Clinical trials
Melanoma clinical trials
A serious form of skin cancer that develops in pigment-producing cells. We’re tracking 459 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03740503Recruiting
Study genes in people who respond unusually to treatment
This study looks at stored tumor samples to understand why some people respond much better or much worse than expected. The goal is to learn what the tumor’s genes might be telling doctors about response to treatment.
Toronto, OntarioAges 18 years+ - NCT03755739RecruitingPhase 2/Phase 3
Checkpoint cancer drug given into or near tumors
This trial studies whether giving immunotherapy “checkpoint inhibitor” medicine directly into the tumor area (and/or the artery feeding it), along with a chemotherapy-style drug, can work better for advanced solid tumors. It aims to boost the immune system’s ability to attack cancer while still being safe for people with measurable tumors.
Guanzhou, GuangdongAges 18 years+ - NCT03829254RecruitingPhase 1/Phase 2
NUC-7738 treatment for advanced solid cancers and lymphoma
This early-phase study tests how safe NUC-7738 is and how it works in people with advanced solid tumors and certain lymphomas. Some participants may also receive pembrolizumab for specific cancers, aiming to improve cancer control while carefully monitoring side effects.
CambridgeAges 18 years+ - NCT03685890RecruitingPhase 1/Phase 2
Testing nivolumab for melanoma spread to the limb skin
This trial studies nivolumab, an immune medicine, for melanoma that has spread to the skin along a limb (called in-transit metastases). It’s given after a procedure that delivers higher treatment levels to the affected limb, with the goal of shrinking the melanoma and improving outcomes.
AmsterdamAges 18 years+ - NCT03702309Recruiting
Banking and testing blood samples to study cancer
This study collects blood samples to “test and store” (bank) information that may help doctors understand cancer in the future. You might be able to join if you’re an adult with confirmed cancer or a higher-than-usual risk for cancer.
Toronto, OntarioAges 18 years+ - NCT03452774Recruiting
AI matches your cancer tests to possible treatment trials
This trial uses an AI system to help match people with certain cancer types and specific tumor test results (like gene or protein markers) to relevant clinical trials. It may help you and your doctor find studies that fit your cancer biology faster.
Birmingham, AlabamaAges Any age - NCT03340506RecruitingPhase 4
Follow-on treatment study for dabrafenib and trametinib
This study lets people who finished a prior dabrafenib/trametinib trial (sponsored by Novartis or former GSK) continue those medicines if the study doctor thinks it will help. It mainly focuses on ongoing treatment benefit rather than testing a new drug.
Scottsdale, ArizonaAges 18–100 - NCT03454035RecruitingPhase 1
Combination of two study drugs for advanced pancreatic and other solid tumors
This trial tests two drugs, ulixertinib and palbociclib, taken together to see if they can shrink tumors in patients with advanced pancreatic cancer, melanoma, or other solid tumors. It may be an option for people who have already tried standard treatments.
Chapel Hill, North CarolinaAges 18–99 - NCT07628634RecruitingEarly Phase 1
Testing a Low-Methionine Diet in Solid Tumor Patients
This early-stage study explores whether eating a diet low in methionine (a natural amino acid found in protein) might help people with advanced solid tumors. Researchers will track how this dietary change affects blood levels and may improve treatment outcomes alongside standard cancer care.
Orange, CaliforniaAges 18 years+ - NCT02830724RecruitingPhase 1/Phase 2
CAR T therapy using blood immune cells for CD70 cancers
This trial tests a personalized immune-cell treatment (CAR T) built from your own blood lymphocytes. It targets cancers that show a marker called CD70, aiming to slow or stop the cancer when other treatments didn’t work.
Bethesda, MarylandAges 18–72 - NCT02775643Recruiting
Study genes from children’s mole and melanoma samples
This study looks at the DNA and other biology from skin lesions (like melanoma or unusual pigmented moles) in children and teens. It aims to better understand what these tumors are and how they behave, using tissue samples collected during routine care.
Memphis, TennesseeAges Up to 18 years - NCT01772771Recruiting
Molecular testing to guide personalized cancer treatment plans
This trial uses special lab tests to look for tumor “molecular fingerprints” in your tumor or blood sample. The goal is to help your care team choose more personalized treatment options based on those results.
