Clinical trials
Melanoma clinical trials
A serious form of skin cancer that develops in pigment-producing cells. We’re tracking 458 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04658303Recruiting
Study of immune and metabolism changes in in-transit melanoma
This trial studies how the immune system and body metabolism change in people with in-transit melanoma (melanoma spread to nearby skin). It aims to understand what’s happening in these lesions and how that information could guide better treatment.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT04567706Recruiting
Melanoma tissue samples storage for future research
This study is about collecting and storing tissue samples from people affected by melanoma so researchers can use them for future studies. It may help speed up research, but it is mainly about sample storage rather than testing a new treatment.
Columbus, OhioAges Any age - NCT04594187RecruitingPhase 2
Radiation after immunotherapy for melanoma that spread to a sentinel node
This Phase 2 trial tests whether adding radiation to the lymph node area can help people with melanoma that has a positive sentinel lymph node. It is meant for patients without spread to distant organs, who are already planning to receive post-surgery immunotherapy.
Jacksonville, FloridaAges 18 years+ - NCT04474301Recruiting
Quality of life check for people with melanoma during COVID-19
This study looks at how people with melanoma are feeling during the COVID-19 pandemic, including quality of life. You may be asked to share information through surveys or study contact so the researchers can understand needs and concerns.
Houston, TexasAges Any age - NCT04318717RecruitingPhase 2
Pembrolizumab plus radiation for resected mucosal melanoma
This trial studies whether giving pembrolizumab (an immunotherapy) together with a targeted form of radiation can help after surgery for mucosal melanoma. It aims to lower the chance of the cancer coming back and improve outcomes in people whose tumor was removed.
St Louis, MissouriAges 16 years+ - NCT03947385RecruitingPhase 1/Phase 2
First drug test for metastatic uveal melanoma with specific gene changes
This Phase 1/2 trial studies IDE196 in adults with metastatic uveal melanoma that has certain gene mutations or fusions. It’s mainly testing safety and correct dosing, and may help shrink tumors in patients matched to the tumor’s genetic changes.
Los Angeles, CaliforniaAges 18 years+ - NCT03941756Recruiting
Lymph bypass before underarm node surgery to prevent swelling
This study looks at whether adding a lymph “bypass” procedure before underarm lymph node surgery can lower the chance of arm or chest swelling (lymphedema) after cancer treatment. It compares people having lymph node surgery for breast cancer with plans for radiation, and a melanoma comparison group.
Houston, TexasAges 18 years+ - NCT03340129RecruitingPhase 2
Nivolumab plus focused brain radiation for melanoma spread
This trial studies whether giving the immunotherapy drug nivolumab together with targeted brain radiation (not whole-brain radiation) helps people with melanoma that has spread to the brain. It aims to improve brain control while keeping side effects manageable.
Sydney, New South WalesAges 18–120 - NCT02821013RecruitingPhase 3
Testing how long to take PD-1 therapy for melanoma
This trial studies whether people with metastatic melanoma should take PD-1 immunotherapy continuously or only for a limited time. It aims to find a schedule that keeps the cancer under control while possibly reducing treatment burden.
Victoria, MilduraAges 18 years+ - NCT02621021RecruitingPhase 2
Immune cell therapy for advanced melanoma
This trial tests a treatment that uses your own immune cells, called tumor-infiltrating lymphocytes (TILs), to fight melanoma. Some participants also get a drug called pembrolizumab. The goal is to see if this approach can shrink tumors.
Bethesda, MarylandAges 18–72 - NCT01776905Recruiting
Real-time detection of melanoma cells during a test
This trial tests a way to detect circulating melanoma cells (melanoma cells moving in the blood) in real time. If you have melanoma, you may be asked to take part in a session where the team measures your blood during the procedure.
Little Rock, ArkansasAges 18–80 - NCT00040352Recruiting
Melanoma risk in families and individuals
This study looks at people and families with a high risk of melanoma, especially if it runs in the family or is linked to certain genetic conditions. The goal is to better understand what causes melanoma and how to detect it earlier.
