Clinical trials
Mood clinical trials
Below are recruiting mood clinical trials, each written for real people, not researchers. We’re tracking 145 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05197738Recruiting
Study using a sleep health app to improve sleep
This study tests a “sleep health” app (REFRESH) to see how it may help people track and improve sleep. You may be eligible if you’re an adult in the U.S. who can use the app on your own phone.
La Jolla, CaliforniaAges 18 years+ - NCT07812870Recruiting
Behavioral activation for teens with autism and depression
This study tests a therapy called behavioral activation, which helps people engage in positive activities to improve mood, for autistic teens with mild intellectual disabilities who also have depression. It aims to see if this approach can reduce depressive symptoms and improve well-being.
Stony Brook, New YorkAges 12–17 - NCT07783633Enrolling by invitation
Digital tools for mood disorders study
This study looks at whether using digital tools, like apps or online programs, can help people with mood disorders like depression or bipolar disorder. It aims to find markers that show who might benefit most from these tools.
Toronto, OntarioAges 16 years+ - NCT07771322Recruiting
Online therapy for Asian American adults
This study tests a digital mental health platform designed for Asian Americans. You'll get online therapy sessions, and the goal is to see if the platform helps improve your mental health.
Brooklyn, New YorkAges 18–90 - NCT07774481Recruiting
Anxiety skills study for Ohio residents
This study tests an anxiety management program that you can use on your smartphone. It aims to help reduce anxiety symptoms and improve daily functioning.
Columbus, OhioAges 18 years+ - NCT06005194Recruiting
Exercise therapy via telehealth for depression after brain injury
This study tests whether an exercise program delivered through video calls can help treat major depression in people who have had a traumatic brain injury. If you are at least one year past your injury and have symptoms of depression, you may be able to join.
Seattle, WashingtonAges 18–64 - NCT07756658Recruiting
Tyrosol and creatine for exercise and thinking
This trial tests whether taking two supplements, tyrosol and creatine, can improve how well you exercise and think. If you join, you'll take these supplements while keeping your usual workout and diet, and the researchers will measure changes in your performance and memory.
Tampa, FloridaAges 20–55 - NCT07740135Enrolling by invitation
Daily multivitamin effects on mood and well-being
This study tests whether taking a daily multivitamin (Centrum) for a period can improve mood and overall well-being. It uses a special EEG headset to measure brain activity, and participation involves filling out questionnaires and a facility visit.
Hamilton, OntarioAges 40–60 - NCT07719517Recruiting
Morning activities to boost mood after stroke
This study tests if doing simple, guided activities in the morning can help improve your mood after a stroke. If you often feel down and have trouble getting going in the morning, this program might offer a way to feel better.
Hong KongAges 18 years+ - NCT06363981Recruiting
Brain stimulation for depression, sleep and memory problems
This study tests a non-invasive brain stimulation treatment (called rTMS) to help with depression, sleep problems, and memory or concentration issues. It's designed for people with moderate to severe depression who also have trouble sleeping and thinking clearly.
KrakowAges 18–65 - NCT07689526Recruiting
BabaCare: Testing a Care Copilot
This study tests a smartphone app called Baba that helps people who live alone and feel exhausted. It aims to see if the app can make daily life easier and reduce feelings of burnout.
Baltimore, MarylandAges 65 years+ - NCT07685925Enrolling by invitation
Health study for 2026 medical interns
This study tracks medical interns during their first year using a smartphone app. It aims to understand how internship affects health.
Ann Arbor, MichiganAges 18 years+ - NCT07685262Recruiting
Bright light therapy for better daytime function in students
This trial tests if morning bright light therapy can help university students feel more awake and function better during the day. You may be eligible if you live in shared student housing and don't have a diagnosed sleep problem.
Hung HomAges 18 years+ - NCT07676110Recruiting
Music and nature visuals for emotional well-being
This study tests if listening to enhanced music and watching natural visuals can improve your emotional health. You'll use your own headphones and a smartphone or tablet to take part.
Fort Collins, ColoradoAges 13 years+ - NCT07680153RecruitingPhase 4
Brain stimulation for bipolar depression
This study tests a non-invasive brain stimulation technique to see if it can improve mood in people with bipolar disorder who are currently experiencing depression. It aims to understand how the brain's mood circuits work.
New York, New YorkAges 18–70 - NCT05058872RecruitingPhase 4
Study links birth-control hormones to brain reward responses
This Phase 4 study uses brain imaging and daily questions to understand how contraceptive hormones may affect reward and brain signals. You may be able to join if you meet the health, birth-control, and safety requirements for MRI.
Aurora, ColoradoAges 18 years+ - NCT06398496Recruiting
Exercise, gut health, mood in depression
This trial studies whether a 12-week exercise program can improve gut bacteria, mood, and thinking in people with depression. It may help if you are looking for a non-medication way to support your mental health.
Cork, Cork CountyAges 18–59 - NCT07626944Recruiting
Music and Sound Therapy for Dementia Behaviors
This study tests whether special music and sound patterns can help reduce difficult behaviors and improve mood in people with dementia living in assisted care. Researchers will play these sounds to you and track any changes in how you feel and behave.
Denver, ColoradoAges 55–95 - NCT06336590Recruiting
Does changing exercise time improve sleep in college students?
This study looks at whether changing the time you exercise (from evening to morning) can help college students sleep better. You'll wear a small wrist monitor to track your sleep and activity, and either keep your usual evening exercise routine or switch to morning exercise for 4 weeks.
New Brunswick, New JerseyAges 18–23 - NCT04478305RecruitingPhase 1
Duavive trial for mood and anxiety in midlife women
This Phase 1 study tests Duavive’s effects on mood and anxiety symptoms in women going through perimenopause or early menopause. It may help clarify whether this treatment can reduce depression and/or anxiety symptoms in midlife.
Hamilton, OntarioAges 45–60 - NCT07600840Enrolling by invitation
Smart Watch and App for Understanding and Treating Sleep Problems
This study tests a combination of a wearable smart watch, brain-wave monitor (EEG), and smartphone app designed to help understand your sleep problems and emotions. The goal is to develop a digital tool that tracks your sleep patterns and mood to improve insomnia treatment.
Taipei, TaipeiAges 18–64 - NCT07599930Recruiting
Novel Snack for Perimenopausal Symptoms and Wellness
This study tests whether a specially designed snack can help reduce hot flashes, night sweats, mood changes, and other symptoms that happen during perimenopause (the years leading up to menopause). You'll eat the snack regularly and answer questions about how you feel.
London, LondonAges 40–55 - NCT06716554Recruiting
Shatavari for menopausal symptoms in women
This study tests whether a natural herb called Shatavari can help with menopausal symptoms like hot flashes, sleep problems, and mood changes. It compares Shatavari to a placebo (a pill with no active ingredient) to see if it is safe and effective.
San Francisco, CaliforniaAges 45–55 - NCT07572526Recruiting
Brain Stimulation to Improve Sleep and Mood in Depression
This study tests a non-invasive brain stimulation technique called tDCS (transcranial direct current stimulation) to see if improving sleep can help reduce depression symptoms. You'll do short stimulation sessions at home and track your sleep and mood.
New York, New YorkAges 18–65
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Common questions
- Are there clinical trials for mood?
- Yes. Clin2 currently lists 145 recruiting mood studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mood trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mood trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.