Houston, TexasAges Any age - NCT00722228RecruitingPhase 1/Phase 2
Cancer vaccine made from your cells or a donor
This early-phase trial tests a whole-cell cancer vaccine for people with certain metastatic cancers. It aims to help your immune system recognize and fight the cancer, especially when prior chemotherapy hasn’t worked.
JerusalemAges 18 years+ - NCT00923026Enrolling by invitation
Follow-up for adults previously treated in NCI surgery studies
This study asks people age 18+ who were previously treated on certain NCI Surgery Branch (NCI-SB) studies to come back for follow-up. It helps researchers understand how patients do over time after those earlier treatments, including some gene therapy studies.
Bethesda, MarylandAges 18 years+ - NCT00001823Recruiting
Surgery Branch Screening for Cancer Treatment Studies
This is a screening evaluation to see if you might be eligible for cancer treatment research studies at the National Cancer Institute's Surgery Branch. Doctors will review your medical history, imaging, and test results to determine which clinical trials might be right for you.
Bethesda, MarylandAges 18 years+ - NCT00068003Enrolling by invitation
Harvesting Cancer Cells for Experimental Treatment
This trial collects immune cells from cancer patients or healthy volunteers to develop new experimental cancer treatments. Researchers will take a sample of your tumor or blood cells, grow them in the lab, and study how to use them to fight your cancer.
Bethesda, MarylandAges 18 years+ - NCT07760012Recruiting
PET/CT scan for common solid tumors
This trial uses a new kind of PET/CT scan to take detailed pictures of solid tumors such as melanoma, liver, lung, breast, pancreatic, or ovarian cancer. The scan might help doctors find cancer more clearly.
Beijing, Beijing MunicipalityAges 18–75 - NCT07440290RecruitingPhase 2/Phase 3
Dabrafenib and trametinib for BRAF V600 cancers
This trial tests two targeted drugs (dabrafenib and trametinib) for patients whose cancer has a specific change in the BRAF gene called V600. These drugs work together to block signals that help the cancer grow. The trial is for children, teenagers, and adults with many types of cancer, except for a few common ones that already have approved treatments.
BelfastAges 1 year+ - NCT07636785RecruitingPhase 1/Phase 2
VMD-102 Drug Study for Advanced Cancers
This study tests a new drug called VMD-102 in patients with advanced liver cancer, melanoma, kidney cancer, lung cancer, or colon cancer that hasn't responded to standard treatments. The trial will help determine if VMD-102 is safe and effective at slowing or stopping cancer growth.
Scottsdale, ArizonaAges 18–75 - NCT07649681Recruiting
AI nutrition help for taste changes from cancer treatment
This study tests whether an AI-powered nutrition program can help people with taste changes caused by cancer therapy. You'll get personalized recipe suggestions and nutrition advice through an online portal to help you eat better during treatment.
Augsburg, BavariaAges 18 years+ - NCT07524114Recruiting
Blood test to find leftover cancer after treatment
This study uses a blood test to look for tiny bits of cancer DNA after you finish treatment. It may help doctors know if cancer is still there and guide next steps.
Toronto, OntarioAges 18 years+ - NCT07870265Recruiting
Blood test for detecting BRAF mutation in melanoma
This trial tests a new blood test to detect a specific gene change (BRAF V600E) in melanoma that has come back. The test uses a technology called CRISPR to find the mutation in a simple blood draw, which could help guide treatment without needing a tissue biopsy.
Brno, BrnoAges 18 years+ - NCT07788729Recruiting
Support program for cancer patients and their caregivers
This study tests a program that provides social support and short learning sessions to help cancer patients and their caregivers manage daily life. It aims to improve well-being and care for both patients and their support persons.
Augsburg, BavariaAges 18 years+ - NCT07808164Recruiting
Protein markers in solid tumors: a Vietnamese tissue study
This study looks at tissue samples from Vietnamese patients with solid tumors to understand the presence of certain proteins (ENPP1, cGAS, and FAP). The goal is to learn more about these tumors, which might help develop better treatments in the future.
Hanoi, HanoiAges 18 years+
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Common questions
- Are there clinical trials for melanoma?
- Yes. Clin2 currently lists 459 recruiting melanoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melanoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melanoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.