Bethesda, MarylandAges 4 weeks–99 years - NCT07870265Recruiting
Blood test for detecting BRAF mutation in melanoma
This trial tests a new blood test to detect a specific gene change (BRAF V600E) in melanoma that has come back. The test uses a technology called CRISPR to find the mutation in a simple blood draw, which could help guide treatment without needing a tissue biopsy.
Brno, BrnoAges 18 years+ - NCT07328516Enrolling by invitation
Farm childhood health study for adult children
This study looks at how early-life exposures on farms might influence long-term health. If you are an adult child of a farmer or farmworker from the Agricultural Health Study, and you spent time on a farm as a child, you may be able to join.
Bethesda, MarylandAges 18–99 - NCT07760012Recruiting
Pet scan with new tracer for solid tumors
This study uses a new imaging tracer, called 68Ga-SorB, during a PET/CT scan to look at tumors. It may help doctors see cancer more clearly. The trial is for adults with certain types of solid tumors (such as melanoma, liver, lung, breast, pancreatic, ovarian, or bile duct cancer) who need a PET/CT scan as part of their care.
Beijing, Beijing MunicipalityAges 18 years+ - NCT03787056Recruiting
Blood test marker study in many cancer types
This study measures a blood marker called progastrin (at diagnosis and during treatment) to see how well it predicts response or outcomes. It may help doctors choose or monitor treatment more precisely for several cancer types.
BronAges 18 years+ - NCT05037825Recruiting
Study gut microbes with immune therapy in several solid cancers
This trial looks at how the gut microbiome (the bacteria in your digestive system) relates to outcomes when you take standard immune “checkpoint” cancer medicines. If you’re eligible, they’ll collect stool samples while you receive treatment for certain cancers.
Elizabethtown, KentuckyAges 18 years+ - NCT05366478RecruitingPhase 1
LM103 for advanced solid tumors using donated immune cells
This Phase 1 study tests LM103 to treat advanced cancers that are not responding to standard treatment. It also looks at whether enough tumor tissue can be collected for immune cell testing, and focuses on safety at first.
TianjinAges 18 years+ - NCT04095195Recruiting
Pancreatic cancer risk registry for high-risk families
This study builds a registry of people with a higher-than-average risk of pancreatic cancer, based on family history or inherited gene conditions. If you join the extra imaging follow-up, it helps your care team monitor risk earlier.
Rozzano, MilanAges 18–80 - NCT06028724Recruiting
Looking for cancer mutations using a blood test
This study uses a blood test (liquid biopsy) to find genetic changes in advanced solid tumors. It may help doctors choose the right treatment and monitor how well it works over time.
Aviano, PordononeAges 18 years+ - NCT05794035Recruiting
Shorter radiation after skin cancer surgery for older adults
This study looks at whether giving a shorter course of radiation after surgery can help prevent skin cancer from coming back in people age 70 and older. It focuses on higher-risk skin cancers and checks how well the treatment works and what side effects occur.
CréteilAges 70 years+ - NCT05746897RecruitingPhase 1
First-in-human test of an anti-PVRIG drug for advanced cancers
This early-phase study tests NM1F (an anti-PVRIG antibody) in people with advanced solid tumors to see if it’s safe and whether it may work. It also includes pembrolizumab (a PD-1 “checkpoint” medicine), aiming to boost the immune system against the cancer.
Dallas, TexasAges 18 years+ - NCT06229340RecruitingPhase 2
Two drug combinations for advanced cancer with RAS mutations
This trial tests two different treatment combinations (leflunomide alone or with MEK inhibitor and hydroxychloroquine) in people with advanced cancer that has a RAS mutation and has not responded to at least two prior therapies.
Saint PetersburgAges 18–85 - NCT04282044RecruitingPhase 1
CRX100 drug trial for advanced cancers with or without pembrolizumab
This Phase 1 trial tests CRX100 (a new cancer medicine) alone and with pembrolizumab (an immune checkpoint drug) in people with advanced solid tumors. It’s mainly designed to check safety and side effects, and to see whether tumors respond, potentially helping people whose cancer has come back or stopped responding to standard treatment.
Scottsdale, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for melanoma?
- Yes. Clin2 currently lists 458 recruiting melanoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melanoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melanoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.