Clinical trials
Mood clinical trials
Below are recruiting mood clinical trials, each written for real people, not researchers. We’re tracking 148 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06020261Recruiting
Parent training for kids with irritability
This study tests if a parent management training program can help reduce irritability in children. You and your child will work together with a therapist to learn new ways to handle challenging behaviors.
Aurora, ColoradoAges 10–14 - NCT07220447RecruitingEarly Phase 1
L-Theanine for relaxation and mood in cancer survivors
This trial tests whether a natural supplement called L-theanine, found in green tea, can help cancer survivors feel more relaxed and improve their mood. You may qualify if you have finished cancer treatment, have been in surveillance for at least 6 months, and feel anxious.
Duarte, CaliforniaAges 18 years+ - NCT07008183Recruiting
Understanding mood changes during and after pregnancy
This study looks at women who are pregnant or just had a baby and are having their first psychiatric visit related to this pregnancy. It aims to understand how mood changes during this time might be linked to the thymus gland, which helps control the immune system.
Bordeaux, New AquitaineAges 18 years+ - NCT06639477Recruiting
Mood and sleep improvement study for older adults
This study tests whether adding a sleep treatment to regular depression medication can improve both mood and sleep in adults aged 55 and older. It may help if you have ongoing depression, sleep problems, and are already taking antidepressant medication.
Los Angeles, CaliforniaAges 55 years+ - NCT02821741Recruiting
Testing ear stimulation effects on pain and mood
This study tests whether stimulating the outside of your ear changes how you feel pain and how your mood/feelings are measured. It’s mainly testing a non-drug, ear-based approach and whether it affects pain signals.
Bethesda, MarylandAges 18–50 - NCT07052357Enrolling by invitation
Intern health study 2025
This study looks at how medical interns' health changes during their first year of training. You wear a wrist device and answer questions on your phone to help researchers understand stress, sleep, and well-being.
Ann Arbor, MichiganAges 18 years+ - NCT06072677Recruiting
Mood and testosterone in young teens
This study looks at how mood changes during puberty in young people aged 11 to 14. It tests whether using a mindfulness app (Healthy Minds) can help teens who have been through stress or feel down.
Chapel Hill, North CarolinaAges 11–14 - NCT06094088Recruiting
Yoga and heat study for mood improvement
This study tests whether practicing yoga in a heated room can improve mood in adults with moderate depression. You would attend yoga classes and complete surveys about your mood.
Cambridge, MassachusettsAges 18–65 - NCT07475845Recruiting
Yoga and therapy for teen depression
This study tests whether adding weekly yoga classes to a standard group therapy program helps teens feel better faster. It is for teenagers aged 12–18 who have mild to moderate depression and are safe to be physically active.
Boston, MassachusettsAges 12–18 - NCT07225088Recruiting
Mental health support for Latino cancer patients
This study tests a mental health intervention called DESCANSO to help Latino people with cancer who feel depressed, have trouble sleeping, or are very tired. You may join if you are a Latino adult with stage I-III solid tumor cancer, speak Spanish, and are currently or recently finished treatment.
Basking Ridge, New JerseyAges 18 years+ - NCT07740135Enrolling by invitation
Daily multivitamin effects on mood and well-being
This study tests whether taking a daily multivitamin (Centrum) for a period can improve mood and overall well-being. It uses a special EEG headset to measure brain activity, and participation involves filling out questionnaires and a facility visit.
Hamilton, OntarioAges 40–60 - NCT07719517Recruiting
Morning activities to boost mood after stroke
This study tests if doing simple, guided activities in the morning can help improve your mood after a stroke. If you often feel down and have trouble getting going in the morning, this program might offer a way to feel better.
Hong KongAges 18 years+ - NCT07180537Recruiting
Health course for joint and mood conditions
This study tests an online health course that helps improve diet and self-care to support cell health and wellbeing. It is for people with certain rheumatological conditions like rheumatoid arthritis, lupus, or psoriatic arthritis, who also have mood concerns.
Iowa City, IowaAges 18–100 - NCT03859297Recruiting
Testing how rumination changes in depressed teens
This study looks at what changes in “rumination” (repetitive worrying/thinking about negative thoughts) in teens with depression, and how those changes relate to recovery. It’s for ages 14–17 who have had major depression and meet specific screening and medical rules.
Columbus, OhioAges 14–17 - NCT03935646RecruitingPhase 2
Test of Adderall’s short-term effects in college students with ADHD
This study measures how stimulant medication (Adderall) affects college students with ADHD in the short term. It compares people with ADHD to students without ADHD to see what changes you may notice during the study.
Laramie, WyomingAges 18–29 - NCT04877977Recruiting
Long-Term Follow-Up for People With Mood Disorders
This study follows people with mood disorders over a long time to better understand how symptoms and functioning change. You may be able to join if you already agreed to take part in an earlier mood/anxiety study and you meet basic participation needs.
Bethesda, MarylandAges 18–99 - NCT04230421Recruiting
Smartphone treatment program for bipolar disorder
This trial is testing a smartphone-based treatment approach for people living with bipolar disorder. It may help by delivering support and care tools in a way that’s easier to use day to day.
CopenhagenAges 18 years+ - NCT04478305RecruitingPhase 1
Duavive trial for mood and anxiety in midlife women
This Phase 1 study tests Duavive’s effects on mood and anxiety symptoms in women going through perimenopause or early menopause. It may help clarify whether this treatment can reduce depression and/or anxiety symptoms in midlife.
Hamilton, OntarioAges 45–60 - NCT05197738Recruiting
Study using a sleep health app to improve sleep
This study tests a “sleep health” app (REFRESH) to see how it may help people track and improve sleep. You may be eligible if you’re an adult in the U.S. who can use the app on your own phone.
La Jolla, CaliforniaAges 18 years+ - NCT05217589Recruiting
Mood and emotions study on eating before exercise
This study looks at how different moods and emotions affect your body’s responses to eating a sports drink before you exercise. You may need to run for 30 minutes and watch/listen to video clips during the study.
Norfolk, VirginiaAges 18–55 - NCT05384158Recruiting
Testing a computer game for low mood, low pleasure, or anxiety
This trial looks at how a computer-based task performs when someone is dealing with depression-like symptoms, such as low mood, low interest/pleasure, or anxiety that affects daily functioning. You might find it helpful if you fit their symptom and safety requirements and are comfortable with computer tasks and (for some parts) MRI scanning.
Roanoke, VirginiaAges 25–50 - NCT05414708Recruiting
Art therapy for veterans with PTSD symptoms
This study tests whether art therapy can improve emotional well-being in military members who have significant PTSD symptoms. You would answer questionnaires and likely take part in art-making sessions as part of the treatment being studied.
Bethesda, MarylandAges 18–64 - NCT05427123Recruiting
Study for kids and teens with bipolar or cyclothymic disorder
This trial is testing treatments for children and teens (ages 9–19) who have been diagnosed with bipolar disorder or cyclothymic disorder. It also requires regular participation from a caregiver so the team can track symptoms and response over time.
Los Angeles, CaliforniaAges 9–19 - NCT05427708Recruiting
Breathing training to reduce anxiety symptoms
This study tests whether specific respiratory (breathing) training can reduce anxiety symptoms and fear responses. It may help people who have several kinds of anxiety or trauma-related anxiety, especially if they are not on anxiety medicines or only stable on them.
Austin, TexasAges 18 years+
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Common questions
- Are there clinical trials for mood?
- Yes. Clin2 currently lists 148 recruiting mood studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a mood trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a mood trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.