Clinical trials
Melanoma clinical trials
A serious form of skin cancer that develops in pigment-producing cells. We’re tracking 465 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06754904Recruiting
Skipping lymph node removal for melanoma with good treatment response
This trial tests whether patients with stage 3 melanoma that shrinks significantly after initial immunotherapy can safely avoid having all their lymph nodes surgically removed. Instead, only the main affected node is removed for testing.
Rotterdam, South HollandAges 16 years+ - NCT06765850Recruiting
Melanoma blood marker study
This study looks at small molecules in your blood (called the metabolome) using special tests. Researchers want to see if these molecules change depending on how your melanoma progresses, which may help improve future care.
Dresden, SaxonyAges 18 years+ - NCT06767332Recruiting
EMDR for fear of cancer returning in familial melanoma
This study tests whether EMDR therapy can help reduce the fear of cancer coming back in people who have been diagnosed with familial melanoma. If you often worry about your cancer returning, this treatment might help you feel more at ease.
Leiden, South HollandAges 18 years+ - NCT06774989Recruiting
Drug level monitoring in metastatic melanoma treatment
This trial checks how much of two drugs, encorafenib and binimetinib, remain in your blood while treating advanced melanoma that cannot be removed by surgery. The goal is to learn if drug levels affect how well the treatment works.
Boulogne-BillancourtAges 18 years+ - NCT06794775RecruitingPhase 3
Immunotherapy before surgery for stage III melanoma
This trial is for people with stage III melanoma that can be surgically removed. It compares one immunotherapy drug to a combination of two, to see which works better before surgery.
GothenburgAges 18 years+ - NCT06797297RecruitingPhase 2
Study of IBI363 vs pembrolizumab for advanced mucosal or acral melanoma
This trial tests a new drug, IBI363, compared to the standard drug pembrolizumab (Keytruda) for people with advanced mucosal or acral melanoma who have not had treatment before. It aims to see if IBI363 works better or as well as the usual treatment.
Hefei, AnhuiAges 18 years+ - NCT06831071Recruiting
Melanoma oxygen levels study before lymph node biopsy
This study tests how well a special dye (pimonidazole) can detect low oxygen in melanoma tumors before you have a sentinel lymph node biopsy. It may help doctors understand how oxygen levels affect treatment response.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06861023Recruiting
Rebuilding the nail area after melanoma removal
This study looks at the results of different ways to rebuild the nail area after removing melanoma on a finger or toe. It aims to understand what works best for patients who had this type of surgery.
Nice, Alpes MaritimesAges Any age - NCT06887348Recruiting
Long-term safety study for prior RP1, RP2, or RP3 patients
This study checks the long-term safety of patients who have already received RP1, RP2, or RP3 treatment in a previous study. It helps doctors understand any side effects that may appear over time.
La Jolla, CaliforniaAges 18 years+ - NCT06932757RecruitingPhase 2
Quisinostat after treatment for high-risk uveal melanoma
This trial tests whether taking quisinostat pills after standard treatment can lower the chance of uveal melanoma coming back in people whose original tumor had high-risk features. It is for patients who have finished their eye treatment (surgery or radiation) within the past 6 months and have no signs that the cancer has spread.
Miami, FloridaAges 19 years+ - NCT06961006RecruitingPhase 2
Study of an experimental vaccine plus pembrolizumab for melanoma
This trial tests an experimental personalized cancer vaccine (V940) combined with pembrolizumab (Keytruda) in people with advanced melanoma that cannot be removed by surgery. The goal is to see if this combination helps the immune system fight the cancer better.
Springdale, ArkansasAges 18 years+ - NCT06961357RecruitingPhase 1/Phase 2
CD40L-Enhanced TIL therapy for advanced melanoma
This trial tests a new way to treat advanced melanoma by taking immune cells from your tumor, enhancing them in the lab to fight better, and giving them back to you. It is for people whose melanoma has spread or cannot be removed, and who have already tried standard treatments.
