Clinical trials
Mental Health Conditions clinical trials
Below are recruiting mental health conditions clinical trials, each written for real people, not researchers. We’re tracking 199 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04325958Recruiting
Test how cannabis affects driving in different age groups
This study looks at how smoked cannabis changes driving performance when compared across two age groups. It may help researchers understand safety risks and differences by age.
Toronto, OntarioAges 19–45 - NCT04396873RecruitingPhase 1
PET brain scan study of inflammation markers in neurodegeneration
This Phase 1 study tests a PET scan to measure inflammation-related changes in the brain using a medication called ketoprofen. It may help researchers understand which people with certain brain diseases could benefit from treatments aimed at inflammation.
Bethesda, MarylandAges 18–99 - NCT04447742Recruiting
Study of how healthy babies’ gut microbes develop from birth
This study follows pregnant people from about 20 weeks until delivery, to understand how gut microbes (tiny organisms in the intestines) develop in healthy babies. It may help researchers learn how early-life gut development affects health later on.
BernAges 18–45 - NCT04478838RecruitingPhase 4
Alternate-day antipsychotic dosing for schizophrenia
This trial looks at whether taking an antipsychotic every other day can keep symptoms controlled in adults with schizophrenia or another psychotic disorder. It may help some people avoid daily dosing, but it requires specific medication stability and screening checks.
Toronto, OntarioAges 18 years+ - NCT04569448RecruitingPhase 3
Brexpiprazole for bipolar depression that won’t improve
This Phase 3 study tests whether brexpiprazole can help treat bipolar depression that has not responded to previous treatments. It compares the study medicine to a placebo (inactive pill) for people with bipolar I or II depression.
Hamilton, OntarioAges 18–75 - NCT04631042Recruiting
Study how the brain relates to impulsivity and compulsivity
This study looks at how brain function and structure relate to impulsive and compulsive behaviors. It may help researchers understand what drives these behaviors and who may benefit from future mental health treatments.
Bethesda, MarylandAges 6–80 - NCT04798274Recruiting
Brain wiring study in autism using safe hearing tasks
This study looks at how a brain chemical related to calming signals (“GABA”) may affect how people process sounds in autism. The goal is to understand brain function during hearing tasks, which could help guide future treatments.
Bethesda, MarylandAges 11–25 - NCT04882839RecruitingPhase 2
Therapy with psilocybin for severe OCD symptoms
This Phase 2 study tests whether psilocybin-assisted psychotherapy can reduce symptoms in adults with severe, treatment-resistant OCD. It also focuses on safety and whether this approach is practical to run.
BeershebaAges 18–65 - NCT04895839Recruiting
Mental health coaching for men with prostate cancer
This study looks at what affects mental health while men with prostate cancer take part in a patient empowerment program. It may help you and others by testing a practical support approach delivered through email, texts, and online videos.
Ghent, East FlandersAges 18 years+ - NCT00018057RecruitingPhase 2
Brain study of pediatric anxiety disorders
This study looks at how the brain works in children and adults with anxiety disorders. It uses brain scans (fMRI) and other safe tests to understand anxiety better.
Bethesda, MarylandAges 8–65 - NCT05859204Enrolling by invitation
Exercise groups to improve mental health in hospital
This study tests whether joining structured exercise groups while you’re an inpatient in a psychiatric unit can improve mood, mental wellbeing, and overall comfort. It’s designed to be adjustable for different mobility needs and to be safe for participating patients.
Baltimore, MarylandAges 18 years+ - NCT05142735Recruiting
NAC for early psychosis risk symptoms
This trial studies whether NAC (a nutrient-like supplement) can reduce symptoms in people who are at high risk for developing psychosis. It may help by testing a safer, non-standard treatment approach for early warning signs.
Toronto, OntarioAges 16–35 - NCT05153369Recruiting
DBT-based care for youth at risk for bipolar disorder
This study tests a structured, “DBT-informed” care program for young people who either have bipolar disorder or are at family risk for it. It may help by offering closer, organized support aimed at preventing or reducing mood problems.
Toronto, OntarioAges 13–23 - NCT05153382Recruiting
Dialectical behavior therapy for youth at bipolar risk
This trial tests whether a structured therapy called dialectical behavior therapy (DBT) helps young people with bipolar disorder or at risk for it, especially with self-harm or risky behaviors. It may help by teaching coping skills and improving safety and emotional control.
Toronto, OntarioAges 13–23 - NCT05229666Recruiting
Study stress patterns in early pregnancy and preterm birth risk
This study looks at how stress shows up in the body during early pregnancy and whether it’s linked to preterm birth (birth before 37 weeks). You may be asked about your stress and health to help researchers understand who is at higher risk.
New York, New YorkAges 18 years+ - NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT05583747Recruiting
Brain stimulation therapy with guidance for treatment-resistant depression
This study tests a type of brain stimulation (guided iTBS) to improve depression when standard antidepressant treatments haven’t helped. It also checks that the treatment is safe for people who can meet the study and scan safety requirements.
Toronto, OntarioAges 18–65 - NCT05608434RecruitingPhase 1/Phase 2
VR training for improving attention in kids with ADHD
This study tests a virtual reality (VR) program meant to strengthen attention skills in children with ADHD. It compares different VR-based training options and looks at whether kids improve on attention-related thinking skills after the sessions.
Bethesda, MarylandAges 8–16 - NCT05627492Recruiting
DBT booster sessions for youth at bipolar risk
This study adds short “booster” sessions to Dialectical Behavior Therapy (DBT) for young people who already took part in a prior DBT study, including those with bipolar symptoms or strong family risk. It aims to see if extra DBT support helps mood and coping over time.
Toronto, OntarioAges 14–25 - NCT05666726Recruiting
Study how stress and body feelings affect choices
This study tests how changes in your internal body feelings (like heart rate and awareness of bodily sensations) and stress can affect decision-making and self-reflection. It may help researchers understand how thoughts, feelings, and body signals connect—especially in people vulnerable to anxiety or depression.
Bethesda, MarylandAges 18–55 - NCT05669703Recruiting
Tracking mood and activity patterns in bipolar disorder families
This study watches how a person’s mood and movement change over time, and how those patterns relate to bipolar disorder. It may help researchers better understand the condition in families and potentially improve future care.
Bethesda, MarylandAges 8–70 - NCT05748990Recruiting
Brain insulin differences in schizophrenia and thinking
This study tests whether unusual insulin action in the brain is linked to thinking problems and body/metabolic issues in schizophrenia. It may help researchers understand the cause and identify targets for future treatments.
Toronto, OntarioAges 17–45 - NCT05945277Recruiting
Peer support after a recent hospital stay
This trial tests a “critical time intervention” approach with peer support for people with a psychotic disorder soon after leaving psychiatric inpatient care. It may help by providing practical support during a high-risk period for relapse and distress.
LisbonAges 18–65 - NCT05973110Recruiting
Virtual reality training to improve thinking in psychosis
This trial tests whether a virtual reality program can help people living with psychosis improve thinking and daily functioning. It may help if your symptoms are currently stable and you can safely use the VR equipment.
Ottawa, OntarioAges 18–60
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Common questions
- Are there clinical trials for mental health conditions?
- Yes. Clin2 currently lists 199 recruiting mental health conditions studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health conditions trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health conditions trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.