Do antipsychotics block insulin action in the brain?
Treatments studied
Part of Brain & nervous system, Hormones & metabolism, Mental health clinical trials.
This study tests whether a single dose of a common antipsychotic medication affects how the brain responds to insulin, which could help explain weight gain and metabolic side effects. Healthy young adults will receive either the antipsychotic or a placebo, then have their brain activity measured with an MRI.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 35 years old.
- Your body mass index (BMI) is between 18.5 and 24.9 (normal weight range).
- You have no current or past psychiatric illness or substance use disorder.
- You do not have diabetes or prediabetes, and have no family history of diabetes in a parent or sibling.
- You are not pregnant, breastfeeding, or using hormonal birth control or hormone treatments.
- You have no metal implants, pacemaker, or other MRI contraindications, and are not claustrophobic.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether metformin can help adults with intellectual disability who gained weight from long-term antipsychotic medicines. If you qualify, you may be assigned metformin to improve weight and related health measures.
This study tests whether a GLP-1 receptor agonist (a type of diabetes medicine) changes how the brain responds to insulin in people with different body sizes. It may help understand if this drug can improve brain function related to insulin.
This study looks at how two brain chemicals, dopamine and insulin, work in people with schizophrenia compared to healthy volunteers. It uses MRI scans and other tests to understand these differences, which might lead to better treatments in the future.
This study looks at how a medication that mimics a natural gut hormone affects brain activity related to appetite in people with healthy weight or obesity. It may help researchers find new ways to treat obesity.
This study looks at how insulin resistance in the brain affects brain health. If you have type 1 or type 2 diabetes and are between 50 and 80 years old, you may be able to join to help researchers understand brain changes.
This study uses PET and MRI scans to see how antipsychotic medications affect the brain's dopamine system in people with schizophrenia, compared to healthy individuals. It may help understand if these medications cause changes that lead to worsening symptoms over time.
Hear when a new Brain Insulin Sensitivity trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.