Clinical trials
Middle Aged clinical trials
Below are recruiting middle aged clinical trials, each written for real people, not researchers. We’re tracking 39 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05149742Recruiting
Study of hearing loss and thinking skills in midlife adults
This study looks at how severe hearing loss affects thinking and memory in adults aged 45–64. Researchers will compare people with significant hearing loss to people with normal hearing who are similar in age, sex, and education.
ParisAges 45–64 - NCT07171255Recruiting
App-based exercise program for rural adults
This trial tests if a smartphone app can help adults aged 40-85 who are not very active, live in rural parts of Kansas or Nebraska, and are at risk for health problems. The goal is to see if using the app helps them exercise more and stick with it.
Emporia, KansasAges 40–85 - NCT07231783Recruiting
Urolithin A supplement for muscle strength in adults 40–65
This trial tests whether a daily supplement called Urolithin A (Mitopure®) can improve muscle strength in healthy middle-aged adults who are not very active. Researchers will measure changes in strength and fitness over several weeks.
CorkAges 40–65 - NCT06592859Recruiting
NMN supplement study for healthy middle-aged and older adults
This study tests if nicotinamide mononucleotide (NMN), a natural supplement, can help middle-aged and older adults stay healthy. It aims to see if NMN can slow aging-related changes in healthy people between 40-70 years old.
Quzhou, ZhejiangAges 39–70 - NCT06666660Recruiting
Multivitamin study for middle-aged adults
This trial tests whether taking a daily multivitamin and mineral supplement can slow or reverse biological aging in healthy middle-aged adults. It involves blood tests, wearing an OURA ring, and using a study app.
Singapore, SingaporeAges 40–60 - NCT06794255Recruiting
Vitamin C for healthy aging in middle-aged adults
This study looks at whether vitamin C can help support healthy aging in middle-aged and older adults. It will compare taking vitamin C to a placebo (a dummy pill) to see if it improves overall health.
Nanchang, JiangxiAges 18–70 - NCT03821623RecruitingPhase 2
Vitamin-like nicotinamide riboside for higher blood pressure
This trial tests whether nicotinamide riboside can improve elevated blood pressure and blood vessel stiffness in middle-aged and older adults. You may be randomly assigned to take the study medicine or not, and the team will check your heart/blood vessel measurements over time.
Boulder, ColoradoAges 50 years+ - NCT07757529Recruiting
Sage extract for thinking and memory in middle-aged adults
This study tests whether a daily sage extract supplement can improve thinking, focus, and memory in healthy middle-aged adults. If it works, it could offer a natural way to support brain health.
College Station, TexasAges 40–60 - NCT05183230Recruiting
Mobile program to help prevent suicide after hospital stay
This trial tests a phone-based (mobile) support program for middle-aged and older adults after a recent hospital stay for suicidal thoughts or an attempt. The goal is to reduce the chance of another suicidal crisis by providing structured support after discharge.
New York, New YorkAges 50–90 - NCT07453823Recruiting
Synbiotic for gut health in overweight adults
This trial tests a combination supplement (a synbiotic) to see if it can improve gut function and gut bacteria in middle-aged and older adults who are overweight and have constipation. If eligible, you take the supplement daily and report how your digestion feels.
Cork, BlackpoolAges 50–70 - NCT06012227Recruiting
Cheese and metabolic health in middle age
This study looks at how eating cheese affects your body's ability to use energy (metabolic flexibility). It is for healthy middle-aged adults who are not overweight and do not have metabolic conditions like diabetes.
Monserrato, CagliariAges 45–65 - NCT07085663Recruiting
Exergame brain and body training for adults 50-60 in China
This study tests whether combining exercise video games with memory and thinking tasks can help middle-aged adults who feel their memory is getting worse. It aims to see if this type of training can improve both physical and mental function.
Chengdu, SichuanAges 50–60 - NCT06896708Recruiting
Intensive cholesterol treatment for heart plaque in younger adults
This trial tests whether higher doses of cholesterol-lowering medication (statins) can slow down plaque buildup in the heart arteries of younger and middle-aged adults with stable chest pain. It may help prevent heart attacks and the need for procedures like stents.
Chongqing, Chongqing MunicipalityAges 18–60 - NCT06907329Recruiting
NMN supplement trial for middle-aged adults with metabolic issues
This trial tests whether a sustained-release nicotinamide mononucleotide (NMN) supplement can improve immune aging and metabolism in people aged 50-70 who are overweight or have fatty liver, pre-diabetes, or mild type 2 diabetes.
ShanghaiAges 50–70 - NCT07064551Recruiting
Combining medical and community support for depression
This study tests a new way of combining medical care with community support for middle-aged and older adults who have depression and are waiting for mental health services. The goal is to see if this team approach can help improve mood and well-being while you wait.
Hong KongAges 45 years+ - NCT07265726Enrolling by invitation
Oral health education for older adults: a study on intentionality
This trial tests a program to help older adults improve their oral health through education and intentional practice. It may help you learn to take better care of your teeth and gums.
New Taipei City, New Taipei CityAges 40–100 - NCT07388043Recruiting
AP-Brain for memory in older adults with memory concerns
This trial tests a supplement called AP-Brain to see if it helps with memory and thinking in healthy middle-aged and older adults who notice memory problems. You would take different doses of the supplement or a placebo for several weeks and complete memory tests.
London, OntarioAges 40–79 - NCT07515287Enrolling by invitation
Pilates for Back Pain Recovery in Middle-Aged Women
This study tests whether Pilates exercises can help women aged 45–60 with chronic lower back disc problems improve their balance, leg strength, and body awareness. Pilates focuses on core stability and controlled movement, which may help restore function lost due to the disc herniation.
Kahramanmaraş, onikişubatAges 45–60 - NCT07740967Recruiting
Collagen and omega supplements for middle-aged women
This study tests whether daily collagen and omega-3 supplements can improve health in healthy middle-aged women. You would take the supplements for a period and have your health measured.
LoughboroughAges 35–65 - NCT07476222Recruiting
Predicting testosterone decline in middle-aged men
This study looks at why testosterone levels drop in men aged 35-59. It may help identify early signs and ways to prevent it.
AndijanAges 35–59 - NCT07729930Recruiting
Creatine supplement study for healthy middle-aged women
This study is testing a creatine supplement (a substance that may help with energy and muscle function) in healthy middle-aged women. You may join if you are between 35 and 65, a non-smoker, and have a certain activity level.
LoughboroughAges 35–65 - NCT05754151Recruiting
Mobile therapy for anxiety and depression in adults 40+
This trial tests whether a phone or tablet version of cognitive behavioral therapy (CBT) can help people ages 40 and older with anxiety or depression. It may help you manage symptoms with skills you can use between sessions.
New York, New YorkAges 40 years+ - NCT05841667Recruiting
How your CES1 genes affect remimazolam during anesthesia
This study looks at whether a person’s genetic type (CES1) changes how the anesthesia medicine remimazolam works and how much it affects the depth of sleep. It may help doctors choose safer, better-matched anesthesia for future patients having elective surgery.
SeoulAges 19–70 - NCT06164262Recruiting
Dementia risk study for people with small vessel disease
This study tracks people ages 30 to 60 who have signs of small vessel disease on brain MRI. It aims to understand the risk of dementia over the next 10 years, so you can get early monitoring and care.
Hangzhou, ZhejiangAges 30–60
Hear when a new Middle Aged trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for middle aged?
- Yes. Clin2 currently lists 39 recruiting middle aged studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a middle aged trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a middle aged trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.