Clinical trials
Melanoma clinical trials
A serious form of skin cancer that develops in pigment-producing cells. We’re tracking 465 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07215182RecruitingPhase 2
New PET scan method for advanced melanoma
This trial tests a new type of PET scan that may find cancer more clearly and quickly than current scans. It's for people with advanced melanoma that has spread and cannot be removed by surgery.
Herlev, Capital RegionAges 18 years+ - NCT07223424RecruitingPhase 2
Patient preference study: shot vs infusion for immunotherapy
This study compares two ways to take immunotherapy drugs (nivolumab or pembrolizumab): as a shot under the skin (subcutaneous) versus an infusion into a vein (intravenous). It looks at which method patients prefer and is for people with certain advanced cancers where these drugs are already approved.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07224425RecruitingPhase 1
Study of a new drug for advanced solid tumors
This trial tests a new drug called BI 3810944 for people with advanced solid tumors that haven't responded to standard treatments. It aims to see if the drug is safe and helps shrink tumors.
Louisville, KentuckyAges 18 years+ - NCT07225036Recruiting
Low-dose liver radiation to boost immunotherapy
This trial tests whether adding a low dose of radiation to the liver can make standard immunotherapy work better for people with non-small cell lung cancer or melanoma that has spread to the liver.
Cincinnati, OhioAges 18 years+ - NCT07237594RecruitingPhase 1
IL-17 blocker to prevent immunotherapy side effects
This trial tests whether a drug called secukinumab (an IL-17 blocker) can prevent or reduce severe side effects when you restart immunotherapy for advanced melanoma. It's for people who've had immune-related side effects before and need to continue treatment.
Durham, North CarolinaAges 18 years+ - NCT07260591RecruitingPhase 1
VSV-02 for advanced solid tumors that need new options
This trial tests an experimental virus therapy called VSV-02 for people with advanced solid tumors that have not responded to standard treatments. The treatment is given directly into a tumor, aiming to attack cancer from the inside.
Xinxiang, HenanAges 18 years+ - NCT07277920Recruiting
Skin lesion study using special microscope and genetics
This study looks at skin spots that might be unusual moles or early melanoma using a special microscope that sees deep into the skin. It aims to match these microscope images with genetic information to better understand these spots.
Modena, MoAges 18 years+ - NCT07285044RecruitingPhase 2
Home cancer treatment program for Florida panhandle residents
This study tests whether people with certain cancers can safely receive their regular intravenous treatments at home instead of coming to the clinic. It aims to make treatment more convenient and improve satisfaction, especially for those living in the Florida Panhandle.
Jacksonville, FloridaAges 18 years+ - NCT07310758RecruitingPhase 2/Phase 3
Using ultrasound contrast to detect sentinel nodes in cancer
This trial tests whether contrast-enhanced ultrasound can help find sentinel lymph nodes (the first nodes cancer may spread to) in people with melanoma, breast, or head and neck cancer. It may reduce the need for a radioactive tracer injection.
Amsterdam, North HollandAges 18 years+ - NCT07318051Recruiting
Sample collection for cancer research study
This study collects blood and tumor tissue samples from patients with certain untreated cancers to help researchers develop and improve tests. You may be eligible if you have one of the listed cancer types and have not yet started treatment.
Austin, TexasAges 18 years+ - NCT05538130RecruitingPhase 1
Study medicine for BRAF-mutated advanced solid tumors
This Phase 1 trial studies how PF-07799544 works and what dose is safest in people with advanced cancer that has a specific genetic change called BRAF V600. You may receive it alone or with another treatment, depending on the tumor group, to see if it can treat the cancer.
Birmingham, AlabamaAges 16 years+ - NCT07349940Recruiting
Early skin cancer detection via telemedicine in primary care
This study tests if a telemedicine tool can help find skin tumors early. It may be a good fit if you have a suspicious spot and light skin that burns easily.
