Clinical trials
Mental Health Disorder clinical trials
Below are recruiting mental health disorder clinical trials, each written for real people, not researchers. We’re tracking 522 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04569448RecruitingPhase 3
Brexpiprazole for bipolar depression that won’t improve
This Phase 3 study tests whether brexpiprazole can help treat bipolar depression that has not responded to previous treatments. It compares the study medicine to a placebo (inactive pill) for people with bipolar I or II depression.
Hamilton, OntarioAges 18–75 - NCT05012072Recruiting
Lifestyle coaching to lower pregnancy stress and risk
This study tests a lifestyle coaching program to help reduce stress and improve emotional wellbeing during pregnancy. It may help lower risks for the baby by supporting healthier daily routines and mental health.
Webster, TexasAges 18–45 - NCT05142735Recruiting
NAC for early psychosis risk symptoms
This trial studies whether NAC (a nutrient-like supplement) can reduce symptoms in people who are at high risk for developing psychosis. It may help by testing a safer, non-standard treatment approach for early warning signs.
Toronto, OntarioAges 16–35 - NCT05363397RecruitingPhase 2
Adjunctive TBO-309 added to stroke clot removal treatment safety
This Phase 2 trial studies whether adding TBO-309 to standard emergency treatment for acute ischemic stroke is safe and tolerable. It may help researchers see if the added drug can be given without causing excessive side effects alongside clot-busting and/or clot-removal procedures.
Camperdown, New South WalesAges 18 years+ - NCT05435300Recruiting
tDCS study using brain scans in schizophrenia
This trial tests whether a non-invasive brain stimulation approach (tDCS) changes brain connections in people with schizophrenia. It also uses specialized scans to look for changes in the brain that could help explain how treatment works.
Toronto, OntarioAges 18 years+ - NCT05442957Recruiting
BRIGHT program after head and neck cancer treatment
This trial tests a “renewed image” program (BRIGHT) compared with another option (AC) after you’ve finished treatment for certain head and neck cancers. It may help you with emotional well-being and adjustment after cancer.
Detroit, MichiganAges 18 years+ - NCT05490745Recruiting
Parent-focused therapy to improve positive parenting in young children
This study tests a parenting-focused psychological program designed to support how parents understand and respond to their child’s feelings, especially after stressful events. It may help families improve parenting and child mental well-being for children ages 3–6 who are showing emotional or behavior concerns.
Braga, Braga DistrictAges 3–6 - NCT05603000Recruiting
Emotion-focused therapy for parents of anxious or struggling children
This study tests an emotion-focused family therapy program for parents of children (ages 7–15) who are dealing with anxiety, depression, or behavior challenges. It may help families improve how emotions are understood and managed through parent participation and home life support.
Guelph, OntarioAges 7–15 - NCT05666726Recruiting
Study how stress and body feelings affect choices
This study tests how changes in your internal body feelings (like heart rate and awareness of bodily sensations) and stress can affect decision-making and self-reflection. It may help researchers understand how thoughts, feelings, and body signals connect—especially in people vulnerable to anxiety or depression.
Bethesda, MarylandAges 18–55 - NCT05744479RecruitingPhase 4
Metformin to reduce weight gain from antipsychotic medicines
This trial tests whether metformin can help adults with intellectual disability who gained weight from long-term antipsychotic medicines. If you qualify, you may be assigned metformin to improve weight and related health measures.
Toronto, OntarioAges 16–65 - NCT05748990Recruiting
Brain insulin differences in schizophrenia and thinking
This study tests whether unusual insulin action in the brain is linked to thinking problems and body/metabolic issues in schizophrenia. It may help researchers understand the cause and identify targets for future treatments.
Toronto, OntarioAges 17–45 - NCT05773898Recruiting
Talking with families to understand suicide in overseas territories
This study asks people close to someone who died by suicide to share information about their life, including childhood. Researchers use these interviews to better understand suicide behaviors and improve prevention efforts.
