Do antipsychotics block insulin action in the brain?
Treatments studied
Part of Brain & nervous system, Hormones & metabolism clinical trials.
This study tests whether a single dose of a common antipsychotic medication affects how the brain responds to insulin, which could help explain weight gain and metabolic side effects. Healthy young adults will receive either the antipsychotic or a placebo, then have their brain activity measured with an MRI.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 35 years old.
- Your body mass index (BMI) is between 18.5 and 24.9 (normal weight range).
- You have no current or past psychiatric illness or substance use disorder.
- You do not have diabetes or prediabetes, and have no family history of diabetes in a parent or sibling.
- You are not pregnant, breastfeeding, or using hormonal birth control or hormone treatments.
- You have no metal implants, pacemaker, or other MRI contraindications, and are not claustrophobic.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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