BrnoAges 50 years+ - NCT07371663RecruitingPhase 1/Phase 2
TCC1727 combination therapy for advanced solid tumors
This trial tests a new drug, TCC1727, combined with other treatments for people with advanced solid tumors that have stopped responding to standard therapy. It aims to see if these combinations can help shrink or control the cancer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07376707RecruitingPhase 1
Study of TGI-5 alone or with nivolumab for advanced solid tumors
This trial tests a new drug called TGI-5, either by itself or combined with another drug (nivolumab), for people with advanced cancer that hasn't responded to standard treatments. It's looking for patients with certain types of solid tumors, especially colorectal, melanoma, lung, or others that have stopped responding to therapy.
ShanghaiAges 18 years+ - NCT00001823Recruiting
Surgery Branch Screening for Cancer Treatment Studies
This is a screening evaluation to see if you might be eligible for cancer treatment research studies at the National Cancer Institute's Surgery Branch. Doctors will review your medical history, imaging, and test results to determine which clinical trials might be right for you.
Bethesda, MarylandAges 18 years+ - NCT01772771Recruiting
Molecular testing to guide personalized cancer treatment plans
This trial uses special lab tests to look for tumor “molecular fingerprints” in your tumor or blood sample. The goal is to help your care team choose more personalized treatment options based on those results.
Houston, TexasAges Any age - NCT00722228RecruitingPhase 1/Phase 2
Cancer vaccine made from your cells or a donor
This early-phase trial tests a whole-cell cancer vaccine for people with certain metastatic cancers. It aims to help your immune system recognize and fight the cancer, especially when prior chemotherapy hasn’t worked.
JerusalemAges 18 years+ - NCT02012699Recruiting
Cancer registry for people with or at risk of cancer
This trial collects health information and samples (a “cancer repository”) to help researchers study cancer and cancer risk. You may be able to join if you’ve had cancer before or if you’re at higher risk or have concerning findings.
Greenwood Village, ColoradoAges 19–110 - NCT02775643Recruiting
Study genes from children’s mole and melanoma samples
This study looks at the DNA and other biology from skin lesions (like melanoma or unusual pigmented moles) in children and teens. It aims to better understand what these tumors are and how they behave, using tissue samples collected during routine care.
Memphis, TennesseeAges Up to 18 years - NCT02906943Recruiting
Testing cancer tissue to guide targeted treatment choices
This trial studies advanced solid tumors by using stored tumor samples to look for molecular clues. The goal is to help doctors better choose cancer treatments that may work for your specific tumor.
Hamilton, OntarioAges 18 years+ - NCT02830724RecruitingPhase 1/Phase 2
CAR T therapy using blood immune cells for CD70 cancers
This trial tests a personalized immune-cell treatment (CAR T) built from your own blood lymphocytes. It targets cancers that show a marker called CD70, aiming to slow or stop the cancer when other treatments didn’t work.
Bethesda, MarylandAges 18–72 - NCT00923026Enrolling by invitation
Follow-up for adults previously treated in NCI surgery studies
This study asks people age 18+ who were previously treated on certain NCI Surgery Branch (NCI-SB) studies to come back for follow-up. It helps researchers understand how patients do over time after those earlier treatments, including some gene therapy studies.
Bethesda, MarylandAges 18 years+ - NCT00068003Enrolling by invitation
Harvesting Cancer Cells for Experimental Treatment
This trial collects immune cells from cancer patients or healthy volunteers to develop new experimental cancer treatments. Researchers will take a sample of your tumor or blood cells, grow them in the lab, and study how to use them to fight your cancer.
Bethesda, MarylandAges 18 years+ - NCT07403630Recruiting
Tumor chemogenomic profiler for cancer patients of all ages
This trial uses a new testing platform to analyze the genes and proteins in your tumor, aiming to find the most effective treatments for people with cancer that has come back, is not responding to treatment, or has spread. It is designed for both children and adults with any type of blood cancer or solid tumor.
Palermo, PalermoAges 1 year+
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Common questions
- Are there clinical trials for melanoma?
- Yes. Clin2 currently lists 465 recruiting melanoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a melanoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a melanoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.