Fort-de-France, FranceAges 18 years+ - NCT06024473Recruiting
Brain stimulation and virtual reality for memory loss
This study uses a combination of brain stimulation (rTMS) and virtual reality exercises to help improve memory and thinking. It is for people aged 55 and older who have Mild Cognitive Impairment (MCI), a condition that can affect memory but is not dementia.
Little Rock, ArkansasAges 55 years+ - NCT06032377Recruiting
Online therapy for sleep and brain health in older adults
This study tests an online talk therapy program (CBT) to help older adults with both sleep troubles and mild memory or thinking concerns. It's done from home, and aims to improve sleep and brain health.
Ottawa, OntarioAges 60–99 - NCT06047301Recruiting
Pathways: A hope program for advanced lung cancer patients
This study tests a program called 'Pathways' that helps people with advanced lung cancer set personal goals, manage mental health, and improve quality of life. It's for those who are already receiving IV cancer treatment and are feeling some distress.
Lexington, KentuckyAges 18 years+ - NCT06247306Recruiting
Neurofeedback and stress in alcohol use
This study uses a brain-training technique called neurofeedback to help understand how stress and drinking are linked. You would use your smartphone to participate, and the goal is to find better ways to manage alcohol use.
Mannheim, Baden-WurttembergAges 18–65 - NCT06346028RecruitingPhase 4
TMS for quitting smoking
This study tests whether a brain stimulation therapy called transcranial magnetic stimulation (TMS) can help people quit smoking. It is for adults who smoke daily and are willing to try TMS as a treatment.
Toronto, OntarioAges 18–70 - NCT06350201Recruiting
Online CBT Based on Symptom Groups
This study uses a computer program to group symptoms and then offers an online cognitive behavioral therapy (CBT) program. It aims to help people who feel depressed or anxious by tailoring treatment based on their specific symptom patterns.
WuhanAges 18–64 - NCT06351514RecruitingPhase 3
Accelerated brain stimulation for negative symptoms of schizophrenia
This trial tests a faster form of brain stimulation called accelerated intermittent theta burst stimulation to help with persistent negative symptoms of schizophrenia. Negative symptoms include things like lack of motivation, reduced emotion, or social withdrawal.
SingaporeAges 21–65 - NCT06435208Recruiting
Gum cleaning for mental health in teeth grinders with gum disease
This study tests whether a deep gum cleaning procedure (subgingival instrumentation) can reduce stress and improve mental health in people who grind their teeth and have gum disease. It aims to see if treating the gums can also help with psychological distress.
Rohtak, HaryanaAges 30–50 - NCT06438276Recruiting
Mental health support for teens through school services
This study tests whether psychiatric outreach nurses can help teenagers aged 12-16 who are dealing with mood issues, anxiety, obsessive-compulsive or eating disorder symptoms, or mild self-harm. The goal is to see if this extra support improves their mental health compared to the usual school services.
Kuopio, Northern SavoniaAges 12–16 - NCT06456983Recruiting
Maintenance ECT for hard-to-treat schizophrenia
This trial tests if regular electroconvulsive therapy (ECT) can help people whose schizophrenia has not improved with clozapine or who cannot take clozapine. Researchers will see if maintenance ECT helps prevent symptoms from returning.
AachenAges 18–75 - NCT06493825Recruiting
Mindfulness app for kids with severe tinnitus or misophonia
This trial tests whether a virtual reality mindfulness app can help children aged 10–18 with severe tinnitus or misophonia feel better mentally. It compares the mindfulness app to a placebo (sham) version.
Aurora, ColoradoAges 10–18 - NCT06505226Recruiting
Music mindfulness study for anxiety and depression
This study tests a music-based mindfulness program to help people with anxiety or depression. It compares the program to a wait list to see if it eases symptoms.
New Haven, ConnecticutAges 18–65
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Common questions
- Are there clinical trials for mental health disorder?
- Yes. Clin2 currently lists 522 recruiting mental health disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mental health disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mental health disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.