Clinical trials
Mood clinical trials
Below are recruiting mood clinical trials, each written for real people, not researchers. We’re tracking 149 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05985811Recruiting
Ketamine for chronic pain and mood in adults
This trial tests if ketamine injections can improve both pain and mood in adults with chronic pain who also have a mood disorder and trouble sleeping. It may help if you already get regular ketamine treatments.
Surrey, British ColumbiaAges 20–99 - NCT03059069RecruitingPhase 4
Gliatamin for low mood in adults with type 2 diabetes
This trial tests whether gliatamin (choline alphoscerate) can improve depressive mood in people with type 2 diabetes. You may be eligible if your diabetes is fairly controlled and your depression symptoms are in a mild-to-moderate range.
SeoulAges 50 years+ - NCT07281729Enrolling by invitation
Suicide risk factors study for mood disorders
This study looks at why some people with mood disorders (like depression or bipolar disorder) think about or attempt suicide. By finding the risk factors, doctors hope to better prevent suicide. The study involves filling out questionnaires.
Shanghai, Shanghai MunicipalityAges 16–60 - NCT06158880Recruiting
Alcohol and men's sexual risk behaviors
This study looks at how alcohol affects men's decisions about sex, especially risky behaviors like not using condoms. If you join, you may help researchers understand how to reduce HIV and STI risk.
Phoenix, ArizonaAges 21–30 - NCT07610135RecruitingPhase 1/Phase 2
Psilocybin with or without pimavanserin pretreatment
This trial tests whether taking pimavanserin before psilocybin changes the drug's effects in healthy volunteers who have never used psychedelics. It aims to understand how to make psychedelic therapy safer and more predictable.
Baltimore, MarylandAges 21–65 - NCT07017023RecruitingEarly Phase 1
Blood pressure meds and activity scheduling for low mood
This study tests if taking a blood pressure medication (losartan) combined with a simple scheduling of pleasant activities can help improve low mood. It aims to see if these treatments work better together.
Oxford, OxfordshireAges 18–65 - NCT06531863RecruitingEarly Phase 1
Curcumin and green tea supplement for mood improvement
This study tests whether taking curcumin (found in turmeric) and EGCG (found in green tea) can improve mood and increase a brain protein called BDNF, which may help with depression. It is for adults ages 18 to 50 with mild to moderate depression symptoms.
Auburn, AlabamaAges 18–50 - NCT07717385Recruiting
90-day trial of a probiotic for stress and sleep
This study tests whether a daily probiotic capsule called Neuralli Mood can help adults who feel stressed, have trouble sleeping, or experience low mood. It lasts 90 days and involves taking two capsules each day and filling out online surveys.
New York, New YorkAges 18 years+ - NCT04817072Recruiting
Studying mood changes in inflammatory arthritis patients on biologics
This study looks at how mood disorders (like depression or anxiety) affect people with chronic inflammatory joint diseases when they use biologic medicines. It may help doctors understand which patients are at higher mood-risk and how to monitor them.
BesançonAges 18–80 - NCT06408012Recruiting
Master platform for mood disorder trials
This trial creates a flexible platform to test new treatments for mood disorders like bipolar disorder and depression. It also includes healthy volunteers as a comparison group.
Calgary, AlbertaAges 16 years+ - NCT05672615Recruiting
Mood changes during bladder cancer treatment with BCG
This study looks at how bladder cancer treatment with BCG may affect mood and emotional well-being. It may help doctors understand which patients experience mood changes during care.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05797428Recruiting
Talk-based therapy to help teens cope with mood problems
This trial tests “logotherapy,” a type of counseling that helps people find meaning and purpose to cope with sadness or mood swings. It may help adolescents with mild to moderate-to-severe depression feel better and participate in structured therapy.
Kaohsiung City, Niaosong DistrictAges 15–24 - NCT05832489RecruitingPhase 3
EEG-MRI test of methylphenidate in adult attention symptoms
This Phase 3 study tests how methylphenidate affects brain signals and attention in adults with ADHD, and in adults with mood-related attention problems. It also includes healthy volunteers to compare brain responses during brain scanning.