Tampa, FloridaAges 18 years+ - NCT06970236Recruiting
Strength training for eye melanoma survivors
This trial tests whether a high intensity resistance (strength) training program can help people who have been treated for choroidal melanoma (an eye cancer) with plaque brachytherapy. The goal is to improve muscle strength and overall health after cancer treatment.
Valencia, SpainAges 18 years+ - NCT06985056Recruiting
Exercise to reduce symptoms in melanoma patients
This trial tests if a supervised exercise program can help reduce symptoms like fatigue and improve well-being in people with advanced melanoma who are already on immunotherapy or targeted therapy. You would visit the study hospital for training sessions and check-ups.
EssenAges 18 years+ - NCT06994208Recruiting
Melanoma study for adults under 40
This study looks at the characteristics of melanoma in people younger than 40. It may help doctors understand how this cancer affects younger adults.
Genoa, LiguriaAges 18–39 - NCT07015190RecruitingPhase 3
Darovasertib before surgery for eye melanoma
This trial tests a drug called darovasertib given before standard surgery for primary uveal melanoma (a type of eye cancer that hasn't spread). The goal is to see if the drug can shrink the tumor and improve outcomes.
Scottsdale, ArizonaAges 18 years+ - NCT07031830Recruiting
Physical activity program for advanced melanoma patients
This trial tests whether an adapted physical activity program can help patients with advanced melanoma who are receiving immunotherapy or targeted therapy. It aims to support overall well-being during treatment.
RouenAges 18 years+ - NCT07050940Recruiting
Adding a gut supplement to immunotherapy for advanced melanoma
This trial tests whether adding a postbiotic (a gut-health supplement) to a standard immunotherapy called anti-PD-1 makes it work better for people with advanced melanoma that hasn't been treated yet. It may help shrink tumors or slow the cancer's growth.
Bari, BAAges 18 years+ - NCT07112170Recruiting
Radiation to slow melanoma growth after initial treatment
This study tests whether giving precise radiation to a limited number of growing spots can help control melanoma that has spread but is otherwise stable on immunotherapy or targeted therapy. You may join if you have up to 10 growing spots outside the brain that can be safely treated with focused radiation.
Toronto, OntarioAges 18 years+ - NCT07138222Recruiting
Immune therapy and fertility in women and men with melanoma
This study looks at how immune checkpoint inhibitors (a type of immunotherapy) affect fertility and hormone health in premenopausal women and men with melanoma. It aims to understand and manage these side effects while you receive treatment.
Sydney, New South WalesAges 18–60 - NCT07193966RecruitingPhase 1/Phase 2
CAR-T cell therapy for advanced melanoma using NG2 and DLL3 targets
This trial tests a new treatment using your own immune cells (CAR-T cells) that are modified to find and attack melanoma cells with specific markers called NG2 and DLL3. It is for people whose melanoma has spread or come back after standard treatments.
Shenzhen, GuangdongAges 18–75 - NCT07203391RecruitingPhase 1
Tebentafusp and roginolisib for uveal melanoma
This trial tests a combination of two drugs, tebentafusp and roginolisib, for people with uveal melanoma that has spread or can't be removed. It aims to improve how long the immune system stays active against the cancer.
Sydney, New South WalesAges 18 years+ - NCT07206017Recruiting
Chicory root fiber for melanoma patients after surgery
This study tests whether adding a high-fiber chicory root supplement to your diet can help people after melanoma surgery. Researchers want to see if it improves your immune system and gut health to prevent the cancer from coming back.
Groningen, Provincie GroningenAges 18 years+ - NCT07221734RecruitingPhase 3
Testing MB11 versus Opdivo for advanced melanoma
This trial compares a new drug, MB11, to the standard treatment Opdivo for people with advanced melanoma that hasn't been treated yet. The goal is to see if MB11 works just as well.
FunchalAges 18 years+
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Common questions
- Are there clinical trials for melanoma?
- Yes. Clin2 currently lists 465 recruiting melanoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melanoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melanoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.