Clinical trials
Middle Aged clinical trials
Below are recruiting middle aged clinical trials, each written for real people, not researchers. We’re tracking 37 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05149742Recruiting
Study of hearing loss and thinking skills in midlife adults
This study looks at how severe hearing loss affects thinking and memory in adults aged 45–64. Researchers will compare people with significant hearing loss to people with normal hearing who are similar in age, sex, and education.
ParisAges 45–64 - NCT07231783Recruiting
Urolithin A supplement for muscle strength in adults 40–65
This trial tests whether a daily supplement called Urolithin A (Mitopure®) can improve muscle strength in healthy middle-aged adults who are not very active. Researchers will measure changes in strength and fitness over several weeks.
CorkAges 40–65 - NCT07171255Recruiting
App-based exercise program for rural adults
This trial tests if a smartphone app can help adults aged 40-85 who are not very active, live in rural parts of Kansas or Nebraska, and are at risk for health problems. The goal is to see if using the app helps them exercise more and stick with it.
Emporia, KansasAges 40–85 - NCT06666660Recruiting
Multivitamin study for middle-aged adults
This trial tests whether taking a daily multivitamin and mineral supplement can slow or reverse biological aging in healthy middle-aged adults. It involves blood tests, wearing an OURA ring, and using a study app.
Singapore, SingaporeAges 40–60 - NCT06794255Recruiting
Vitamin C for healthy aging in middle-aged adults
This study looks at whether vitamin C can help support healthy aging in middle-aged and older adults. It will compare taking vitamin C to a placebo (a dummy pill) to see if it improves overall health.
Nanchang, JiangxiAges 18–70 - NCT06592859Recruiting
NMN supplement study for healthy middle-aged and older adults
This study tests if nicotinamide mononucleotide (NMN), a natural supplement, can help middle-aged and older adults stay healthy. It aims to see if NMN can slow aging-related changes in healthy people between 40-70 years old.
Quzhou, ZhejiangAges 39–70 - NCT06073990Enrolling by invitation
Insomnia help for adults 50 and older
This trial tests a short talk therapy that helps improve sleep without medication. It focuses on older adults who have had trouble sleeping for at least 3 months.
Tainan, TaiwanAges 50 years+ - NCT06012227Recruiting
Cheese and metabolic health in middle age
This study looks at how eating cheese affects your body's ability to use energy (metabolic flexibility). It is for healthy middle-aged adults who are not overweight and do not have metabolic conditions like diabetes.
Monserrato, CagliariAges 45–65 - NCT06217029Recruiting
MRI Study of Neck Pain in Adults
This study uses MRI scans to look at how neck pain affects young and middle-aged adults. It helps doctors understand the condition better and may guide future treatments.
Xi'an, ShaanxiAges 18–50 - NCT07820800Recruiting
Personalized digital health guidance for middle-aged adults
This study tests whether a digital health app can help middle-aged adults based on their personal metabolic risk. It aims to prevent diseases by providing tailored guidance.
SavonlinnaAges 45–55 - NCT07775833Recruiting
Mushroom supplement to slow memory decline in at-risk adults
This trial tests whether eating mushrooms regularly can help prevent memory loss in people who are at higher risk for Alzheimer's disease but do not have dementia. If you are between 45 and 80, have some memory concerns, and currently eat mushrooms rarely, this study may be a good fit.
SingaporeAges 45–80 - NCT07757529Recruiting
Sage extract for thinking and memory in middle-aged adults
This study tests whether a daily sage extract supplement can improve thinking, focus, and memory in healthy middle-aged adults. If it works, it could offer a natural way to support brain health.
College Station, TexasAges 40–60 - NCT07740967Recruiting
Collagen and omega supplements for middle-aged women
This study tests whether daily collagen and omega-3 supplements can improve health in healthy middle-aged women. You would take the supplements for a period and have your health measured.
LoughboroughAges 35–65 - NCT07729930Recruiting
Creatine supplement study for healthy middle-aged women
This study is testing a creatine supplement (a substance that may help with energy and muscle function) in healthy middle-aged women. You may join if you are between 35 and 65, a non-smoker, and have a certain activity level.
LoughboroughAges 35–65 - NCT05841667Recruiting
How your CES1 genes affect remimazolam during anesthesia
This study looks at whether a person’s genetic type (CES1) changes how the anesthesia medicine remimazolam works and how much it affects the depth of sleep. It may help doctors choose safer, better-matched anesthesia for future patients having elective surgery.
SeoulAges 19–70 - NCT07686601Enrolling by invitation
Shockwave therapy for belly fat
This study tests whether a sound-wave device (shockwave therapy) applied to your belly can help shrink fat and improve body measurements. It is for adults who have stubborn belly fat and are otherwise healthy.
Shibīn al Kawm, MenofyiaAges 18 years+ - NCT07637487Recruiting
Tocotrienol supplement study for healthy middle-aged adults
This study tests whether tocotrienol, a form of vitamin E from palm oil, can help reduce aging-related cell damage in people aged 35–64. Researchers will check if this supplement is safe and effective for generally healthy adults.
Kuala Lumpur, Kuala LumpurAges 35–50 - NCT06717828Recruiting
Tai Chi for fatty liver in older adults
This trial tests whether Tai Chi, a gentle exercise, can improve fatty liver disease in middle-aged and older adults who are overweight. If you are between 40 and 75 and have metabolic fatty liver, you might be able to join.
Fuzhou, FujianAges 40–75 - NCT07515287Enrolling by invitation
Pilates for Back Pain Recovery in Middle-Aged Women
This study tests whether Pilates exercises can help women aged 45–60 with chronic lower back disc problems improve their balance, leg strength, and body awareness. Pilates focuses on core stability and controlled movement, which may help restore function lost due to the disc herniation.
Kahramanmaraş, onikişubatAges 45–60 - NCT07497698Recruiting
Saffron supplement for better sleep in adults
This study tests whether taking a saffron extract supplement can help improve sleep in middle-aged adults with mild to moderate sleep troubles. You would take a daily supplement for a few weeks and report how well you sleep.
Granada, GranadaAges 18–65 - NCT07480109Recruiting
More protein while on weight-loss meds in women
This study tests if eating extra protein helps middle-aged women with overweight or obesity who are just starting a GLP-1 medication. You would eat extra protein for a few weeks while staying active as usual.
Austin, TexasAges 30–60 - NCT07476222Recruiting
Predicting testosterone decline in middle-aged men
This study looks at why testosterone levels drop in men aged 35-59. It may help identify early signs and ways to prevent it.
AndijanAges 35–59 - NCT07453823Recruiting
Synbiotic for gut health in overweight adults
This trial tests a combination supplement (a synbiotic) to see if it can improve gut function and gut bacteria in middle-aged and older adults who are overweight and have constipation. If eligible, you take the supplement daily and report how your digestion feels.
Cork, BlackpoolAges 50–70 - NCT07398495Recruiting
Exercise program for diabetes and muscle loss
This study tests whether a special exercise program can help middle-aged and older adults who have both type 2 diabetes and muscle loss. It aims to improve muscle strength, balance, and overall health.
Taichung, TaiwanAges 45–85
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Common questions
- Are there clinical trials for middle aged?
- Yes. Clin2 currently lists 37 recruiting middle aged studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a middle aged trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a middle aged trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.