulcer on the bottom of your foot with good blood flow and no infection.
Corpus Christi, TexasAges 18–80 - NCT07554443Recruiting
Wearable Device to Improve Balance and Walking in Older Adults
This study tests a wearable device called Walkasins that uses gentle vibrations on your foot to help improve balance and walking ability. It's designed for older adults with nerve damage in their feet who have difficulty with balance.
Jacksonville, FloridaAges 60 years+ - NCT06725602Enrolling by invitation
Prehospital tourniquet study for arms and legs
This trial tests different tourniquet models used in emergencies to stop blood flow in arms and legs. It may help find the best way to control bleeding before reaching a hospital.
Ribeirão Preto, São PauloAges 18–60 - NCT05646316RecruitingPhase 3
Sentinel lymph node mapping to reduce leg swelling after surgery
This study tests whether a special way of finding lymph nodes during hysterectomy can lower the risk of long-term leg swelling or related dysfunction in people with stage I endometrial cancer. It compares standard lymph node assessment with sentinel lymph node mapping and looks at how this affects day-to-day leg functioning.
Washington D.C., District of ColumbiaAges 18 years+
Hear when a new Lymphedema, Lower Limb trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for lymphedema, lower limb?
- Yes. Clin2 currently lists 21 recruiting lymphedema, lower limb studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lymphedema, lower limb trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lymphedema, lower limb trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.