StrasbourgAges 18–60 - NCT06358898Recruiting
Digital sleep and mood program for teens with depression
This trial tests a digital program that uses a smartphone app to help teens with both insomnia and depression. It combines a mood tracker with cognitive behavioral therapy for insomnia (CBT-I) to improve sleep and mood.
Shatin, New TerritoriesAges 12–18 - NCT06532500Recruiting
CBT therapy for teen mood and anxiety
This study tests whether cognitive behavioural therapy (CBT) — a talk therapy that helps you change unhelpful thoughts and behaviors — can improve mood and anxiety in teens. If you're between 14 and 19 and have a mood or anxiety disorder, this therapy might be a good fit.
Toronto, OntarioAges 14–19 - NCT06949813Recruiting
Preventing mood symptoms after C-section
This study tests a program to help prevent depression, anxiety, or trauma symptoms in people who have a cesarean delivery. It is for pregnant people who are in the hospital for at least 3 days before their C-section due to a high-risk pregnancy.
Aurora, ColoradoAges Any age - NCT07033923Recruiting
Brain study of mood changes in depression and bipolar disorder
This study uses a mobile app and brain scans to understand day-to-day mood changes in people with depression or bipolar disorder. It may help doctors learn how to better predict and treat these conditions.
Paris, ParisAges 18 years+ - NCT07073521Recruiting
Cognitive therapy for adjusting to vision loss
This study tests new ways to help people adjust to vision loss using thinking and coping strategies. If you are an adult with vision loss and willing to share feedback, this may be a good fit.
Chicago, IllinoisAges 18 years+ - NCT07211750Recruiting
Integrated care for older adults with depression and multiple health conditions
This trial tests a new integrated care program for older adults who have depression or bipolar disorder along with at least two other long-term physical health problems. The program aims to bring together your doctors and psychiatrist to improve your overall health.
LeuvenAges 65 years+ - NCT00024635Recruiting
Understanding Mood and Anxiety Disorders Study
This research study evaluates people with mood disorders (like depression or bipolar disorder), anxiety disorders, or people without these conditions to better understand how these conditions develop and affect the brain. Researchers will ask questions and may do other assessments to learn more.
Bethesda, MarylandAges 3–99 - NCT00397111Recruiting
MRI brain-scanning study of mood and anxiety in adults
This study uses brain MRI scans and mental tasks to better understand mood and anxiety problems. It may help researchers develop improved MRI methods for studying depression and healthy brain function.
Bethesda, MarylandAges 18–65 - NCT07523490Recruiting
Understanding Suicide Risk in Mood Disorders
This research study aims to identify factors that increase suicide risk in people with mood disorders (like depression or bipolar disorder). By completing questionnaires, you'll help doctors better understand and prevent suicide in patients with these conditions.
Tianjin, Tianjin MunicipalityAges 16–60 - NCT05384158Recruiting
Testing a computer game for low mood, low pleasure, or anxiety
This trial looks at how a computer-based task performs when someone is dealing with depression-like symptoms, such as low mood, low interest/pleasure, or anxiety that affects daily functioning. You might find it helpful if you fit their symptom and safety requirements and are comfortable with computer tasks and (for some parts) MRI scanning.
Roanoke, VirginiaAges 25–50 - NCT07188506Recruiting
Youth suicide risk: reducing risk factors in young people
This study looks at suicide risk factors in young people with mood disorders (like depression or bipolar disorder) and tests ways to reduce those risks. It may help if you are between 18 and 25, have a mood disorder, and can undergo an MRI.
Roma, RMAges 18–25
Hear when a new Mood trial opens
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Mood trials by city
Studies with a site in or near these metro areas.
Mood trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for mood?
- Yes. Clin2 currently lists 149 recruiting mood studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mood trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mood trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.